Polysaccharides from Laminaria japonica show hypoglycemic and hypolipidemic activities in mice with experimentally induced diabetes
Diabetes mellitus (DM) is a chronic metabolic disorder of the endocrine system. The rapid increase in the incidence of DM is a serious public health concern worldwide. The treatment of DM and its complications mainly involves the use of chemically or biochemically synthesized drugs, but these drugs...
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crsagepubl:10.1177/1535370214537751 2023-05-15T16:02:06+02:00 Polysaccharides from Laminaria japonica show hypoglycemic and hypolipidemic activities in mice with experimentally induced diabetes Jia, Xibei Yang, Juan Wang, Zhi Liu, Ruichan Xie, Rujuan 2014 http://dx.doi.org/10.1177/1535370214537751 http://journals.sagepub.com/doi/pdf/10.1177/1535370214537751 http://journals.sagepub.com/doi/full-xml/10.1177/1535370214537751 en eng SAGE Publications http://journals.sagepub.com/page/policies/text-and-data-mining-license Experimental Biology and Medicine volume 239, issue 12, page 1663-1670 ISSN 1535-3702 1535-3699 General Biochemistry, Genetics and Molecular Biology journal-article 2014 crsagepubl https://doi.org/10.1177/1535370214537751 2022-09-21T19:51:41Z Diabetes mellitus (DM) is a chronic metabolic disorder of the endocrine system. The rapid increase in the incidence of DM is a serious public health concern worldwide. The treatment of DM and its complications mainly involves the use of chemically or biochemically synthesized drugs, but these drugs also have adverse side effects. Therefore, there is an urgent need to search for drugs from natural sources that would cause fewer side effects. This study aimed to determine whether polysaccharides from Laminaria japonica (LJP) exert hypoglycemic and hypolipidemic effects in mice with alloxan-induced diabetes. To this end, diabetes was induced by alloxan injection (200 mg/kg body weight [bw], intraperitoneal [ip]). After induction of diabetes, diabetic mice were randomly divided into five groups: diabetic control (DC) group, glibenclamide-treated (DG) group, low-dose LJP-treated (DLL) group, moderate-dose LJP-treated (DML) group, and high-dose LJP-treated (DHL) group, with normal mice used as the control group (NC group). After treatment for 28 days, body weight, fasting blood glucose (FBG), serum insulin, total cholesterol (TC), triglyceride (TG), high-density lipoprotein-cholesterol (HDL-C), and low-density lipoprotein-cholesterol (LDL-C) levels were measured. The results revealed that LJP administration prevented body-weight loss, decreased FBG levels, and increased serum insulin levels in diabetic mice. Furthermore, it decreased TC, TG, and LDL-C levels, and increased HDL-C levels in these mice. Thus, the results indicate that LJP possesses hypoglycemic and hypolipidemic activities and polysaccharides from LJP may hold promise for the development of a drug of natural origin for the treatment of DM. Article in Journal/Newspaper DML SAGE Publications (via Crossref) Experimental Biology and Medicine 239 12 1663 1670 |
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SAGE Publications (via Crossref) |
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English |
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General Biochemistry, Genetics and Molecular Biology |
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General Biochemistry, Genetics and Molecular Biology Jia, Xibei Yang, Juan Wang, Zhi Liu, Ruichan Xie, Rujuan Polysaccharides from Laminaria japonica show hypoglycemic and hypolipidemic activities in mice with experimentally induced diabetes |
topic_facet |
General Biochemistry, Genetics and Molecular Biology |
description |
Diabetes mellitus (DM) is a chronic metabolic disorder of the endocrine system. The rapid increase in the incidence of DM is a serious public health concern worldwide. The treatment of DM and its complications mainly involves the use of chemically or biochemically synthesized drugs, but these drugs also have adverse side effects. Therefore, there is an urgent need to search for drugs from natural sources that would cause fewer side effects. This study aimed to determine whether polysaccharides from Laminaria japonica (LJP) exert hypoglycemic and hypolipidemic effects in mice with alloxan-induced diabetes. To this end, diabetes was induced by alloxan injection (200 mg/kg body weight [bw], intraperitoneal [ip]). After induction of diabetes, diabetic mice were randomly divided into five groups: diabetic control (DC) group, glibenclamide-treated (DG) group, low-dose LJP-treated (DLL) group, moderate-dose LJP-treated (DML) group, and high-dose LJP-treated (DHL) group, with normal mice used as the control group (NC group). After treatment for 28 days, body weight, fasting blood glucose (FBG), serum insulin, total cholesterol (TC), triglyceride (TG), high-density lipoprotein-cholesterol (HDL-C), and low-density lipoprotein-cholesterol (LDL-C) levels were measured. The results revealed that LJP administration prevented body-weight loss, decreased FBG levels, and increased serum insulin levels in diabetic mice. Furthermore, it decreased TC, TG, and LDL-C levels, and increased HDL-C levels in these mice. Thus, the results indicate that LJP possesses hypoglycemic and hypolipidemic activities and polysaccharides from LJP may hold promise for the development of a drug of natural origin for the treatment of DM. |
format |
Article in Journal/Newspaper |
author |
Jia, Xibei Yang, Juan Wang, Zhi Liu, Ruichan Xie, Rujuan |
author_facet |
Jia, Xibei Yang, Juan Wang, Zhi Liu, Ruichan Xie, Rujuan |
author_sort |
Jia, Xibei |
title |
Polysaccharides from Laminaria japonica show hypoglycemic and hypolipidemic activities in mice with experimentally induced diabetes |
title_short |
Polysaccharides from Laminaria japonica show hypoglycemic and hypolipidemic activities in mice with experimentally induced diabetes |
title_full |
Polysaccharides from Laminaria japonica show hypoglycemic and hypolipidemic activities in mice with experimentally induced diabetes |
title_fullStr |
Polysaccharides from Laminaria japonica show hypoglycemic and hypolipidemic activities in mice with experimentally induced diabetes |
title_full_unstemmed |
Polysaccharides from Laminaria japonica show hypoglycemic and hypolipidemic activities in mice with experimentally induced diabetes |
title_sort |
polysaccharides from laminaria japonica show hypoglycemic and hypolipidemic activities in mice with experimentally induced diabetes |
publisher |
SAGE Publications |
publishDate |
2014 |
url |
http://dx.doi.org/10.1177/1535370214537751 http://journals.sagepub.com/doi/pdf/10.1177/1535370214537751 http://journals.sagepub.com/doi/full-xml/10.1177/1535370214537751 |
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DML |
genre_facet |
DML |
op_source |
Experimental Biology and Medicine volume 239, issue 12, page 1663-1670 ISSN 1535-3702 1535-3699 |
op_rights |
http://journals.sagepub.com/page/policies/text-and-data-mining-license |
op_doi |
https://doi.org/10.1177/1535370214537751 |
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Experimental Biology and Medicine |
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239 |
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12 |
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1663 |
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1670 |
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1766397717589786624 |