Incidence of and risk factors for type-2 diabetes in a general population: The Tromsø Study
Aims: To determine the gender-specific incidence and risk factors of type-2 diabetes mellitus (T2DM) in a general population. Methods: The study is based on 12,431 men and 13,737 women aged 25-98 years, attending the Tromsø Study in 1994 and followed through 2005, who did not have diabetes when ente...
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crsagepubl:10.1177/1403494810380299 2024-05-19T07:49:32+00:00 Incidence of and risk factors for type-2 diabetes in a general population: The Tromsø Study Joseph, Josepha Svartberg, Johan Njølstad, Inger Schirmer, Henrik 2010 http://dx.doi.org/10.1177/1403494810380299 http://journals.sagepub.com/doi/pdf/10.1177/1403494810380299 en eng SAGE Publications http://journals.sagepub.com/page/policies/text-and-data-mining-license Scandinavian Journal of Public Health volume 38, issue 7, page 768-775 ISSN 1403-4948 1651-1905 journal-article 2010 crsagepubl https://doi.org/10.1177/1403494810380299 2024-05-02T09:40:22Z Aims: To determine the gender-specific incidence and risk factors of type-2 diabetes mellitus (T2DM) in a general population. Methods: The study is based on 12,431 men and 13,737 women aged 25-98 years, attending the Tromsø Study in 1994 and followed through 2005, who did not have diabetes when entering the study. Sex-specific hazard ratios were estimated from Cox proportional hazard models. Results: A total of 522 cases of T2DM were registered, 308 among men and 214 among women. The age-standardised incidence rate was higher in men than in women, 2.6 (95% CI 2.32—2.90) and 1.6 (95% CI 1.40—1.83) per 1000 person-years, respectively. In multivariate survival analysis, age, body mass index (BMI), triglycerides, high-density lipoprotein (HDL) cholesterol, hypertension, family history of diabetes, low education and smoking were independent predictors of T2DM in both genders (p>0.05). Total cholesterol and lack of leisure-time physical activity were independent predictors in men only. We found an interaction between HDL cholesterol and triglyceride levels (p>0.001) and between triglyceride levels and a positive family history of diabetes (p = 0.04). These interactions were independent of BMI. A positive family history combined with triglycerides in the highest tertile and BMI >25 kg/m 2 conveyed a 10-year risk of T2DM of 10% (95% CI 8—12%) vs. 0.2% (95% CI 0.08—0.31%) for the lowest risk group. Conclusions: A family history of diabetes, elevated BMI, and high triglyceride levels identifies independent of cardiovascular risk factors, a group with especially high risk of T2DM. Article in Journal/Newspaper Tromsø SAGE Publications Scandinavian Journal of Public Health 38 7 768 775 |
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Aims: To determine the gender-specific incidence and risk factors of type-2 diabetes mellitus (T2DM) in a general population. Methods: The study is based on 12,431 men and 13,737 women aged 25-98 years, attending the Tromsø Study in 1994 and followed through 2005, who did not have diabetes when entering the study. Sex-specific hazard ratios were estimated from Cox proportional hazard models. Results: A total of 522 cases of T2DM were registered, 308 among men and 214 among women. The age-standardised incidence rate was higher in men than in women, 2.6 (95% CI 2.32—2.90) and 1.6 (95% CI 1.40—1.83) per 1000 person-years, respectively. In multivariate survival analysis, age, body mass index (BMI), triglycerides, high-density lipoprotein (HDL) cholesterol, hypertension, family history of diabetes, low education and smoking were independent predictors of T2DM in both genders (p>0.05). Total cholesterol and lack of leisure-time physical activity were independent predictors in men only. We found an interaction between HDL cholesterol and triglyceride levels (p>0.001) and between triglyceride levels and a positive family history of diabetes (p = 0.04). These interactions were independent of BMI. A positive family history combined with triglycerides in the highest tertile and BMI >25 kg/m 2 conveyed a 10-year risk of T2DM of 10% (95% CI 8—12%) vs. 0.2% (95% CI 0.08—0.31%) for the lowest risk group. Conclusions: A family history of diabetes, elevated BMI, and high triglyceride levels identifies independent of cardiovascular risk factors, a group with especially high risk of T2DM. |
format |
Article in Journal/Newspaper |
author |
Joseph, Josepha Svartberg, Johan Njølstad, Inger Schirmer, Henrik |
spellingShingle |
Joseph, Josepha Svartberg, Johan Njølstad, Inger Schirmer, Henrik Incidence of and risk factors for type-2 diabetes in a general population: The Tromsø Study |
author_facet |
Joseph, Josepha Svartberg, Johan Njølstad, Inger Schirmer, Henrik |
author_sort |
Joseph, Josepha |
title |
Incidence of and risk factors for type-2 diabetes in a general population: The Tromsø Study |
title_short |
Incidence of and risk factors for type-2 diabetes in a general population: The Tromsø Study |
title_full |
Incidence of and risk factors for type-2 diabetes in a general population: The Tromsø Study |
title_fullStr |
Incidence of and risk factors for type-2 diabetes in a general population: The Tromsø Study |
title_full_unstemmed |
Incidence of and risk factors for type-2 diabetes in a general population: The Tromsø Study |
title_sort |
incidence of and risk factors for type-2 diabetes in a general population: the tromsø study |
publisher |
SAGE Publications |
publishDate |
2010 |
url |
http://dx.doi.org/10.1177/1403494810380299 http://journals.sagepub.com/doi/pdf/10.1177/1403494810380299 |
genre |
Tromsø |
genre_facet |
Tromsø |
op_source |
Scandinavian Journal of Public Health volume 38, issue 7, page 768-775 ISSN 1403-4948 1651-1905 |
op_rights |
http://journals.sagepub.com/page/policies/text-and-data-mining-license |
op_doi |
https://doi.org/10.1177/1403494810380299 |
container_title |
Scandinavian Journal of Public Health |
container_volume |
38 |
container_issue |
7 |
container_start_page |
768 |
op_container_end_page |
775 |
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1799468043820072960 |