Predictors of the Virological Response to a Change in the Antiretroviral Treatment Regimen in HIV-1-Infected Patients Enrolled in a Randomized Trial Comparing Genotyping, Phenotyping and Standard of Care (Narval Trial, Anrs 088)
Objective To identify predictors of the virological response to antiretroviral therapy in patients in whom initial therapy has failed. Methods The Narval trial was designed to compare phenotyping, genotyping and standard of care for the choice of antiretroviral therapy in patients in whom a protease...
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crsagepubl:10.1177/135965350300800510 2024-03-24T09:05:50+00:00 Predictors of the Virological Response to a Change in the Antiretroviral Treatment Regimen in HIV-1-Infected Patients Enrolled in a Randomized Trial Comparing Genotyping, Phenotyping and Standard of Care (Narval Trial, Anrs 088) Vray, Muriel Meynard, Jean-Luc Dalban, Cécile Morand-Joubert, Laurence Clavel, François Brun-Vézinet, Françoise Peytavin, Gilles Costagliola, Dominique Girard, Pierre-Marie 2002 http://dx.doi.org/10.1177/135965350300800510 http://journals.sagepub.com/doi/pdf/10.1177/135965350300800510 en eng SAGE Publications http://journals.sagepub.com/page/policies/text-and-data-mining-license Antiviral Therapy volume 8, issue 5, page 427-434 ISSN 1359-6535 2040-2058 Infectious Diseases Pharmacology (medical) Pharmacology journal-article 2002 crsagepubl https://doi.org/10.1177/135965350300800510 2024-02-26T16:05:28Z Objective To identify predictors of the virological response to antiretroviral therapy in patients in whom initial therapy has failed. Methods The Narval trial was designed to compare phenotyping, genotyping and standard of care for the choice of antiretroviral therapy in patients in whom a protease inhibitor (PI)-containing regimen had failed. Virological success was defined as viral load below 200 copies/ml at week 12. Baseline variables including demographic, clinical and biological characteristics, HIV reverse transcriptase and protease mutations, the randomization arm, the drugs prescribed, as well as adherence to treatment and plasma concentrations of PIs and non-nucleoside reverse transcriptase inhibitors (NNRTIs) at week 12 were tested in the model. Variables that were significantly associated with virological success in univariate analysis were included in a logistic regression model. Results Five-hundred-and-forty-one patients were randomized. Virological success at week 12 was obtained in 200 patients. In multivariate analysis, the following factors were significantly associated with virological success: prescription of efavirenz to NNRTI-naive patients (OR=4.37; 95% CI: 2.76–6.90), randomization to the genotyping arm (OR=2.13, 1.20–3.79), prescription of lamivudine (OR=1.69, 1.01–2.83) and prescription of abacavir to abacavir-naive patients (OR=1.66, 1.02–2.72). Factors significantly associated with virological failure were prescription of nelfinavir (OR=0.30, 0.13–0.68), a high baseline viral load (OR=0.37, 0.28–0.50), the presence of at least five PI mutations (OR=0.42, 0.26–0.66), the presence of at least three thymidine analogue mutations (OR=0.61, 0.39–0.97) and at least 30 months of prior PI exposure (OR=0.64, 0.41–0.99). Conclusions These results confirm that among heavily pretreated patients, prescription of efavirenz to NNRTI-naive patients is associated with a good virological response, while a high baseline viral load, a large number of PI mutations and nelfinavir prescription at baseline ... Article in Journal/Newspaper narval narval SAGE Publications Antiviral Therapy 8 5 427 434 |
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Infectious Diseases Pharmacology (medical) Pharmacology |
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Infectious Diseases Pharmacology (medical) Pharmacology Vray, Muriel Meynard, Jean-Luc Dalban, Cécile Morand-Joubert, Laurence Clavel, François Brun-Vézinet, Françoise Peytavin, Gilles Costagliola, Dominique Girard, Pierre-Marie Predictors of the Virological Response to a Change in the Antiretroviral Treatment Regimen in HIV-1-Infected Patients Enrolled in a Randomized Trial Comparing Genotyping, Phenotyping and Standard of Care (Narval Trial, Anrs 088) |
topic_facet |
Infectious Diseases Pharmacology (medical) Pharmacology |
description |
Objective To identify predictors of the virological response to antiretroviral therapy in patients in whom initial therapy has failed. Methods The Narval trial was designed to compare phenotyping, genotyping and standard of care for the choice of antiretroviral therapy in patients in whom a protease inhibitor (PI)-containing regimen had failed. Virological success was defined as viral load below 200 copies/ml at week 12. Baseline variables including demographic, clinical and biological characteristics, HIV reverse transcriptase and protease mutations, the randomization arm, the drugs prescribed, as well as adherence to treatment and plasma concentrations of PIs and non-nucleoside reverse transcriptase inhibitors (NNRTIs) at week 12 were tested in the model. Variables that were significantly associated with virological success in univariate analysis were included in a logistic regression model. Results Five-hundred-and-forty-one patients were randomized. Virological success at week 12 was obtained in 200 patients. In multivariate analysis, the following factors were significantly associated with virological success: prescription of efavirenz to NNRTI-naive patients (OR=4.37; 95% CI: 2.76–6.90), randomization to the genotyping arm (OR=2.13, 1.20–3.79), prescription of lamivudine (OR=1.69, 1.01–2.83) and prescription of abacavir to abacavir-naive patients (OR=1.66, 1.02–2.72). Factors significantly associated with virological failure were prescription of nelfinavir (OR=0.30, 0.13–0.68), a high baseline viral load (OR=0.37, 0.28–0.50), the presence of at least five PI mutations (OR=0.42, 0.26–0.66), the presence of at least three thymidine analogue mutations (OR=0.61, 0.39–0.97) and at least 30 months of prior PI exposure (OR=0.64, 0.41–0.99). Conclusions These results confirm that among heavily pretreated patients, prescription of efavirenz to NNRTI-naive patients is associated with a good virological response, while a high baseline viral load, a large number of PI mutations and nelfinavir prescription at baseline ... |
format |
Article in Journal/Newspaper |
author |
Vray, Muriel Meynard, Jean-Luc Dalban, Cécile Morand-Joubert, Laurence Clavel, François Brun-Vézinet, Françoise Peytavin, Gilles Costagliola, Dominique Girard, Pierre-Marie |
author_facet |
Vray, Muriel Meynard, Jean-Luc Dalban, Cécile Morand-Joubert, Laurence Clavel, François Brun-Vézinet, Françoise Peytavin, Gilles Costagliola, Dominique Girard, Pierre-Marie |
author_sort |
Vray, Muriel |
title |
Predictors of the Virological Response to a Change in the Antiretroviral Treatment Regimen in HIV-1-Infected Patients Enrolled in a Randomized Trial Comparing Genotyping, Phenotyping and Standard of Care (Narval Trial, Anrs 088) |
title_short |
Predictors of the Virological Response to a Change in the Antiretroviral Treatment Regimen in HIV-1-Infected Patients Enrolled in a Randomized Trial Comparing Genotyping, Phenotyping and Standard of Care (Narval Trial, Anrs 088) |
title_full |
Predictors of the Virological Response to a Change in the Antiretroviral Treatment Regimen in HIV-1-Infected Patients Enrolled in a Randomized Trial Comparing Genotyping, Phenotyping and Standard of Care (Narval Trial, Anrs 088) |
title_fullStr |
Predictors of the Virological Response to a Change in the Antiretroviral Treatment Regimen in HIV-1-Infected Patients Enrolled in a Randomized Trial Comparing Genotyping, Phenotyping and Standard of Care (Narval Trial, Anrs 088) |
title_full_unstemmed |
Predictors of the Virological Response to a Change in the Antiretroviral Treatment Regimen in HIV-1-Infected Patients Enrolled in a Randomized Trial Comparing Genotyping, Phenotyping and Standard of Care (Narval Trial, Anrs 088) |
title_sort |
predictors of the virological response to a change in the antiretroviral treatment regimen in hiv-1-infected patients enrolled in a randomized trial comparing genotyping, phenotyping and standard of care (narval trial, anrs 088) |
publisher |
SAGE Publications |
publishDate |
2002 |
url |
http://dx.doi.org/10.1177/135965350300800510 http://journals.sagepub.com/doi/pdf/10.1177/135965350300800510 |
genre |
narval narval |
genre_facet |
narval narval |
op_source |
Antiviral Therapy volume 8, issue 5, page 427-434 ISSN 1359-6535 2040-2058 |
op_rights |
http://journals.sagepub.com/page/policies/text-and-data-mining-license |
op_doi |
https://doi.org/10.1177/135965350300800510 |
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Antiviral Therapy |
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8 |
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434 |
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1794407708964683776 |