Dual Analysis of Virus-Host Interactions: The Case of Ostreid herpesvirus 1 and the Cupped Oyster Crassostrea gigas
Dual analyses of the interactions between Ostreid herpesvirus 1 (OsHV-1) and the bivalve Crassostrea gigas during infection can unveil events critical to the onset and progression of this viral disease and can provide novel strategies for mitigating and preventing oyster mortality. Among the current...
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crsagepubl:10.1177/1176934319831305 2024-10-13T14:06:44+00:00 Dual Analysis of Virus-Host Interactions: The Case of Ostreid herpesvirus 1 and the Cupped Oyster Crassostrea gigas Rosani, Umberto Young, Tim Bai, Chang-Ming Alfaro, Andrea C. Venier, Paola horizon 2020 università degli studi di padova 2019 http://dx.doi.org/10.1177/1176934319831305 https://journals.sagepub.com/doi/pdf/10.1177/1176934319831305 https://journals.sagepub.com/doi/full-xml/10.1177/1176934319831305 en eng SAGE Publications https://journals.sagepub.com/page/policies/text-and-data-mining-license Evolutionary Bioinformatics volume 15 ISSN 1176-9343 1176-9343 journal-article 2019 crsagepubl https://doi.org/10.1177/1176934319831305 2024-10-01T04:08:09Z Dual analyses of the interactions between Ostreid herpesvirus 1 (OsHV-1) and the bivalve Crassostrea gigas during infection can unveil events critical to the onset and progression of this viral disease and can provide novel strategies for mitigating and preventing oyster mortality. Among the currently used “omics” technologies, dual transcriptomics (dual RNA-seq) coupled with the analysis of viral DNA in the host tissues has greatly advanced the knowledge of genes and pathways mostly contributing to host defense responses, expression profiles of annotated and unknown OsHV-1 open reading frames (ORFs), and viral genome variability. In addition to dual RNA-seq, proteomics and metabolomics analyses have the potential to add complementary information, needed to understand how a malacoherpesvirus can redirect and exploit the vital processes of its host. This review explores our current knowledge of “omics” technologies in the study of host-pathogen interactions and highlights relevant applications of these fields of expertise to the complex case of C gigas infections by OsHV-1, which currently threaten the mollusk production sector worldwide. Article in Journal/Newspaper Crassostrea gigas SAGE Publications Evolutionary Bioinformatics 15 117693431983130 |
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Open Polar |
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SAGE Publications |
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crsagepubl |
language |
English |
description |
Dual analyses of the interactions between Ostreid herpesvirus 1 (OsHV-1) and the bivalve Crassostrea gigas during infection can unveil events critical to the onset and progression of this viral disease and can provide novel strategies for mitigating and preventing oyster mortality. Among the currently used “omics” technologies, dual transcriptomics (dual RNA-seq) coupled with the analysis of viral DNA in the host tissues has greatly advanced the knowledge of genes and pathways mostly contributing to host defense responses, expression profiles of annotated and unknown OsHV-1 open reading frames (ORFs), and viral genome variability. In addition to dual RNA-seq, proteomics and metabolomics analyses have the potential to add complementary information, needed to understand how a malacoherpesvirus can redirect and exploit the vital processes of its host. This review explores our current knowledge of “omics” technologies in the study of host-pathogen interactions and highlights relevant applications of these fields of expertise to the complex case of C gigas infections by OsHV-1, which currently threaten the mollusk production sector worldwide. |
author2 |
horizon 2020 università degli studi di padova |
format |
Article in Journal/Newspaper |
author |
Rosani, Umberto Young, Tim Bai, Chang-Ming Alfaro, Andrea C. Venier, Paola |
spellingShingle |
Rosani, Umberto Young, Tim Bai, Chang-Ming Alfaro, Andrea C. Venier, Paola Dual Analysis of Virus-Host Interactions: The Case of Ostreid herpesvirus 1 and the Cupped Oyster Crassostrea gigas |
author_facet |
Rosani, Umberto Young, Tim Bai, Chang-Ming Alfaro, Andrea C. Venier, Paola |
author_sort |
Rosani, Umberto |
title |
Dual Analysis of Virus-Host Interactions: The Case of Ostreid herpesvirus 1 and the Cupped Oyster Crassostrea gigas |
title_short |
Dual Analysis of Virus-Host Interactions: The Case of Ostreid herpesvirus 1 and the Cupped Oyster Crassostrea gigas |
title_full |
Dual Analysis of Virus-Host Interactions: The Case of Ostreid herpesvirus 1 and the Cupped Oyster Crassostrea gigas |
title_fullStr |
Dual Analysis of Virus-Host Interactions: The Case of Ostreid herpesvirus 1 and the Cupped Oyster Crassostrea gigas |
title_full_unstemmed |
Dual Analysis of Virus-Host Interactions: The Case of Ostreid herpesvirus 1 and the Cupped Oyster Crassostrea gigas |
title_sort |
dual analysis of virus-host interactions: the case of ostreid herpesvirus 1 and the cupped oyster crassostrea gigas |
publisher |
SAGE Publications |
publishDate |
2019 |
url |
http://dx.doi.org/10.1177/1176934319831305 https://journals.sagepub.com/doi/pdf/10.1177/1176934319831305 https://journals.sagepub.com/doi/full-xml/10.1177/1176934319831305 |
genre |
Crassostrea gigas |
genre_facet |
Crassostrea gigas |
op_source |
Evolutionary Bioinformatics volume 15 ISSN 1176-9343 1176-9343 |
op_rights |
https://journals.sagepub.com/page/policies/text-and-data-mining-license |
op_doi |
https://doi.org/10.1177/1176934319831305 |
container_title |
Evolutionary Bioinformatics |
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15 |
container_start_page |
117693431983130 |
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1812812958189748224 |