Comparison of cytology and human papillomavirus-based primary testing in cervical screening programs in the Nordic countries
Objective To compare primary test positivity in cytology and human papillomavirus-based screening between different Nordic cervical cancer screening programs using harmonized register data. Methods This study utilized individual-level data available in national databases in Finland, Iceland, Norway,...
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crsagepubl:10.1177/0969141321992404 2024-04-28T08:25:46+00:00 Comparison of cytology and human papillomavirus-based primary testing in cervical screening programs in the Nordic countries Partanen, Veli-Matti Dillner, Joakim Tropé, Ameli Ágústsson, Ágúst Ingi Pankakoski, Maiju Heinävaara, Sirpa Sarkeala, Tytti Wang, Jiangrong Skare, Gry Baadstrand Anttila, Ahti Lönnberg, Stefan Nordic Cancer Union 2021 http://dx.doi.org/10.1177/0969141321992404 http://journals.sagepub.com/doi/pdf/10.1177/0969141321992404 http://journals.sagepub.com/doi/full-xml/10.1177/0969141321992404 en eng SAGE Publications http://journals.sagepub.com/page/policies/text-and-data-mining-license Journal of Medical Screening volume 28, issue 4, page 464-471 ISSN 0969-1413 1475-5793 Public Health, Environmental and Occupational Health Health Policy journal-article 2021 crsagepubl https://doi.org/10.1177/0969141321992404 2024-04-09T08:02:03Z Objective To compare primary test positivity in cytology and human papillomavirus-based screening between different Nordic cervical cancer screening programs using harmonized register data. Methods This study utilized individual-level data available in national databases in Finland, Iceland, Norway, and Sweden. Cervical test data from each country were converted to standard format and aggregated by calculating the number of test episodes for every test result for each calendar year and one-year age group and test method. Test positivity was estimated as the proportion of positive test results of all primary test episodes with a valid test result for “any positive” and “clearly positive” results. Results The age-adjusted rate ratio for any positive test results in primary human papillomavirus-based screening compared to cytology was 1.66 (95% CI 1.64–1.68). The age-adjusted rate ratio for clearly positive test results was 1.02 (95% CI 1.00–1.05). A decreasing rate ratio by age was seen in both any positive and clearly positive test results. Test positivity increased over time in Iceland, Norway, and Sweden but slightly decreased in Finland. Conclusions The probability of any positive test result was higher in human papillomavirus testing than in primary cytology, even though the cross-sectional detection of a clearly positive test result was the same. Human papillomavirus testing can still lead to an improved longitudinal sensitivity through a larger number of follow-up tests and the opportunity to identify women with a persistent human papillomavirus infection. Further research on histologically verified precancerous lesions is needed in primary as well as repeat testing. Article in Journal/Newspaper Iceland SAGE Publications Journal of Medical Screening 096914132199240 |
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English |
topic |
Public Health, Environmental and Occupational Health Health Policy |
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Public Health, Environmental and Occupational Health Health Policy Partanen, Veli-Matti Dillner, Joakim Tropé, Ameli Ágústsson, Ágúst Ingi Pankakoski, Maiju Heinävaara, Sirpa Sarkeala, Tytti Wang, Jiangrong Skare, Gry Baadstrand Anttila, Ahti Lönnberg, Stefan Comparison of cytology and human papillomavirus-based primary testing in cervical screening programs in the Nordic countries |
topic_facet |
Public Health, Environmental and Occupational Health Health Policy |
description |
Objective To compare primary test positivity in cytology and human papillomavirus-based screening between different Nordic cervical cancer screening programs using harmonized register data. Methods This study utilized individual-level data available in national databases in Finland, Iceland, Norway, and Sweden. Cervical test data from each country were converted to standard format and aggregated by calculating the number of test episodes for every test result for each calendar year and one-year age group and test method. Test positivity was estimated as the proportion of positive test results of all primary test episodes with a valid test result for “any positive” and “clearly positive” results. Results The age-adjusted rate ratio for any positive test results in primary human papillomavirus-based screening compared to cytology was 1.66 (95% CI 1.64–1.68). The age-adjusted rate ratio for clearly positive test results was 1.02 (95% CI 1.00–1.05). A decreasing rate ratio by age was seen in both any positive and clearly positive test results. Test positivity increased over time in Iceland, Norway, and Sweden but slightly decreased in Finland. Conclusions The probability of any positive test result was higher in human papillomavirus testing than in primary cytology, even though the cross-sectional detection of a clearly positive test result was the same. Human papillomavirus testing can still lead to an improved longitudinal sensitivity through a larger number of follow-up tests and the opportunity to identify women with a persistent human papillomavirus infection. Further research on histologically verified precancerous lesions is needed in primary as well as repeat testing. |
author2 |
Nordic Cancer Union |
format |
Article in Journal/Newspaper |
author |
Partanen, Veli-Matti Dillner, Joakim Tropé, Ameli Ágústsson, Ágúst Ingi Pankakoski, Maiju Heinävaara, Sirpa Sarkeala, Tytti Wang, Jiangrong Skare, Gry Baadstrand Anttila, Ahti Lönnberg, Stefan |
author_facet |
Partanen, Veli-Matti Dillner, Joakim Tropé, Ameli Ágústsson, Ágúst Ingi Pankakoski, Maiju Heinävaara, Sirpa Sarkeala, Tytti Wang, Jiangrong Skare, Gry Baadstrand Anttila, Ahti Lönnberg, Stefan |
author_sort |
Partanen, Veli-Matti |
title |
Comparison of cytology and human papillomavirus-based primary testing in cervical screening programs in the Nordic countries |
title_short |
Comparison of cytology and human papillomavirus-based primary testing in cervical screening programs in the Nordic countries |
title_full |
Comparison of cytology and human papillomavirus-based primary testing in cervical screening programs in the Nordic countries |
title_fullStr |
Comparison of cytology and human papillomavirus-based primary testing in cervical screening programs in the Nordic countries |
title_full_unstemmed |
Comparison of cytology and human papillomavirus-based primary testing in cervical screening programs in the Nordic countries |
title_sort |
comparison of cytology and human papillomavirus-based primary testing in cervical screening programs in the nordic countries |
publisher |
SAGE Publications |
publishDate |
2021 |
url |
http://dx.doi.org/10.1177/0969141321992404 http://journals.sagepub.com/doi/pdf/10.1177/0969141321992404 http://journals.sagepub.com/doi/full-xml/10.1177/0969141321992404 |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
Journal of Medical Screening volume 28, issue 4, page 464-471 ISSN 0969-1413 1475-5793 |
op_rights |
http://journals.sagepub.com/page/policies/text-and-data-mining-license |
op_doi |
https://doi.org/10.1177/0969141321992404 |
container_title |
Journal of Medical Screening |
container_start_page |
096914132199240 |
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