Titanium scaffold loaded with strontium and copper double-doped hydroxyapatite can inhibit bacterial growth and enhance osteogenesis
Co-doping of multiple ions can effectively adjust the biological properties of hydroxyapatite (HA) for various biomedical applications. In this study, we prepared Sr 2+ and Cu 2+ double-doped hollow HA and characterized them by SEM, EDS, XRD, FTIR, and other methods. We found that Sr 2+ and Cu 2+ we...
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crsagepubl:10.1177/08853282221080525 2024-09-15T18:01:38+00:00 Titanium scaffold loaded with strontium and copper double-doped hydroxyapatite can inhibit bacterial growth and enhance osteogenesis Li, Shihong He, Yang Li, Jian Sheng, Jun Long, Shiwei Li, Zhiqiang Jiang, Bobo Fu, Hong Weng, Jie Wu, Juan Zheng, Wei On-site treatment and infection control strategies for blast injuries of extremities 2022 http://dx.doi.org/10.1177/08853282221080525 http://journals.sagepub.com/doi/pdf/10.1177/08853282221080525 http://journals.sagepub.com/doi/full-xml/10.1177/08853282221080525 en eng SAGE Publications http://journals.sagepub.com/page/policies/text-and-data-mining-license Journal of Biomaterials Applications volume 37, issue 2, page 195-203 ISSN 0885-3282 1530-8022 journal-article 2022 crsagepubl https://doi.org/10.1177/08853282221080525 2024-07-22T04:32:27Z Co-doping of multiple ions can effectively adjust the biological properties of hydroxyapatite (HA) for various biomedical applications. In this study, we prepared Sr 2+ and Cu 2+ double-doped hollow HA and characterized them by SEM, EDS, XRD, FTIR, and other methods. We found that Sr 2+ and Cu 2+ were uniformly distributed in the hollow carbonic acid HA microspheres. As the proportion of metal elements increases, the microspherical appearance and crystallinity properties also change. In addition, we also prepared porous titanium scaffolds through 3D printing technology and constructed composite scaffolds of porous titanium scaffolds, Sr 2+ and Cu 2+ double-doped HA, and gelatin. In vitro cell experiments and bacterial experiments, the composite scaffolds, especially the 10%Cu-10%Sr- HA/Gel/Ti group scaffolds, have good biocompatibility and integration with bone tissues, promoting the proliferation and differentiation of BMSCs while having excellent antibacterial properties. These composite scaffolds can simultaneously achieve bone defect filling, osteoblast differentiation, and antibacterial functions, owning broad clinical application prospects. Article in Journal/Newspaper Carbonic acid SAGE Publications Journal of Biomaterials Applications 37 2 195 203 |
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English |
description |
Co-doping of multiple ions can effectively adjust the biological properties of hydroxyapatite (HA) for various biomedical applications. In this study, we prepared Sr 2+ and Cu 2+ double-doped hollow HA and characterized them by SEM, EDS, XRD, FTIR, and other methods. We found that Sr 2+ and Cu 2+ were uniformly distributed in the hollow carbonic acid HA microspheres. As the proportion of metal elements increases, the microspherical appearance and crystallinity properties also change. In addition, we also prepared porous titanium scaffolds through 3D printing technology and constructed composite scaffolds of porous titanium scaffolds, Sr 2+ and Cu 2+ double-doped HA, and gelatin. In vitro cell experiments and bacterial experiments, the composite scaffolds, especially the 10%Cu-10%Sr- HA/Gel/Ti group scaffolds, have good biocompatibility and integration with bone tissues, promoting the proliferation and differentiation of BMSCs while having excellent antibacterial properties. These composite scaffolds can simultaneously achieve bone defect filling, osteoblast differentiation, and antibacterial functions, owning broad clinical application prospects. |
author2 |
On-site treatment and infection control strategies for blast injuries of extremities |
format |
Article in Journal/Newspaper |
author |
Li, Shihong He, Yang Li, Jian Sheng, Jun Long, Shiwei Li, Zhiqiang Jiang, Bobo Fu, Hong Weng, Jie Wu, Juan Zheng, Wei |
spellingShingle |
Li, Shihong He, Yang Li, Jian Sheng, Jun Long, Shiwei Li, Zhiqiang Jiang, Bobo Fu, Hong Weng, Jie Wu, Juan Zheng, Wei Titanium scaffold loaded with strontium and copper double-doped hydroxyapatite can inhibit bacterial growth and enhance osteogenesis |
author_facet |
Li, Shihong He, Yang Li, Jian Sheng, Jun Long, Shiwei Li, Zhiqiang Jiang, Bobo Fu, Hong Weng, Jie Wu, Juan Zheng, Wei |
author_sort |
Li, Shihong |
title |
Titanium scaffold loaded with strontium and copper double-doped hydroxyapatite can inhibit bacterial growth and enhance osteogenesis |
title_short |
Titanium scaffold loaded with strontium and copper double-doped hydroxyapatite can inhibit bacterial growth and enhance osteogenesis |
title_full |
Titanium scaffold loaded with strontium and copper double-doped hydroxyapatite can inhibit bacterial growth and enhance osteogenesis |
title_fullStr |
Titanium scaffold loaded with strontium and copper double-doped hydroxyapatite can inhibit bacterial growth and enhance osteogenesis |
title_full_unstemmed |
Titanium scaffold loaded with strontium and copper double-doped hydroxyapatite can inhibit bacterial growth and enhance osteogenesis |
title_sort |
titanium scaffold loaded with strontium and copper double-doped hydroxyapatite can inhibit bacterial growth and enhance osteogenesis |
publisher |
SAGE Publications |
publishDate |
2022 |
url |
http://dx.doi.org/10.1177/08853282221080525 http://journals.sagepub.com/doi/pdf/10.1177/08853282221080525 http://journals.sagepub.com/doi/full-xml/10.1177/08853282221080525 |
genre |
Carbonic acid |
genre_facet |
Carbonic acid |
op_source |
Journal of Biomaterials Applications volume 37, issue 2, page 195-203 ISSN 0885-3282 1530-8022 |
op_rights |
http://journals.sagepub.com/page/policies/text-and-data-mining-license |
op_doi |
https://doi.org/10.1177/08853282221080525 |
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Journal of Biomaterials Applications |
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37 |
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2 |
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195 |
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203 |
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1810438742490480640 |