Circannual Rhythm in Body Temperature, Torpor, and Sensitivity to A 1 Adenosine Receptor Agonist in Arctic Ground Squirrels
A 1 adenosine receptor (A 1 AR) activation within the central nervous system induces torpor, but in obligate hibernators such as the arctic ground squirrel (AGS; Urocitellus parryii), A 1 AR stimulation induces torpor only during the hibernation season, suggesting a seasonal increase in sensitivity...
Published in: | Journal of Biological Rhythms |
---|---|
Main Authors: | , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
SAGE Publications
2013
|
Subjects: | |
Online Access: | http://dx.doi.org/10.1177/0748730413490667 http://journals.sagepub.com/doi/pdf/10.1177/0748730413490667 http://journals.sagepub.com/doi/full-xml/10.1177/0748730413490667 |
id |
crsagepubl:10.1177/0748730413490667 |
---|---|
record_format |
openpolar |
spelling |
crsagepubl:10.1177/0748730413490667 2024-06-23T07:49:00+00:00 Circannual Rhythm in Body Temperature, Torpor, and Sensitivity to A 1 Adenosine Receptor Agonist in Arctic Ground Squirrels Olson, Jasmine M. Jinka, Tulasi R. Larson, Lindy K. Danielson, Jeffrey J. Moore, Jeanette T. Carpluck, JoAnna Drew, Kelly L. 2013 http://dx.doi.org/10.1177/0748730413490667 http://journals.sagepub.com/doi/pdf/10.1177/0748730413490667 http://journals.sagepub.com/doi/full-xml/10.1177/0748730413490667 en eng SAGE Publications http://journals.sagepub.com/page/policies/text-and-data-mining-license Journal of Biological Rhythms volume 28, issue 3, page 201-207 ISSN 0748-7304 1552-4531 journal-article 2013 crsagepubl https://doi.org/10.1177/0748730413490667 2024-06-11T04:32:15Z A 1 adenosine receptor (A 1 AR) activation within the central nervous system induces torpor, but in obligate hibernators such as the arctic ground squirrel (AGS; Urocitellus parryii), A 1 AR stimulation induces torpor only during the hibernation season, suggesting a seasonal increase in sensitivity to A 1 AR signaling. The purpose of this research was to investigate the relationship between body temperature (T b ) and sensitivity to an adenosine A 1 receptor agonist in AGS. We tested the hypothesis that increased sensitivity in A 1 AR signaling would lead to lower T b in euthermic animals during the hibernation season when compared with the summer season. We further predicted that if a decrease in euthermic T b reflects increased sensitivity to A 1 AR activation, then it should likewise predict spontaneous torpor. We used subcutaneous IPTT-300 transponders to monitor T b in AGS housed under constant ambient conditions (12:12 L:D, 18 °C) for up to 16 months. These animals displayed an obvious rhythm in euthermic T b that cycled with a period of approximately 8 months. Synchrony in the T b rhythm within the group was lost after several months of constant L:D conditions; however, individual rhythms in T b continued to show clear sine wave–like waxing and waning. AGS displayed spontaneous torpor only during troughs in euthermic T b . To assess sensitivity to A 1 AR activation, AGS were administered the A 1 AR agonist N 6 -cyclohexyladenosine (CHA, 0.1 mg/kg, ip), and subcutaneous T b was monitored. AGS administered CHA during a seasonal minimum in euthermic T b showed a greater drug-induced decrease in T b (1.6 ± 0.3 °C) than did AGS administered CHA during a peak in euthermic T b (0.4 ± 0.3 °C). These results provide evidence for a circannual rhythm in T b that is associated with increased sensitivity to A 1 AR signaling and correlates with the onset of torpor. Article in Journal/Newspaper Arctic ground squirrel Arctic Urocitellus parryii SAGE Publications Arctic Journal of Biological Rhythms 28 3 201 207 |
institution |
Open Polar |
collection |
SAGE Publications |
op_collection_id |
crsagepubl |
language |
English |
description |
A 1 adenosine receptor (A 1 AR) activation within the central nervous system induces torpor, but in obligate hibernators such as the arctic ground squirrel (AGS; Urocitellus parryii), A 1 AR stimulation induces torpor only during the hibernation season, suggesting a seasonal increase in sensitivity to A 1 AR signaling. The purpose of this research was to investigate the relationship between body temperature (T b ) and sensitivity to an adenosine A 1 receptor agonist in AGS. We tested the hypothesis that increased sensitivity in A 1 AR signaling would lead to lower T b in euthermic animals during the hibernation season when compared with the summer season. We further predicted that if a decrease in euthermic T b reflects increased sensitivity to A 1 AR activation, then it should likewise predict spontaneous torpor. We used subcutaneous IPTT-300 transponders to monitor T b in AGS housed under constant ambient conditions (12:12 L:D, 18 °C) for up to 16 months. These animals displayed an obvious rhythm in euthermic T b that cycled with a period of approximately 8 months. Synchrony in the T b rhythm within the group was lost after several months of constant L:D conditions; however, individual rhythms in T b continued to show clear sine wave–like waxing and waning. AGS displayed spontaneous torpor only during troughs in euthermic T b . To assess sensitivity to A 1 AR activation, AGS were administered the A 1 AR agonist N 6 -cyclohexyladenosine (CHA, 0.1 mg/kg, ip), and subcutaneous T b was monitored. AGS administered CHA during a seasonal minimum in euthermic T b showed a greater drug-induced decrease in T b (1.6 ± 0.3 °C) than did AGS administered CHA during a peak in euthermic T b (0.4 ± 0.3 °C). These results provide evidence for a circannual rhythm in T b that is associated with increased sensitivity to A 1 AR signaling and correlates with the onset of torpor. |
format |
Article in Journal/Newspaper |
author |
Olson, Jasmine M. Jinka, Tulasi R. Larson, Lindy K. Danielson, Jeffrey J. Moore, Jeanette T. Carpluck, JoAnna Drew, Kelly L. |
spellingShingle |
Olson, Jasmine M. Jinka, Tulasi R. Larson, Lindy K. Danielson, Jeffrey J. Moore, Jeanette T. Carpluck, JoAnna Drew, Kelly L. Circannual Rhythm in Body Temperature, Torpor, and Sensitivity to A 1 Adenosine Receptor Agonist in Arctic Ground Squirrels |
author_facet |
Olson, Jasmine M. Jinka, Tulasi R. Larson, Lindy K. Danielson, Jeffrey J. Moore, Jeanette T. Carpluck, JoAnna Drew, Kelly L. |
author_sort |
Olson, Jasmine M. |
title |
Circannual Rhythm in Body Temperature, Torpor, and Sensitivity to A 1 Adenosine Receptor Agonist in Arctic Ground Squirrels |
title_short |
Circannual Rhythm in Body Temperature, Torpor, and Sensitivity to A 1 Adenosine Receptor Agonist in Arctic Ground Squirrels |
title_full |
Circannual Rhythm in Body Temperature, Torpor, and Sensitivity to A 1 Adenosine Receptor Agonist in Arctic Ground Squirrels |
title_fullStr |
Circannual Rhythm in Body Temperature, Torpor, and Sensitivity to A 1 Adenosine Receptor Agonist in Arctic Ground Squirrels |
title_full_unstemmed |
Circannual Rhythm in Body Temperature, Torpor, and Sensitivity to A 1 Adenosine Receptor Agonist in Arctic Ground Squirrels |
title_sort |
circannual rhythm in body temperature, torpor, and sensitivity to a 1 adenosine receptor agonist in arctic ground squirrels |
publisher |
SAGE Publications |
publishDate |
2013 |
url |
http://dx.doi.org/10.1177/0748730413490667 http://journals.sagepub.com/doi/pdf/10.1177/0748730413490667 http://journals.sagepub.com/doi/full-xml/10.1177/0748730413490667 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic ground squirrel Arctic Urocitellus parryii |
genre_facet |
Arctic ground squirrel Arctic Urocitellus parryii |
op_source |
Journal of Biological Rhythms volume 28, issue 3, page 201-207 ISSN 0748-7304 1552-4531 |
op_rights |
http://journals.sagepub.com/page/policies/text-and-data-mining-license |
op_doi |
https://doi.org/10.1177/0748730413490667 |
container_title |
Journal of Biological Rhythms |
container_volume |
28 |
container_issue |
3 |
container_start_page |
201 |
op_container_end_page |
207 |
_version_ |
1802639285618212864 |