Levamisole Activates Several Innate Immune Factors in Scophthalmus Maximus (L.) (Teleostei)
Levamisole, originally synthesized as an anti-helminthic, has been widely used in human and veterinary medicine as an immunomodulator or adjuvant. However, data on its use in fish are scarce, and no information is available for turbot. To study the effects of levamisole treatment on the innate immun...
Published in: | International Journal of Immunopathology and Pharmacology |
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crsagepubl:10.1177/039463200601900403 2024-05-19T07:48:09+00:00 Levamisole Activates Several Innate Immune Factors in Scophthalmus Maximus (L.) (Teleostei) Alvarez-Pellitero, P. Sitjà-Bobadilla, A. Bermúdez, R. Quiroga, M.I. 2006 http://dx.doi.org/10.1177/039463200601900403 http://journals.sagepub.com/doi/pdf/10.1177/039463200601900403 en eng SAGE Publications http://journals.sagepub.com/page/policies/text-and-data-mining-license International Journal of Immunopathology and Pharmacology volume 19, issue 4, page 727-738 ISSN 2058-7384 2058-7384 journal-article 2006 crsagepubl https://doi.org/10.1177/039463200601900403 2024-04-25T08:12:02Z Levamisole, originally synthesized as an anti-helminthic, has been widely used in human and veterinary medicine as an immunomodulator or adjuvant. However, data on its use in fish are scarce, and no information is available for turbot. To study the effects of levamisole treatment on the innate immune system of juvenile turbot, two different doses (D1=500 mg/kg; D2=250 mg/kg dry food) were orally administered for 2 weeks and samplings were performed at −10, 14, 28, 49 and 77 days post treatment (p.t.). Biometrical, haematological, histological and immunological data were obtained. Specific growth rate was higher in the medicated groups than in the control (C), but the difference was statistically significant only for D1 fish at day 49 p.t. The leucocytes/trombocytes ratio was significantly higher in D1 than in C fish at 14 days p.t., but decreased subsequently. At most samplings, the percentage of the circulating lymphocytes was lower and that of the progranulocytes was higher in the medicated fish than in the C ones. The percentage offish with high haemotopoietic activity in the kidney was clearly higher in D1 and D2 fish than in C ones at some sampling points. The respiratory burst activity of blood leucocytes was significantly higher in D1 fish than in C ones in all samplings, except at day 77 p.t. when control fish experienced a rebound effect. In all medicated fish, an initial increase of such activity was observed, followed by a further decrease. Their serum peroxidases followed a contrary pattern, with a decrease in the second sampling and a subsequent and non-significant recovery, a situation also observed for serum lysozyme and complement. Therefore, oral levamisole treatment actually affects some turbot immune factors, although stimulation or depression can occur depending on the considered factor and the administered dose. These results point out the interest of further studies on the mechanisms involved in the levamisole action for its adequate use as immunomodulator. Article in Journal/Newspaper Scophthalmus maximus Turbot SAGE Publications International Journal of Immunopathology and Pharmacology 19 4 727 738 |
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English |
description |
Levamisole, originally synthesized as an anti-helminthic, has been widely used in human and veterinary medicine as an immunomodulator or adjuvant. However, data on its use in fish are scarce, and no information is available for turbot. To study the effects of levamisole treatment on the innate immune system of juvenile turbot, two different doses (D1=500 mg/kg; D2=250 mg/kg dry food) were orally administered for 2 weeks and samplings were performed at −10, 14, 28, 49 and 77 days post treatment (p.t.). Biometrical, haematological, histological and immunological data were obtained. Specific growth rate was higher in the medicated groups than in the control (C), but the difference was statistically significant only for D1 fish at day 49 p.t. The leucocytes/trombocytes ratio was significantly higher in D1 than in C fish at 14 days p.t., but decreased subsequently. At most samplings, the percentage of the circulating lymphocytes was lower and that of the progranulocytes was higher in the medicated fish than in the C ones. The percentage offish with high haemotopoietic activity in the kidney was clearly higher in D1 and D2 fish than in C ones at some sampling points. The respiratory burst activity of blood leucocytes was significantly higher in D1 fish than in C ones in all samplings, except at day 77 p.t. when control fish experienced a rebound effect. In all medicated fish, an initial increase of such activity was observed, followed by a further decrease. Their serum peroxidases followed a contrary pattern, with a decrease in the second sampling and a subsequent and non-significant recovery, a situation also observed for serum lysozyme and complement. Therefore, oral levamisole treatment actually affects some turbot immune factors, although stimulation or depression can occur depending on the considered factor and the administered dose. These results point out the interest of further studies on the mechanisms involved in the levamisole action for its adequate use as immunomodulator. |
format |
Article in Journal/Newspaper |
author |
Alvarez-Pellitero, P. Sitjà-Bobadilla, A. Bermúdez, R. Quiroga, M.I. |
spellingShingle |
Alvarez-Pellitero, P. Sitjà-Bobadilla, A. Bermúdez, R. Quiroga, M.I. Levamisole Activates Several Innate Immune Factors in Scophthalmus Maximus (L.) (Teleostei) |
author_facet |
Alvarez-Pellitero, P. Sitjà-Bobadilla, A. Bermúdez, R. Quiroga, M.I. |
author_sort |
Alvarez-Pellitero, P. |
title |
Levamisole Activates Several Innate Immune Factors in Scophthalmus Maximus (L.) (Teleostei) |
title_short |
Levamisole Activates Several Innate Immune Factors in Scophthalmus Maximus (L.) (Teleostei) |
title_full |
Levamisole Activates Several Innate Immune Factors in Scophthalmus Maximus (L.) (Teleostei) |
title_fullStr |
Levamisole Activates Several Innate Immune Factors in Scophthalmus Maximus (L.) (Teleostei) |
title_full_unstemmed |
Levamisole Activates Several Innate Immune Factors in Scophthalmus Maximus (L.) (Teleostei) |
title_sort |
levamisole activates several innate immune factors in scophthalmus maximus (l.) (teleostei) |
publisher |
SAGE Publications |
publishDate |
2006 |
url |
http://dx.doi.org/10.1177/039463200601900403 http://journals.sagepub.com/doi/pdf/10.1177/039463200601900403 |
genre |
Scophthalmus maximus Turbot |
genre_facet |
Scophthalmus maximus Turbot |
op_source |
International Journal of Immunopathology and Pharmacology volume 19, issue 4, page 727-738 ISSN 2058-7384 2058-7384 |
op_rights |
http://journals.sagepub.com/page/policies/text-and-data-mining-license |
op_doi |
https://doi.org/10.1177/039463200601900403 |
container_title |
International Journal of Immunopathology and Pharmacology |
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19 |
container_issue |
4 |
container_start_page |
727 |
op_container_end_page |
738 |
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1799488653554089984 |