Histopathologic and Immunocytochemical Studies of Distemper in Harbor Porpoises
During 1988 thousands of harbor seals ( Phoca vitulina) died in European seas as a result of morbillivirus infection. Six harbor porpoises ( Phocoena phocoena) found stranded on the coast of Northern Ireland in late 1988 were submitted to our laboratory for necropsy. Pneumonia was the main necropsy...
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1991
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crsagepubl:10.1177/030098589102800101 2024-06-23T07:56:11+00:00 Histopathologic and Immunocytochemical Studies of Distemper in Harbor Porpoises Kennedy, S. Smyth, J. A. Cush, P. F. McAliskey, M. McCullough, S. J. Rima, B. K. 1991 http://dx.doi.org/10.1177/030098589102800101 http://journals.sagepub.com/doi/pdf/10.1177/030098589102800101 en eng SAGE Publications http://journals.sagepub.com/page/policies/text-and-data-mining-license Veterinary Pathology volume 28, issue 1, page 1-7 ISSN 0300-9858 1544-2217 journal-article 1991 crsagepubl https://doi.org/10.1177/030098589102800101 2024-06-11T04:31:46Z During 1988 thousands of harbor seals ( Phoca vitulina) died in European seas as a result of morbillivirus infection. Six harbor porpoises ( Phocoena phocoena) found stranded on the coast of Northern Ireland in late 1988 were submitted to our laboratory for necropsy. Pneumonia was the main necropsy finding in three of these animals. Microscopic lung lesions characterized by necrosis of bronchial and bronchiolar epithelium and infiltration of alveoli with leukocytes, lymphoid cells, macrophages, and multinucleate syncytia were seen in all six porpoises. Cytoplasmic and nuclear acidophilic inclusions characteristic of morbillivirus infection were common in bronchial and bronchiolar epithelial cells and in alveolar macrophages and syncytia. Brain alterations included degeneration and necrosis of neurons, microglial infiltration, and perivascular cuffing. There were cytoplasmic and nuclear acidophilic inclusions in many neurons. Immunoperoxidase staining of morbillivirus antigen was seen in many tissues including lung, brain, spleen, and urinary bladder. Alterations in our porpoises were similar to those seen in distemper in seals and many species of terrestrial mammals. Systemic viral disease has not previously been documented in Cetacea. Article in Journal/Newspaper Phoca vitulina Phocoena phocoena SAGE Publications Veterinary Pathology 28 1 1 7 |
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SAGE Publications |
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English |
description |
During 1988 thousands of harbor seals ( Phoca vitulina) died in European seas as a result of morbillivirus infection. Six harbor porpoises ( Phocoena phocoena) found stranded on the coast of Northern Ireland in late 1988 were submitted to our laboratory for necropsy. Pneumonia was the main necropsy finding in three of these animals. Microscopic lung lesions characterized by necrosis of bronchial and bronchiolar epithelium and infiltration of alveoli with leukocytes, lymphoid cells, macrophages, and multinucleate syncytia were seen in all six porpoises. Cytoplasmic and nuclear acidophilic inclusions characteristic of morbillivirus infection were common in bronchial and bronchiolar epithelial cells and in alveolar macrophages and syncytia. Brain alterations included degeneration and necrosis of neurons, microglial infiltration, and perivascular cuffing. There were cytoplasmic and nuclear acidophilic inclusions in many neurons. Immunoperoxidase staining of morbillivirus antigen was seen in many tissues including lung, brain, spleen, and urinary bladder. Alterations in our porpoises were similar to those seen in distemper in seals and many species of terrestrial mammals. Systemic viral disease has not previously been documented in Cetacea. |
format |
Article in Journal/Newspaper |
author |
Kennedy, S. Smyth, J. A. Cush, P. F. McAliskey, M. McCullough, S. J. Rima, B. K. |
spellingShingle |
Kennedy, S. Smyth, J. A. Cush, P. F. McAliskey, M. McCullough, S. J. Rima, B. K. Histopathologic and Immunocytochemical Studies of Distemper in Harbor Porpoises |
author_facet |
Kennedy, S. Smyth, J. A. Cush, P. F. McAliskey, M. McCullough, S. J. Rima, B. K. |
author_sort |
Kennedy, S. |
title |
Histopathologic and Immunocytochemical Studies of Distemper in Harbor Porpoises |
title_short |
Histopathologic and Immunocytochemical Studies of Distemper in Harbor Porpoises |
title_full |
Histopathologic and Immunocytochemical Studies of Distemper in Harbor Porpoises |
title_fullStr |
Histopathologic and Immunocytochemical Studies of Distemper in Harbor Porpoises |
title_full_unstemmed |
Histopathologic and Immunocytochemical Studies of Distemper in Harbor Porpoises |
title_sort |
histopathologic and immunocytochemical studies of distemper in harbor porpoises |
publisher |
SAGE Publications |
publishDate |
1991 |
url |
http://dx.doi.org/10.1177/030098589102800101 http://journals.sagepub.com/doi/pdf/10.1177/030098589102800101 |
genre |
Phoca vitulina Phocoena phocoena |
genre_facet |
Phoca vitulina Phocoena phocoena |
op_source |
Veterinary Pathology volume 28, issue 1, page 1-7 ISSN 0300-9858 1544-2217 |
op_rights |
http://journals.sagepub.com/page/policies/text-and-data-mining-license |
op_doi |
https://doi.org/10.1177/030098589102800101 |
container_title |
Veterinary Pathology |
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28 |
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1 |
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1 |
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7 |
_version_ |
1802649108361510912 |