Histopathologic and Immunocytochemical Studies of Distemper in Seals
Thousands of harbor seals ( Phoca vitulina) died in European seas during 1988. Respiratory distress and oculonasal discharge were common clinical signs. We necropsied 76 affected seals. The main necropsy finding was severe pneumonia. Microscopic lung changes were characterized by proliferation of ty...
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crsagepubl:10.1177/030098588902600201 2024-09-30T14:41:21+00:00 Histopathologic and Immunocytochemical Studies of Distemper in Seals Kennedy, S. Smyth, J. A. Cush, P. F. Duignan, P. Platten, M. McCullough, S. J. Allan, G. M. 1989 http://dx.doi.org/10.1177/030098588902600201 https://journals.sagepub.com/doi/pdf/10.1177/030098588902600201 en eng SAGE Publications https://journals.sagepub.com/page/policies/text-and-data-mining-license Veterinary Pathology volume 26, issue 2, page 97-103 ISSN 0300-9858 1544-2217 journal-article 1989 crsagepubl https://doi.org/10.1177/030098588902600201 2024-09-10T04:25:27Z Thousands of harbor seals ( Phoca vitulina) died in European seas during 1988. Respiratory distress and oculonasal discharge were common clinical signs. We necropsied 76 affected seals. The main necropsy finding was severe pneumonia. Microscopic lung changes were characterized by proliferation of type II pneumocytes, filling of alveolar lumina with serofibrinous exudate, leukocytes, and macrophages, and necrosis of bronchial and bronchiolar epithelium. Intracytoplasmic and intranuclear acidophilic inclusion bodies characteristic of morbillivirus infection were seen in bronchial and bronchiolar epithelial cells. Microscopic lesions of non-suppurative demyelinating encephalitis were seen in the brain. There was degeneration and necrosis of neurons, focal gliosis, perivascular cuffing, and patchy demyelination. Many neurons and astrocytes contained intracytoplasmic and intranuclear inclusions. Using an immunoperoxidase technique, we detected morbillivirus antigen in many tissues including lung, brain, spleen, and urinary bladder. The origin of the seal morbillivirus is unknown. Article in Journal/Newspaper Phoca vitulina SAGE Publications Veterinary Pathology 26 2 97 103 |
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Open Polar |
collection |
SAGE Publications |
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language |
English |
description |
Thousands of harbor seals ( Phoca vitulina) died in European seas during 1988. Respiratory distress and oculonasal discharge were common clinical signs. We necropsied 76 affected seals. The main necropsy finding was severe pneumonia. Microscopic lung changes were characterized by proliferation of type II pneumocytes, filling of alveolar lumina with serofibrinous exudate, leukocytes, and macrophages, and necrosis of bronchial and bronchiolar epithelium. Intracytoplasmic and intranuclear acidophilic inclusion bodies characteristic of morbillivirus infection were seen in bronchial and bronchiolar epithelial cells. Microscopic lesions of non-suppurative demyelinating encephalitis were seen in the brain. There was degeneration and necrosis of neurons, focal gliosis, perivascular cuffing, and patchy demyelination. Many neurons and astrocytes contained intracytoplasmic and intranuclear inclusions. Using an immunoperoxidase technique, we detected morbillivirus antigen in many tissues including lung, brain, spleen, and urinary bladder. The origin of the seal morbillivirus is unknown. |
format |
Article in Journal/Newspaper |
author |
Kennedy, S. Smyth, J. A. Cush, P. F. Duignan, P. Platten, M. McCullough, S. J. Allan, G. M. |
spellingShingle |
Kennedy, S. Smyth, J. A. Cush, P. F. Duignan, P. Platten, M. McCullough, S. J. Allan, G. M. Histopathologic and Immunocytochemical Studies of Distemper in Seals |
author_facet |
Kennedy, S. Smyth, J. A. Cush, P. F. Duignan, P. Platten, M. McCullough, S. J. Allan, G. M. |
author_sort |
Kennedy, S. |
title |
Histopathologic and Immunocytochemical Studies of Distemper in Seals |
title_short |
Histopathologic and Immunocytochemical Studies of Distemper in Seals |
title_full |
Histopathologic and Immunocytochemical Studies of Distemper in Seals |
title_fullStr |
Histopathologic and Immunocytochemical Studies of Distemper in Seals |
title_full_unstemmed |
Histopathologic and Immunocytochemical Studies of Distemper in Seals |
title_sort |
histopathologic and immunocytochemical studies of distemper in seals |
publisher |
SAGE Publications |
publishDate |
1989 |
url |
http://dx.doi.org/10.1177/030098588902600201 https://journals.sagepub.com/doi/pdf/10.1177/030098588902600201 |
genre |
Phoca vitulina |
genre_facet |
Phoca vitulina |
op_source |
Veterinary Pathology volume 26, issue 2, page 97-103 ISSN 0300-9858 1544-2217 |
op_rights |
https://journals.sagepub.com/page/policies/text-and-data-mining-license |
op_doi |
https://doi.org/10.1177/030098588902600201 |
container_title |
Veterinary Pathology |
container_volume |
26 |
container_issue |
2 |
container_start_page |
97 |
op_container_end_page |
103 |
_version_ |
1811643751253147648 |