Multifocal Necrotizing Myopathy in Northern Elephant Seal ( Mirounga angustirostris ) Pups, San Miguel Island, California
A field study addressing causes of mortality in freshly dead northern elephant seals ( Mirounga angustirostris, Gill, 1866) was conducted on San Miguel Island, California, in February 2015. Necropsies were performed on 18 pups ranging in age from stillbirths to approximately 7 to 8 weeks. The primar...
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crsagepubl:10.1177/0300985818790268 2023-05-15T16:05:20+02:00 Multifocal Necrotizing Myopathy in Northern Elephant Seal ( Mirounga angustirostris ) Pups, San Miguel Island, California Spraker, Terry R. Kuzmina, Tetiana A. Lyons, Eugene T. DeLong, Robert L. Simeone, Claire Veeramachaneni, D. N. Rao 2018 http://dx.doi.org/10.1177/0300985818790268 http://journals.sagepub.com/doi/pdf/10.1177/0300985818790268 http://journals.sagepub.com/doi/full-xml/10.1177/0300985818790268 en eng SAGE Publications http://journals.sagepub.com/page/policies/text-and-data-mining-license Veterinary Pathology volume 56, issue 1, page 143-151 ISSN 0300-9858 1544-2217 General Veterinary journal-article 2018 crsagepubl https://doi.org/10.1177/0300985818790268 2022-09-21T19:48:39Z A field study addressing causes of mortality in freshly dead northern elephant seals ( Mirounga angustirostris, Gill, 1866) was conducted on San Miguel Island, California, in February 2015. Necropsies were performed on 18 pups ranging in age from stillbirths to approximately 7 to 8 weeks. The primary gross diagnoses in these pups included trauma, myopathy, starvation/emaciation, infections, congenital anomalies, and perinatal mortality. However, 6 (33%) had a previously unrecognized myopathy characterized by multiple white streaks that were most obvious within the inner layer of the abdominal wall and the small innermost ventral intercostal muscles. Following histological examination, 2 more pups from San Miguel Island and 6 pups from The Marine Mammal Center (Sausalito, California) were found to have similar lesions. Histologically, the lesions within the skeletal muscles were characterized by a multifocal polyphasic, mild to severe, acute to subacute necrotizing myopathy with mineralization. Acute necrosis and degeneration characterized by pyknotic nuclei, eosinophilic cytoplasm and cytoplasmic vacuolization were found in smooth muscle myocytes within the urinary bladder and digestive system. Degeneration of myocytes was present in the tunica media of a few small- to medium-sized vessels and was characterized by a vacuolar degeneration and occasionally necrosis. This condition has been termed multifocal necrotizing myopathy. A cause of this myopathy was not identified. Article in Journal/Newspaper Elephant Seal Elephant Seals SAGE Publications (via Crossref) San Miguel ENVELOPE(-57.467,-57.467,-63.650,-63.650) Veterinary Pathology 56 1 143 151 |
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English |
topic |
General Veterinary |
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General Veterinary Spraker, Terry R. Kuzmina, Tetiana A. Lyons, Eugene T. DeLong, Robert L. Simeone, Claire Veeramachaneni, D. N. Rao Multifocal Necrotizing Myopathy in Northern Elephant Seal ( Mirounga angustirostris ) Pups, San Miguel Island, California |
topic_facet |
General Veterinary |
description |
A field study addressing causes of mortality in freshly dead northern elephant seals ( Mirounga angustirostris, Gill, 1866) was conducted on San Miguel Island, California, in February 2015. Necropsies were performed on 18 pups ranging in age from stillbirths to approximately 7 to 8 weeks. The primary gross diagnoses in these pups included trauma, myopathy, starvation/emaciation, infections, congenital anomalies, and perinatal mortality. However, 6 (33%) had a previously unrecognized myopathy characterized by multiple white streaks that were most obvious within the inner layer of the abdominal wall and the small innermost ventral intercostal muscles. Following histological examination, 2 more pups from San Miguel Island and 6 pups from The Marine Mammal Center (Sausalito, California) were found to have similar lesions. Histologically, the lesions within the skeletal muscles were characterized by a multifocal polyphasic, mild to severe, acute to subacute necrotizing myopathy with mineralization. Acute necrosis and degeneration characterized by pyknotic nuclei, eosinophilic cytoplasm and cytoplasmic vacuolization were found in smooth muscle myocytes within the urinary bladder and digestive system. Degeneration of myocytes was present in the tunica media of a few small- to medium-sized vessels and was characterized by a vacuolar degeneration and occasionally necrosis. This condition has been termed multifocal necrotizing myopathy. A cause of this myopathy was not identified. |
format |
Article in Journal/Newspaper |
author |
Spraker, Terry R. Kuzmina, Tetiana A. Lyons, Eugene T. DeLong, Robert L. Simeone, Claire Veeramachaneni, D. N. Rao |
author_facet |
Spraker, Terry R. Kuzmina, Tetiana A. Lyons, Eugene T. DeLong, Robert L. Simeone, Claire Veeramachaneni, D. N. Rao |
author_sort |
Spraker, Terry R. |
title |
Multifocal Necrotizing Myopathy in Northern Elephant Seal ( Mirounga angustirostris ) Pups, San Miguel Island, California |
title_short |
Multifocal Necrotizing Myopathy in Northern Elephant Seal ( Mirounga angustirostris ) Pups, San Miguel Island, California |
title_full |
Multifocal Necrotizing Myopathy in Northern Elephant Seal ( Mirounga angustirostris ) Pups, San Miguel Island, California |
title_fullStr |
Multifocal Necrotizing Myopathy in Northern Elephant Seal ( Mirounga angustirostris ) Pups, San Miguel Island, California |
title_full_unstemmed |
Multifocal Necrotizing Myopathy in Northern Elephant Seal ( Mirounga angustirostris ) Pups, San Miguel Island, California |
title_sort |
multifocal necrotizing myopathy in northern elephant seal ( mirounga angustirostris ) pups, san miguel island, california |
publisher |
SAGE Publications |
publishDate |
2018 |
url |
http://dx.doi.org/10.1177/0300985818790268 http://journals.sagepub.com/doi/pdf/10.1177/0300985818790268 http://journals.sagepub.com/doi/full-xml/10.1177/0300985818790268 |
long_lat |
ENVELOPE(-57.467,-57.467,-63.650,-63.650) |
geographic |
San Miguel |
geographic_facet |
San Miguel |
genre |
Elephant Seal Elephant Seals |
genre_facet |
Elephant Seal Elephant Seals |
op_source |
Veterinary Pathology volume 56, issue 1, page 143-151 ISSN 0300-9858 1544-2217 |
op_rights |
http://journals.sagepub.com/page/policies/text-and-data-mining-license |
op_doi |
https://doi.org/10.1177/0300985818790268 |
container_title |
Veterinary Pathology |
container_volume |
56 |
container_issue |
1 |
container_start_page |
143 |
op_container_end_page |
151 |
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1766401229998522368 |