Successful Treatment of Malignant Trophoblastic Diseases in a Small Oncologic Unit
Between 1962 and 1983 a total of 26 patients with malignant trophoblastic disease were diagnosed in northern Finland. The incidence of this disease was 1:21,000 pregnancies. Eight patients had choriocarcinoma and 18 an invasive mole. Clinically, 15 patients belonged to the nonmetastatic and 11 to th...
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crsagepubl:10.1177/030089168607200615 2023-05-15T17:42:30+02:00 Successful Treatment of Malignant Trophoblastic Diseases in a Small Oncologic Unit Kuoppala, Tapio Kivinen, Seppo Kauppila, Antti 1986 http://dx.doi.org/10.1177/030089168607200615 http://journals.sagepub.com/doi/pdf/10.1177/030089168607200615 en eng SAGE Publications http://journals.sagepub.com/page/policies/text-and-data-mining-license Tumori Journal volume 72, issue 6, page 625-628 ISSN 0300-8916 2038-2529 Cancer Research Oncology General Medicine journal-article 1986 crsagepubl https://doi.org/10.1177/030089168607200615 2022-04-14T04:42:27Z Between 1962 and 1983 a total of 26 patients with malignant trophoblastic disease were diagnosed in northern Finland. The incidence of this disease was 1:21,000 pregnancies. Eight patients had choriocarcinoma and 18 an invasive mole. Clinically, 15 patients belonged to the nonmetastatic and 11 to the metastatic group. Of the latter, 4 patients belonged to the Iow-and 7 to the high-risk categories. During the first years of the study period, cytotoxic chemotherapy, mostly single-drug therapy, was often complemented with adjunctive surgery and/or irradiation. During recent years, single- or multidrug chemotherapy was supplemented with surgery in only one case with chemotherapy-resistant pulmonary metastases. All 26 patients are alive and disease-free, and after therapy 6 of them have given birth to 1-3 children. Our results suggest that malignant trophoblastic diseases can be successfully treated also in small centers of gynecologic oncology with up-to-date knowledge of the principles of modern cytotoxic chemotherapy. Article in Journal/Newspaper Northern Finland SAGE Publications (via Crossref) Tumori Journal 72 6 625 628 |
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SAGE Publications (via Crossref) |
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English |
topic |
Cancer Research Oncology General Medicine |
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Cancer Research Oncology General Medicine Kuoppala, Tapio Kivinen, Seppo Kauppila, Antti Successful Treatment of Malignant Trophoblastic Diseases in a Small Oncologic Unit |
topic_facet |
Cancer Research Oncology General Medicine |
description |
Between 1962 and 1983 a total of 26 patients with malignant trophoblastic disease were diagnosed in northern Finland. The incidence of this disease was 1:21,000 pregnancies. Eight patients had choriocarcinoma and 18 an invasive mole. Clinically, 15 patients belonged to the nonmetastatic and 11 to the metastatic group. Of the latter, 4 patients belonged to the Iow-and 7 to the high-risk categories. During the first years of the study period, cytotoxic chemotherapy, mostly single-drug therapy, was often complemented with adjunctive surgery and/or irradiation. During recent years, single- or multidrug chemotherapy was supplemented with surgery in only one case with chemotherapy-resistant pulmonary metastases. All 26 patients are alive and disease-free, and after therapy 6 of them have given birth to 1-3 children. Our results suggest that malignant trophoblastic diseases can be successfully treated also in small centers of gynecologic oncology with up-to-date knowledge of the principles of modern cytotoxic chemotherapy. |
format |
Article in Journal/Newspaper |
author |
Kuoppala, Tapio Kivinen, Seppo Kauppila, Antti |
author_facet |
Kuoppala, Tapio Kivinen, Seppo Kauppila, Antti |
author_sort |
Kuoppala, Tapio |
title |
Successful Treatment of Malignant Trophoblastic Diseases in a Small Oncologic Unit |
title_short |
Successful Treatment of Malignant Trophoblastic Diseases in a Small Oncologic Unit |
title_full |
Successful Treatment of Malignant Trophoblastic Diseases in a Small Oncologic Unit |
title_fullStr |
Successful Treatment of Malignant Trophoblastic Diseases in a Small Oncologic Unit |
title_full_unstemmed |
Successful Treatment of Malignant Trophoblastic Diseases in a Small Oncologic Unit |
title_sort |
successful treatment of malignant trophoblastic diseases in a small oncologic unit |
publisher |
SAGE Publications |
publishDate |
1986 |
url |
http://dx.doi.org/10.1177/030089168607200615 http://journals.sagepub.com/doi/pdf/10.1177/030089168607200615 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_source |
Tumori Journal volume 72, issue 6, page 625-628 ISSN 0300-8916 2038-2529 |
op_rights |
http://journals.sagepub.com/page/policies/text-and-data-mining-license |
op_doi |
https://doi.org/10.1177/030089168607200615 |
container_title |
Tumori Journal |
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72 |
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6 |
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625 |
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628 |
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1766144367163080704 |