Transdermal Glyceryl Trinitrate to Allow Peripheral Total Parenteral Nutrition: A Double-Blind Placebo Controlled Feasibility Study
Seventy-two consecutive patients requiring total parenteral nutrition (TPN) were randomized to two groups. Group A received daily a peripheral intravenous regimen which provided 10 g nitrogen and 1400 non-nitrogen kcal (5.9 MJ). Group B received daily a peripheral intravenous regimen which delivered...
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Language: | English |
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1991
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Online Access: | http://dx.doi.org/10.1177/014107689108400205 http://journals.sagepub.com/doi/pdf/10.1177/014107689108400205 |
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crsagepubl:10.1177/014107689108400205 2023-05-15T16:32:13+02:00 Transdermal Glyceryl Trinitrate to Allow Peripheral Total Parenteral Nutrition: A Double-Blind Placebo Controlled Feasibility Study Khawaja, H T Williams, J D Weaver, P C 1991 http://dx.doi.org/10.1177/014107689108400205 http://journals.sagepub.com/doi/pdf/10.1177/014107689108400205 en eng SAGE Publications http://journals.sagepub.com/page/policies/text-and-data-mining-license Journal of the Royal Society of Medicine volume 84, issue 2, page 69-72 ISSN 0141-0768 1758-1095 General Medicine journal-article 1991 crsagepubl https://doi.org/10.1177/014107689108400205 2022-07-03T16:08:43Z Seventy-two consecutive patients requiring total parenteral nutrition (TPN) were randomized to two groups. Group A received daily a peripheral intravenous regimen which provided 10 g nitrogen and 1400 non-nitrogen kcal (5.9 MJ). Group B received daily a peripheral intravenous regimen which delivered 9.4 g nitrogen and 1900 non-nitrogen kcal (8.0 MJ). Each group was further randomized to receive a self-adhesive patch of transdermal glyceryl trinitrate (GTN) or an identical placebo. Infusion survival was the main end-point. For group A, the median time of infusion survival was 74 h (range: 58–100) in the control group compared with 108 h (range: 68–156) in the group that received transdermal GTN (P < 0.001). For group B, the median infusion survival was 67 h (range: 46–92) in the control group compared with 103 h (range: 66–151) in the treatment group (P < 0.001). TPN is feasible via peripheral veins and the incidence of infusion failure can be effectively reduced by transdermal GTN. Article in Journal/Newspaper GTN-P SAGE Publications (via Crossref) Journal of the Royal Society of Medicine 84 2 69 72 |
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Open Polar |
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SAGE Publications (via Crossref) |
op_collection_id |
crsagepubl |
language |
English |
topic |
General Medicine |
spellingShingle |
General Medicine Khawaja, H T Williams, J D Weaver, P C Transdermal Glyceryl Trinitrate to Allow Peripheral Total Parenteral Nutrition: A Double-Blind Placebo Controlled Feasibility Study |
topic_facet |
General Medicine |
description |
Seventy-two consecutive patients requiring total parenteral nutrition (TPN) were randomized to two groups. Group A received daily a peripheral intravenous regimen which provided 10 g nitrogen and 1400 non-nitrogen kcal (5.9 MJ). Group B received daily a peripheral intravenous regimen which delivered 9.4 g nitrogen and 1900 non-nitrogen kcal (8.0 MJ). Each group was further randomized to receive a self-adhesive patch of transdermal glyceryl trinitrate (GTN) or an identical placebo. Infusion survival was the main end-point. For group A, the median time of infusion survival was 74 h (range: 58–100) in the control group compared with 108 h (range: 68–156) in the group that received transdermal GTN (P < 0.001). For group B, the median infusion survival was 67 h (range: 46–92) in the control group compared with 103 h (range: 66–151) in the treatment group (P < 0.001). TPN is feasible via peripheral veins and the incidence of infusion failure can be effectively reduced by transdermal GTN. |
format |
Article in Journal/Newspaper |
author |
Khawaja, H T Williams, J D Weaver, P C |
author_facet |
Khawaja, H T Williams, J D Weaver, P C |
author_sort |
Khawaja, H T |
title |
Transdermal Glyceryl Trinitrate to Allow Peripheral Total Parenteral Nutrition: A Double-Blind Placebo Controlled Feasibility Study |
title_short |
Transdermal Glyceryl Trinitrate to Allow Peripheral Total Parenteral Nutrition: A Double-Blind Placebo Controlled Feasibility Study |
title_full |
Transdermal Glyceryl Trinitrate to Allow Peripheral Total Parenteral Nutrition: A Double-Blind Placebo Controlled Feasibility Study |
title_fullStr |
Transdermal Glyceryl Trinitrate to Allow Peripheral Total Parenteral Nutrition: A Double-Blind Placebo Controlled Feasibility Study |
title_full_unstemmed |
Transdermal Glyceryl Trinitrate to Allow Peripheral Total Parenteral Nutrition: A Double-Blind Placebo Controlled Feasibility Study |
title_sort |
transdermal glyceryl trinitrate to allow peripheral total parenteral nutrition: a double-blind placebo controlled feasibility study |
publisher |
SAGE Publications |
publishDate |
1991 |
url |
http://dx.doi.org/10.1177/014107689108400205 http://journals.sagepub.com/doi/pdf/10.1177/014107689108400205 |
genre |
GTN-P |
genre_facet |
GTN-P |
op_source |
Journal of the Royal Society of Medicine volume 84, issue 2, page 69-72 ISSN 0141-0768 1758-1095 |
op_rights |
http://journals.sagepub.com/page/policies/text-and-data-mining-license |
op_doi |
https://doi.org/10.1177/014107689108400205 |
container_title |
Journal of the Royal Society of Medicine |
container_volume |
84 |
container_issue |
2 |
container_start_page |
69 |
op_container_end_page |
72 |
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1766021971460489216 |