Association of Maternal Vitamin D Deficiency with Early Childhood Caries
Alaska Native (AN) children experience one of the highest reported rates of severe early childhood caries (S-ECC). Serum vitamin D concentrations in AN childbearing women in the Yukon Kuskokwim Delta (YKD) region have decreased since the 1960s to currently low levels, related to a decrease in tradit...
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crsagepubl:10.1177/0022034519834518 2024-06-23T07:54:25+00:00 Association of Maternal Vitamin D Deficiency with Early Childhood Caries Singleton, R. Day, G. Thomas, T. Schroth, R. Klejka, J. Lenaker, D. Berner, J. National Institute of General Medical Sciences U.S. Environmental Protection Agency 2019 http://dx.doi.org/10.1177/0022034519834518 http://journals.sagepub.com/doi/pdf/10.1177/0022034519834518 http://journals.sagepub.com/doi/full-xml/10.1177/0022034519834518 en eng SAGE Publications http://journals.sagepub.com/page/policies/text-and-data-mining-license Journal of Dental Research volume 98, issue 5, page 549-555 ISSN 0022-0345 1544-0591 journal-article 2019 crsagepubl https://doi.org/10.1177/0022034519834518 2024-06-11T04:29:47Z Alaska Native (AN) children experience one of the highest reported rates of severe early childhood caries (S-ECC). Serum vitamin D concentrations in AN childbearing women in the Yukon Kuskokwim Delta (YKD) region have decreased since the 1960s to currently low levels, related to a decrease in traditional marine diet. Recent studies suggest an association between prenatal vitamin D (25(OH)D) concentrations in mothers and S-ECC in their infants. We used independent t tests to analyze the influence of prenatal 25(OH)D levels in YKD AN mothers on S-ECC in their children using data collected in the Maternal Organics Monitoring Study (MOMS). Maternal 25(OH)D levels were assessed at prenatal visits and in cord blood. We queried electronic dental records to assess early childhood caries (ECC) status using highest decayed, missing, filled, primary teeth (dmft) scores at 12 to 59 mo of age. We examined prenatal and cord blood for 76 and 57 mother/infant pairs, respectively. Children 12 to 35 mo of age with “deficient” cord blood (25(OH)D <30 nmol/L) had a mean dmft score twice as high as children who were “nondeficient” at birth (9.3 vs. 4.7; P = 0.002). There was no significant difference in mean dmft scores for children aged 36 to 59 mo with deficient versus nondeficient cord blood 25(OH)D (10.9 vs. 8.7 P = 0.14). There was no significant difference in mean dmft scores for children aged 12 to 35 mo whose mothers had “sufficient” versus “insufficient” 25(OH)D during prenatal visits (9.0 vs. 7.4; P = 0.48). In this small sample, children with deficient vitamin D levels in cord blood had a dmft score at 12 to 35 mo 2-fold higher than children with nondeficient cord blood. Maternal 25(OH)D may influence the primary dentition, and improving vitamin D status in pregnant women might affect ECC rates in their infants. Article in Journal/Newspaper Kuskokwim Alaska Yukon SAGE Publications Yukon Journal of Dental Research 98 5 549 555 |
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SAGE Publications |
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English |
description |
Alaska Native (AN) children experience one of the highest reported rates of severe early childhood caries (S-ECC). Serum vitamin D concentrations in AN childbearing women in the Yukon Kuskokwim Delta (YKD) region have decreased since the 1960s to currently low levels, related to a decrease in traditional marine diet. Recent studies suggest an association between prenatal vitamin D (25(OH)D) concentrations in mothers and S-ECC in their infants. We used independent t tests to analyze the influence of prenatal 25(OH)D levels in YKD AN mothers on S-ECC in their children using data collected in the Maternal Organics Monitoring Study (MOMS). Maternal 25(OH)D levels were assessed at prenatal visits and in cord blood. We queried electronic dental records to assess early childhood caries (ECC) status using highest decayed, missing, filled, primary teeth (dmft) scores at 12 to 59 mo of age. We examined prenatal and cord blood for 76 and 57 mother/infant pairs, respectively. Children 12 to 35 mo of age with “deficient” cord blood (25(OH)D <30 nmol/L) had a mean dmft score twice as high as children who were “nondeficient” at birth (9.3 vs. 4.7; P = 0.002). There was no significant difference in mean dmft scores for children aged 36 to 59 mo with deficient versus nondeficient cord blood 25(OH)D (10.9 vs. 8.7 P = 0.14). There was no significant difference in mean dmft scores for children aged 12 to 35 mo whose mothers had “sufficient” versus “insufficient” 25(OH)D during prenatal visits (9.0 vs. 7.4; P = 0.48). In this small sample, children with deficient vitamin D levels in cord blood had a dmft score at 12 to 35 mo 2-fold higher than children with nondeficient cord blood. Maternal 25(OH)D may influence the primary dentition, and improving vitamin D status in pregnant women might affect ECC rates in their infants. |
author2 |
National Institute of General Medical Sciences U.S. Environmental Protection Agency |
format |
Article in Journal/Newspaper |
author |
Singleton, R. Day, G. Thomas, T. Schroth, R. Klejka, J. Lenaker, D. Berner, J. |
spellingShingle |
Singleton, R. Day, G. Thomas, T. Schroth, R. Klejka, J. Lenaker, D. Berner, J. Association of Maternal Vitamin D Deficiency with Early Childhood Caries |
author_facet |
Singleton, R. Day, G. Thomas, T. Schroth, R. Klejka, J. Lenaker, D. Berner, J. |
author_sort |
Singleton, R. |
title |
Association of Maternal Vitamin D Deficiency with Early Childhood Caries |
title_short |
Association of Maternal Vitamin D Deficiency with Early Childhood Caries |
title_full |
Association of Maternal Vitamin D Deficiency with Early Childhood Caries |
title_fullStr |
Association of Maternal Vitamin D Deficiency with Early Childhood Caries |
title_full_unstemmed |
Association of Maternal Vitamin D Deficiency with Early Childhood Caries |
title_sort |
association of maternal vitamin d deficiency with early childhood caries |
publisher |
SAGE Publications |
publishDate |
2019 |
url |
http://dx.doi.org/10.1177/0022034519834518 http://journals.sagepub.com/doi/pdf/10.1177/0022034519834518 http://journals.sagepub.com/doi/full-xml/10.1177/0022034519834518 |
geographic |
Yukon |
geographic_facet |
Yukon |
genre |
Kuskokwim Alaska Yukon |
genre_facet |
Kuskokwim Alaska Yukon |
op_source |
Journal of Dental Research volume 98, issue 5, page 549-555 ISSN 0022-0345 1544-0591 |
op_rights |
http://journals.sagepub.com/page/policies/text-and-data-mining-license |
op_doi |
https://doi.org/10.1177/0022034519834518 |
container_title |
Journal of Dental Research |
container_volume |
98 |
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5 |
container_start_page |
549 |
op_container_end_page |
555 |
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1802646575505211392 |