NIDDM-Y in First Nation Children in Canada
Prevalence of NIDDM-Y in children in many First Nations communities in Manitoba and northwestern Ontario is now severalfold greater than the prevalence of IDDM in the general pediatric population. Rates vary among First Nations communities in Canada owing to inconsistent screening programs and diffe...
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Online Access: | http://dx.doi.org/10.1177/000992289803700205 http://journals.sagepub.com/doi/pdf/10.1177/000992289803700205 |
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crsagepubl:10.1177/000992289803700205 2024-06-16T07:39:58+00:00 NIDDM-Y in First Nation Children in Canada Dean, Heather 1998 http://dx.doi.org/10.1177/000992289803700205 http://journals.sagepub.com/doi/pdf/10.1177/000992289803700205 en eng SAGE Publications http://journals.sagepub.com/page/policies/text-and-data-mining-license Clinical Pediatrics volume 37, issue 2, page 89-96 ISSN 0009-9228 1938-2707 journal-article 1998 crsagepubl https://doi.org/10.1177/000992289803700205 2024-05-19T12:57:28Z Prevalence of NIDDM-Y in children in many First Nations communities in Manitoba and northwestern Ontario is now severalfold greater than the prevalence of IDDM in the general pediatric population. Rates vary among First Nations communities in Canada owing to inconsistent screening programs and different genetic risk. The number of undiagnosed, asymptomatic cases is predicted to be at least 2× greater than the known cases. Serious complications of diabetes are known to occur in the early third decade of life and within 10 years of diagnosis. Long-term follow-up data are scarce. Nonpharmacologic management in youths has been successful in short-term studies but generally unsuccessful in achieving long-term acceptable glycemic control. The safety and efficacy of pharma cologic interventions have not been proven in this age group, particularly the prepubertal group. NIDDM-Y fits the WHO criteria for a disease appropriate for screening. There is an urgent need for consistent community-based screening programs and randomized controlled trials of pharmacologic interventions to test the safety and efficacy of these agents in primary prevention and secondary prevention of complications in youths. Clin Pediatr. 1998;37:89-96 Article in Journal/Newspaper First Nations SAGE Publications Canada Clinical Pediatrics 37 2 89 96 |
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SAGE Publications |
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English |
description |
Prevalence of NIDDM-Y in children in many First Nations communities in Manitoba and northwestern Ontario is now severalfold greater than the prevalence of IDDM in the general pediatric population. Rates vary among First Nations communities in Canada owing to inconsistent screening programs and different genetic risk. The number of undiagnosed, asymptomatic cases is predicted to be at least 2× greater than the known cases. Serious complications of diabetes are known to occur in the early third decade of life and within 10 years of diagnosis. Long-term follow-up data are scarce. Nonpharmacologic management in youths has been successful in short-term studies but generally unsuccessful in achieving long-term acceptable glycemic control. The safety and efficacy of pharma cologic interventions have not been proven in this age group, particularly the prepubertal group. NIDDM-Y fits the WHO criteria for a disease appropriate for screening. There is an urgent need for consistent community-based screening programs and randomized controlled trials of pharmacologic interventions to test the safety and efficacy of these agents in primary prevention and secondary prevention of complications in youths. Clin Pediatr. 1998;37:89-96 |
format |
Article in Journal/Newspaper |
author |
Dean, Heather |
spellingShingle |
Dean, Heather NIDDM-Y in First Nation Children in Canada |
author_facet |
Dean, Heather |
author_sort |
Dean, Heather |
title |
NIDDM-Y in First Nation Children in Canada |
title_short |
NIDDM-Y in First Nation Children in Canada |
title_full |
NIDDM-Y in First Nation Children in Canada |
title_fullStr |
NIDDM-Y in First Nation Children in Canada |
title_full_unstemmed |
NIDDM-Y in First Nation Children in Canada |
title_sort |
niddm-y in first nation children in canada |
publisher |
SAGE Publications |
publishDate |
1998 |
url |
http://dx.doi.org/10.1177/000992289803700205 http://journals.sagepub.com/doi/pdf/10.1177/000992289803700205 |
geographic |
Canada |
geographic_facet |
Canada |
genre |
First Nations |
genre_facet |
First Nations |
op_source |
Clinical Pediatrics volume 37, issue 2, page 89-96 ISSN 0009-9228 1938-2707 |
op_rights |
http://journals.sagepub.com/page/policies/text-and-data-mining-license |
op_doi |
https://doi.org/10.1177/000992289803700205 |
container_title |
Clinical Pediatrics |
container_volume |
37 |
container_issue |
2 |
container_start_page |
89 |
op_container_end_page |
96 |
_version_ |
1802006791833255936 |