Tissue-specific metabolic enzyme levels covary with whole-animal metabolic rates and life-history loci via epistatic effects
Metabolic rates, including standard (SMR) and maximum (MMR) metabolic rate have often been linked with life-history strategies. Variation in context- and tissue-level metabolism underlying SMR and MMR may thus provide a physiological basis for life-history variation. This raises a hypothesis that ti...
Published in: | Philosophical Transactions of the Royal Society B: Biological Sciences |
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Online Access: | http://dx.doi.org/10.1098/rstb.2022.0482 https://royalsocietypublishing.org/doi/pdf/10.1098/rstb.2022.0482 https://royalsocietypublishing.org/doi/full-xml/10.1098/rstb.2022.0482 |
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crroyalsociety:10.1098/rstb.2022.0482 2024-06-02T08:03:41+00:00 Tissue-specific metabolic enzyme levels covary with whole-animal metabolic rates and life-history loci via epistatic effects Prokkola, Jenni M. Chew, Kuan Kiat Anttila, Katja Maamela, Katja S. Yildiz, Atakan Åsheim, Eirik R. Primmer, Craig R. Aykanat, Tutku Natural Resources Institute Finland Societas pro Fauna et Flora Fennica Academy of Finland H2020 European Research Council Helsingin Yliopisto 2024 http://dx.doi.org/10.1098/rstb.2022.0482 https://royalsocietypublishing.org/doi/pdf/10.1098/rstb.2022.0482 https://royalsocietypublishing.org/doi/full-xml/10.1098/rstb.2022.0482 en eng The Royal Society https://royalsociety.org/journals/ethics-policies/data-sharing-mining/ Philosophical Transactions of the Royal Society B: Biological Sciences volume 379, issue 1896 ISSN 0962-8436 1471-2970 journal-article 2024 crroyalsociety https://doi.org/10.1098/rstb.2022.0482 2024-05-07T14:16:39Z Metabolic rates, including standard (SMR) and maximum (MMR) metabolic rate have often been linked with life-history strategies. Variation in context- and tissue-level metabolism underlying SMR and MMR may thus provide a physiological basis for life-history variation. This raises a hypothesis that tissue-specific metabolism covaries with whole-animal metabolic rates and is genetically linked to life history. In Atlantic salmon ( Salmo salar ), variation in two loci, vgll3 and six6 , affects life history via age-at-maturity as well as MMR. Here, using individuals with known SMR and MMR with different vgll3 and six6 genotype combinations, we measured proxies of mitochondrial density and anaerobic metabolism, i.e. maximal activities of the mitochondrial citrate synthase (CS) and lactate dehydrogenase (LDH) enzymes, in four tissues (heart, intestine, liver, white muscle) across low- and high-food regimes. We found enzymatic activities were related to metabolic rates, mainly SMR, in the intestine and heart. Individual loci were not associated with the enzymatic activities, but we found epistatic effects and genotype-by-environment interactions in CS activity in the heart and epistasis in LDH activity in the intestine. These effects suggest that mitochondrial density and anaerobic capacity in the heart and intestine may partly mediate variation in metabolic rates and life history via age-at-maturity. This article is part of the theme issue ‘The evolutionary significance of variation in metabolic rates’. Article in Journal/Newspaper Atlantic salmon Salmo salar The Royal Society Philosophical Transactions of the Royal Society B: Biological Sciences 379 1896 |
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Open Polar |
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The Royal Society |
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crroyalsociety |
language |
English |
description |
Metabolic rates, including standard (SMR) and maximum (MMR) metabolic rate have often been linked with life-history strategies. Variation in context- and tissue-level metabolism underlying SMR and MMR may thus provide a physiological basis for life-history variation. This raises a hypothesis that tissue-specific metabolism covaries with whole-animal metabolic rates and is genetically linked to life history. In Atlantic salmon ( Salmo salar ), variation in two loci, vgll3 and six6 , affects life history via age-at-maturity as well as MMR. Here, using individuals with known SMR and MMR with different vgll3 and six6 genotype combinations, we measured proxies of mitochondrial density and anaerobic metabolism, i.e. maximal activities of the mitochondrial citrate synthase (CS) and lactate dehydrogenase (LDH) enzymes, in four tissues (heart, intestine, liver, white muscle) across low- and high-food regimes. We found enzymatic activities were related to metabolic rates, mainly SMR, in the intestine and heart. Individual loci were not associated with the enzymatic activities, but we found epistatic effects and genotype-by-environment interactions in CS activity in the heart and epistasis in LDH activity in the intestine. These effects suggest that mitochondrial density and anaerobic capacity in the heart and intestine may partly mediate variation in metabolic rates and life history via age-at-maturity. This article is part of the theme issue ‘The evolutionary significance of variation in metabolic rates’. |
author2 |
Natural Resources Institute Finland Societas pro Fauna et Flora Fennica Academy of Finland H2020 European Research Council Helsingin Yliopisto |
format |
Article in Journal/Newspaper |
author |
Prokkola, Jenni M. Chew, Kuan Kiat Anttila, Katja Maamela, Katja S. Yildiz, Atakan Åsheim, Eirik R. Primmer, Craig R. Aykanat, Tutku |
spellingShingle |
Prokkola, Jenni M. Chew, Kuan Kiat Anttila, Katja Maamela, Katja S. Yildiz, Atakan Åsheim, Eirik R. Primmer, Craig R. Aykanat, Tutku Tissue-specific metabolic enzyme levels covary with whole-animal metabolic rates and life-history loci via epistatic effects |
author_facet |
Prokkola, Jenni M. Chew, Kuan Kiat Anttila, Katja Maamela, Katja S. Yildiz, Atakan Åsheim, Eirik R. Primmer, Craig R. Aykanat, Tutku |
author_sort |
Prokkola, Jenni M. |
title |
Tissue-specific metabolic enzyme levels covary with whole-animal metabolic rates and life-history loci via epistatic effects |
title_short |
Tissue-specific metabolic enzyme levels covary with whole-animal metabolic rates and life-history loci via epistatic effects |
title_full |
Tissue-specific metabolic enzyme levels covary with whole-animal metabolic rates and life-history loci via epistatic effects |
title_fullStr |
Tissue-specific metabolic enzyme levels covary with whole-animal metabolic rates and life-history loci via epistatic effects |
title_full_unstemmed |
Tissue-specific metabolic enzyme levels covary with whole-animal metabolic rates and life-history loci via epistatic effects |
title_sort |
tissue-specific metabolic enzyme levels covary with whole-animal metabolic rates and life-history loci via epistatic effects |
publisher |
The Royal Society |
publishDate |
2024 |
url |
http://dx.doi.org/10.1098/rstb.2022.0482 https://royalsocietypublishing.org/doi/pdf/10.1098/rstb.2022.0482 https://royalsocietypublishing.org/doi/full-xml/10.1098/rstb.2022.0482 |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_source |
Philosophical Transactions of the Royal Society B: Biological Sciences volume 379, issue 1896 ISSN 0962-8436 1471-2970 |
op_rights |
https://royalsociety.org/journals/ethics-policies/data-sharing-mining/ |
op_doi |
https://doi.org/10.1098/rstb.2022.0482 |
container_title |
Philosophical Transactions of the Royal Society B: Biological Sciences |
container_volume |
379 |
container_issue |
1896 |
_version_ |
1800748286403936256 |