Platelet — vessel wall interaction: influence of diet
The interaction of platelets with the vessel wall is influenced by the diet. Of major importance is the dietary polyunsaturated fatty acids (PUFA). Epidemiological evidence from Greenland Eskimos with low incidences of acute myocardial infarction has drawn attention to the role of the n — 3 PUFA fam...
Published in: | Philosophical Transactions of the Royal Society of London. B, Biological Sciences |
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Format: | Article in Journal/Newspaper |
Language: | English |
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The Royal Society
1981
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Online Access: | http://dx.doi.org/10.1098/rstb.1981.0113 https://royalsocietypublishing.org/doi/pdf/10.1098/rstb.1981.0113 |
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crroyalsociety:10.1098/rstb.1981.0113 2024-06-23T07:52:33+00:00 Platelet — vessel wall interaction: influence of diet 1981 http://dx.doi.org/10.1098/rstb.1981.0113 https://royalsocietypublishing.org/doi/pdf/10.1098/rstb.1981.0113 en eng The Royal Society https://royalsociety.org/journals/ethics-policies/data-sharing-mining/ Philosophical Transactions of the Royal Society of London. B, Biological Sciences volume 294, issue 1072, page 373-381 ISSN 0080-4622 2054-0280 journal-article 1981 crroyalsociety https://doi.org/10.1098/rstb.1981.0113 2024-06-10T04:15:06Z The interaction of platelets with the vessel wall is influenced by the diet. Of major importance is the dietary polyunsaturated fatty acids (PUFA). Epidemiological evidence from Greenland Eskimos with low incidences of acute myocardial infarction has drawn attention to the role of the n — 3 PUFA family. Experiments in vitro have demonstrated an anti-aggregatory effect of eicosapentaenoic acid (EPA). However, EPA does not inhibit vascular prostacyclin production. Antiaggregatory substances generated from EPA have not yet been demonstrated in vivo . Studies in vivo in both animals and humans have demonstrated an antithrombotic effect of EPA. In a study where volunteers were given 6 g EPA per day for 3 weeks, moderate decreases in collagen-induced and ADP-induced platelet aggregation, lower thromboxane B 2 (TXB 2 ) synthesis and prolongation of bleeding time were found. These observations indicate that dietary factors modulate the interaction of platelets and the vessel wall. Dietary advice aiming at lowering the incidence of ischaemic diseases must include this aspect. This necessitates a re-evaluation of advice hitherto given to the population in general. Article in Journal/Newspaper eskimo* Greenland The Royal Society Greenland Philosophical Transactions of the Royal Society of London. B, Biological Sciences 294 1072 373 381 |
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Open Polar |
collection |
The Royal Society |
op_collection_id |
crroyalsociety |
language |
English |
description |
The interaction of platelets with the vessel wall is influenced by the diet. Of major importance is the dietary polyunsaturated fatty acids (PUFA). Epidemiological evidence from Greenland Eskimos with low incidences of acute myocardial infarction has drawn attention to the role of the n — 3 PUFA family. Experiments in vitro have demonstrated an anti-aggregatory effect of eicosapentaenoic acid (EPA). However, EPA does not inhibit vascular prostacyclin production. Antiaggregatory substances generated from EPA have not yet been demonstrated in vivo . Studies in vivo in both animals and humans have demonstrated an antithrombotic effect of EPA. In a study where volunteers were given 6 g EPA per day for 3 weeks, moderate decreases in collagen-induced and ADP-induced platelet aggregation, lower thromboxane B 2 (TXB 2 ) synthesis and prolongation of bleeding time were found. These observations indicate that dietary factors modulate the interaction of platelets and the vessel wall. Dietary advice aiming at lowering the incidence of ischaemic diseases must include this aspect. This necessitates a re-evaluation of advice hitherto given to the population in general. |
format |
Article in Journal/Newspaper |
title |
Platelet — vessel wall interaction: influence of diet |
spellingShingle |
Platelet — vessel wall interaction: influence of diet |
title_short |
Platelet — vessel wall interaction: influence of diet |
title_full |
Platelet — vessel wall interaction: influence of diet |
title_fullStr |
Platelet — vessel wall interaction: influence of diet |
title_full_unstemmed |
Platelet — vessel wall interaction: influence of diet |
title_sort |
platelet — vessel wall interaction: influence of diet |
publisher |
The Royal Society |
publishDate |
1981 |
url |
http://dx.doi.org/10.1098/rstb.1981.0113 https://royalsocietypublishing.org/doi/pdf/10.1098/rstb.1981.0113 |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
eskimo* Greenland |
genre_facet |
eskimo* Greenland |
op_source |
Philosophical Transactions of the Royal Society of London. B, Biological Sciences volume 294, issue 1072, page 373-381 ISSN 0080-4622 2054-0280 |
op_rights |
https://royalsociety.org/journals/ethics-policies/data-sharing-mining/ |
op_doi |
https://doi.org/10.1098/rstb.1981.0113 |
container_title |
Philosophical Transactions of the Royal Society of London. B, Biological Sciences |
container_volume |
294 |
container_issue |
1072 |
container_start_page |
373 |
op_container_end_page |
381 |
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1802643877957468160 |