Full allogeneic fusion of embryos in a holothuroid echinoderm
Whole-body chimaeras (organisms composed of genetically distinct cells) have been directly observed in modular/colonial organisms (e.g. corals, sponges, ascidians); whereas in unitary deuterostosmes (including mammals) they have only been detected indirectly through molecular analysis. Here, we docu...
Published in: | Proceedings of the Royal Society B: Biological Sciences |
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Online Access: | http://dx.doi.org/10.1098/rspb.2018.0339 https://royalsocietypublishing.org/doi/pdf/10.1098/rspb.2018.0339 https://royalsocietypublishing.org/doi/full-xml/10.1098/rspb.2018.0339 |
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crroyalsociety:10.1098/rspb.2018.0339 2024-06-02T08:05:39+00:00 Full allogeneic fusion of embryos in a holothuroid echinoderm Gianasi, Bruno L. Hamel, Jean-François Mercier, Annie Canada Foundation for Innovation Canadian Centre for Fisheries and Innovation Department of Fisheries and Aquaculture (DFA) of Newfoundland and Labrador Research and Development Corporation Natural Sciences and Engineering Research Council of Canada 2018 http://dx.doi.org/10.1098/rspb.2018.0339 https://royalsocietypublishing.org/doi/pdf/10.1098/rspb.2018.0339 https://royalsocietypublishing.org/doi/full-xml/10.1098/rspb.2018.0339 en eng The Royal Society https://royalsociety.org/journals/ethics-policies/data-sharing-mining/ Proceedings of the Royal Society B: Biological Sciences volume 285, issue 1879, page 20180339 ISSN 0962-8452 1471-2954 journal-article 2018 crroyalsociety https://doi.org/10.1098/rspb.2018.0339 2024-05-07T14:16:16Z Whole-body chimaeras (organisms composed of genetically distinct cells) have been directly observed in modular/colonial organisms (e.g. corals, sponges, ascidians); whereas in unitary deuterostosmes (including mammals) they have only been detected indirectly through molecular analysis. Here, we document for the first time the step-by-step development of whole-body chimaeras in the holothuroid Cucumaria frondosa , a unitary deuterostome belonging to the phylum Echinodermata. To the best of our knowledge, this is the most derived unitary metazoan in which direct investigation of zygote fusibility has been undertaken. Fusion occurred among hatched blastulae, never during earlier (unhatched) or later (larval) stages. The fully fused chimaeric propagules were two to five times larger than non-chimaeric embryos. Fusion was positively correlated with propagule density and facilitated by the natural tendency of early embryos to agglomerate. The discovery of natural chimaerism in a unitary deuterostome that possesses large externally fertilized eggs provides a framework to explore key aspects of evolutionary biology, histocompatibility and cell transplantation in biomedical research. Article in Journal/Newspaper Cucumaria frondosa The Royal Society Proceedings of the Royal Society B: Biological Sciences 285 1879 20180339 |
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The Royal Society |
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English |
description |
Whole-body chimaeras (organisms composed of genetically distinct cells) have been directly observed in modular/colonial organisms (e.g. corals, sponges, ascidians); whereas in unitary deuterostosmes (including mammals) they have only been detected indirectly through molecular analysis. Here, we document for the first time the step-by-step development of whole-body chimaeras in the holothuroid Cucumaria frondosa , a unitary deuterostome belonging to the phylum Echinodermata. To the best of our knowledge, this is the most derived unitary metazoan in which direct investigation of zygote fusibility has been undertaken. Fusion occurred among hatched blastulae, never during earlier (unhatched) or later (larval) stages. The fully fused chimaeric propagules were two to five times larger than non-chimaeric embryos. Fusion was positively correlated with propagule density and facilitated by the natural tendency of early embryos to agglomerate. The discovery of natural chimaerism in a unitary deuterostome that possesses large externally fertilized eggs provides a framework to explore key aspects of evolutionary biology, histocompatibility and cell transplantation in biomedical research. |
author2 |
Canada Foundation for Innovation Canadian Centre for Fisheries and Innovation Department of Fisheries and Aquaculture (DFA) of Newfoundland and Labrador Research and Development Corporation Natural Sciences and Engineering Research Council of Canada |
format |
Article in Journal/Newspaper |
author |
Gianasi, Bruno L. Hamel, Jean-François Mercier, Annie |
spellingShingle |
Gianasi, Bruno L. Hamel, Jean-François Mercier, Annie Full allogeneic fusion of embryos in a holothuroid echinoderm |
author_facet |
Gianasi, Bruno L. Hamel, Jean-François Mercier, Annie |
author_sort |
Gianasi, Bruno L. |
title |
Full allogeneic fusion of embryos in a holothuroid echinoderm |
title_short |
Full allogeneic fusion of embryos in a holothuroid echinoderm |
title_full |
Full allogeneic fusion of embryos in a holothuroid echinoderm |
title_fullStr |
Full allogeneic fusion of embryos in a holothuroid echinoderm |
title_full_unstemmed |
Full allogeneic fusion of embryos in a holothuroid echinoderm |
title_sort |
full allogeneic fusion of embryos in a holothuroid echinoderm |
publisher |
The Royal Society |
publishDate |
2018 |
url |
http://dx.doi.org/10.1098/rspb.2018.0339 https://royalsocietypublishing.org/doi/pdf/10.1098/rspb.2018.0339 https://royalsocietypublishing.org/doi/full-xml/10.1098/rspb.2018.0339 |
genre |
Cucumaria frondosa |
genre_facet |
Cucumaria frondosa |
op_source |
Proceedings of the Royal Society B: Biological Sciences volume 285, issue 1879, page 20180339 ISSN 0962-8452 1471-2954 |
op_rights |
https://royalsociety.org/journals/ethics-policies/data-sharing-mining/ |
op_doi |
https://doi.org/10.1098/rspb.2018.0339 |
container_title |
Proceedings of the Royal Society B: Biological Sciences |
container_volume |
285 |
container_issue |
1879 |
container_start_page |
20180339 |
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1800750521531760640 |