Selective upregulation of lipid metabolism in skeletal muscle of foraging juvenile king penguins: an integrative study
The passage from shore to marine life of juvenile penguins represents a major energetic challenge to fuel intense and prolonged demands for thermoregulation and locomotion. Some functional changes developed at this crucial step were investigated by comparing pre-fledging king penguins with sea-accli...
Published in: | Proceedings of the Royal Society B: Biological Sciences |
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Language: | English |
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Online Access: | http://dx.doi.org/10.1098/rspb.2011.2664 https://royalsocietypublishing.org/doi/pdf/10.1098/rspb.2011.2664 https://royalsocietypublishing.org/doi/full-xml/10.1098/rspb.2011.2664 |
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crroyalsociety:10.1098/rspb.2011.2664 2024-06-02T08:09:52+00:00 Selective upregulation of lipid metabolism in skeletal muscle of foraging juvenile king penguins: an integrative study Teulier, Loic Dégletagne, Cyril Rey, Benjamin Tornos, Jérémy Keime, Céline de Dinechin, Marc Raccurt, Mireille Rouanet, Jean-Louis Roussel, Damien Duchamp, Claude 2012 http://dx.doi.org/10.1098/rspb.2011.2664 https://royalsocietypublishing.org/doi/pdf/10.1098/rspb.2011.2664 https://royalsocietypublishing.org/doi/full-xml/10.1098/rspb.2011.2664 en eng The Royal Society https://royalsociety.org/journals/ethics-policies/data-sharing-mining/ Proceedings of the Royal Society B: Biological Sciences volume 279, issue 1737, page 2464-2472 ISSN 0962-8452 1471-2954 journal-article 2012 crroyalsociety https://doi.org/10.1098/rspb.2011.2664 2024-05-07T14:16:45Z The passage from shore to marine life of juvenile penguins represents a major energetic challenge to fuel intense and prolonged demands for thermoregulation and locomotion. Some functional changes developed at this crucial step were investigated by comparing pre-fledging king penguins with sea-acclimatized (SA) juveniles ( Aptenodytes patagonicus ). Transcriptomic analysis of pectoralis muscle biopsies revealed that most genes encoding proteins involved in lipid transport or catabolism were upregulated, while genes involved in carbohydrate metabolism were mostly downregulated in SA birds. Determination of muscle enzymatic activities showed no changes in enzymes involved in the glycolytic pathway, but increased 3-hydroxyacyl-CoA dehydrogenase, an enzyme of the β-oxidation pathway. The respiratory rates of isolated muscle mitochondria were much higher with a substrate arising from lipid metabolism (palmitoyl- l -carnitine) in SA juveniles than in terrestrial controls, while no difference emerged with a substrate arising from carbohydrate metabolism (pyruvate). In vivo , perfusion of a lipid emulsion induced a fourfold larger thermogenic effect in SA than in control juveniles. The present integrative study shows that fuel selection towards lipid oxidation characterizes penguin acclimatization to marine life. Such acclimatization may involve thyroid hormones through their nuclear beta receptor and nuclear coactivators. Article in Journal/Newspaper King Penguins The Royal Society Proceedings of the Royal Society B: Biological Sciences 279 1737 2464 2472 |
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crroyalsociety |
language |
English |
description |
The passage from shore to marine life of juvenile penguins represents a major energetic challenge to fuel intense and prolonged demands for thermoregulation and locomotion. Some functional changes developed at this crucial step were investigated by comparing pre-fledging king penguins with sea-acclimatized (SA) juveniles ( Aptenodytes patagonicus ). Transcriptomic analysis of pectoralis muscle biopsies revealed that most genes encoding proteins involved in lipid transport or catabolism were upregulated, while genes involved in carbohydrate metabolism were mostly downregulated in SA birds. Determination of muscle enzymatic activities showed no changes in enzymes involved in the glycolytic pathway, but increased 3-hydroxyacyl-CoA dehydrogenase, an enzyme of the β-oxidation pathway. The respiratory rates of isolated muscle mitochondria were much higher with a substrate arising from lipid metabolism (palmitoyl- l -carnitine) in SA juveniles than in terrestrial controls, while no difference emerged with a substrate arising from carbohydrate metabolism (pyruvate). In vivo , perfusion of a lipid emulsion induced a fourfold larger thermogenic effect in SA than in control juveniles. The present integrative study shows that fuel selection towards lipid oxidation characterizes penguin acclimatization to marine life. Such acclimatization may involve thyroid hormones through their nuclear beta receptor and nuclear coactivators. |
format |
Article in Journal/Newspaper |
author |
Teulier, Loic Dégletagne, Cyril Rey, Benjamin Tornos, Jérémy Keime, Céline de Dinechin, Marc Raccurt, Mireille Rouanet, Jean-Louis Roussel, Damien Duchamp, Claude |
spellingShingle |
Teulier, Loic Dégletagne, Cyril Rey, Benjamin Tornos, Jérémy Keime, Céline de Dinechin, Marc Raccurt, Mireille Rouanet, Jean-Louis Roussel, Damien Duchamp, Claude Selective upregulation of lipid metabolism in skeletal muscle of foraging juvenile king penguins: an integrative study |
author_facet |
Teulier, Loic Dégletagne, Cyril Rey, Benjamin Tornos, Jérémy Keime, Céline de Dinechin, Marc Raccurt, Mireille Rouanet, Jean-Louis Roussel, Damien Duchamp, Claude |
author_sort |
Teulier, Loic |
title |
Selective upregulation of lipid metabolism in skeletal muscle of foraging juvenile king penguins: an integrative study |
title_short |
Selective upregulation of lipid metabolism in skeletal muscle of foraging juvenile king penguins: an integrative study |
title_full |
Selective upregulation of lipid metabolism in skeletal muscle of foraging juvenile king penguins: an integrative study |
title_fullStr |
Selective upregulation of lipid metabolism in skeletal muscle of foraging juvenile king penguins: an integrative study |
title_full_unstemmed |
Selective upregulation of lipid metabolism in skeletal muscle of foraging juvenile king penguins: an integrative study |
title_sort |
selective upregulation of lipid metabolism in skeletal muscle of foraging juvenile king penguins: an integrative study |
publisher |
The Royal Society |
publishDate |
2012 |
url |
http://dx.doi.org/10.1098/rspb.2011.2664 https://royalsocietypublishing.org/doi/pdf/10.1098/rspb.2011.2664 https://royalsocietypublishing.org/doi/full-xml/10.1098/rspb.2011.2664 |
genre |
King Penguins |
genre_facet |
King Penguins |
op_source |
Proceedings of the Royal Society B: Biological Sciences volume 279, issue 1737, page 2464-2472 ISSN 0962-8452 1471-2954 |
op_rights |
https://royalsociety.org/journals/ethics-policies/data-sharing-mining/ |
op_doi |
https://doi.org/10.1098/rspb.2011.2664 |
container_title |
Proceedings of the Royal Society B: Biological Sciences |
container_volume |
279 |
container_issue |
1737 |
container_start_page |
2464 |
op_container_end_page |
2472 |
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1800755656448278528 |