Natural selection acts on Atlantic salmon major histocompatibility (MH) variability in the wild
Pathogen-driven balancing selection is thought to maintain polymorphism in major histocompatibility (MH) genes. However, there have been few empirical demonstrations of selection acting on MH loci in natural populations. To determine whether natural selection on MH genes has fitness consequences for...
Published in: | Proceedings of the Royal Society B: Biological Sciences |
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crroyalsociety:10.1098/rspb.2006.0053 2024-06-02T08:03:26+00:00 Natural selection acts on Atlantic salmon major histocompatibility (MH) variability in the wild de Eyto, Elvira McGinnity, Philip Consuegra, Sofia Coughlan, Jamie Tufto, Jarle Farrell, Killian Megens, Hendrik-Jan Jordan, William Cross, Tom Stet, René J.M 2007 http://dx.doi.org/10.1098/rspb.2006.0053 https://royalsocietypublishing.org/doi/pdf/10.1098/rspb.2006.0053 https://royalsocietypublishing.org/doi/full-xml/10.1098/rspb.2006.0053 en eng The Royal Society https://royalsociety.org/journals/ethics-policies/data-sharing-mining/ Proceedings of the Royal Society B: Biological Sciences volume 274, issue 1611, page 861-869 ISSN 0962-8452 1471-2954 journal-article 2007 crroyalsociety https://doi.org/10.1098/rspb.2006.0053 2024-05-07T14:16:52Z Pathogen-driven balancing selection is thought to maintain polymorphism in major histocompatibility (MH) genes. However, there have been few empirical demonstrations of selection acting on MH loci in natural populations. To determine whether natural selection on MH genes has fitness consequences for wild Atlantic salmon in natural conditions, we compared observed genotype frequencies of Atlantic salmon ( Salmo salar ) surviving in a river six months after their introduction as eggs with frequencies expected from parental crosses. We found significant differences between expected and observed genotype frequencies at the MH class II alpha locus, but not at a MH class I-linked microsatellite or at seven non-MH-linked microsatellite loci. We therefore conclude that selection at the MH class II alpha locus was a result of disease-mediated natural selection, rather than any demographic event. We also show that survival was associated with additive allelic effects at the MH class II alpha locus. Our results have implications for both the conservation of wild salmon stocks and the management of disease in hatchery fish. We conclude that natural or hatchery populations have the best chance of dealing with episodic and variable disease challenges if MH genetic variation is preserved both within and among populations. Article in Journal/Newspaper Atlantic salmon Salmo salar The Royal Society Proceedings of the Royal Society B: Biological Sciences 274 1611 861 869 |
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Open Polar |
collection |
The Royal Society |
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crroyalsociety |
language |
English |
description |
Pathogen-driven balancing selection is thought to maintain polymorphism in major histocompatibility (MH) genes. However, there have been few empirical demonstrations of selection acting on MH loci in natural populations. To determine whether natural selection on MH genes has fitness consequences for wild Atlantic salmon in natural conditions, we compared observed genotype frequencies of Atlantic salmon ( Salmo salar ) surviving in a river six months after their introduction as eggs with frequencies expected from parental crosses. We found significant differences between expected and observed genotype frequencies at the MH class II alpha locus, but not at a MH class I-linked microsatellite or at seven non-MH-linked microsatellite loci. We therefore conclude that selection at the MH class II alpha locus was a result of disease-mediated natural selection, rather than any demographic event. We also show that survival was associated with additive allelic effects at the MH class II alpha locus. Our results have implications for both the conservation of wild salmon stocks and the management of disease in hatchery fish. We conclude that natural or hatchery populations have the best chance of dealing with episodic and variable disease challenges if MH genetic variation is preserved both within and among populations. |
format |
Article in Journal/Newspaper |
author |
de Eyto, Elvira McGinnity, Philip Consuegra, Sofia Coughlan, Jamie Tufto, Jarle Farrell, Killian Megens, Hendrik-Jan Jordan, William Cross, Tom Stet, René J.M |
spellingShingle |
de Eyto, Elvira McGinnity, Philip Consuegra, Sofia Coughlan, Jamie Tufto, Jarle Farrell, Killian Megens, Hendrik-Jan Jordan, William Cross, Tom Stet, René J.M Natural selection acts on Atlantic salmon major histocompatibility (MH) variability in the wild |
author_facet |
de Eyto, Elvira McGinnity, Philip Consuegra, Sofia Coughlan, Jamie Tufto, Jarle Farrell, Killian Megens, Hendrik-Jan Jordan, William Cross, Tom Stet, René J.M |
author_sort |
de Eyto, Elvira |
title |
Natural selection acts on Atlantic salmon major histocompatibility (MH) variability in the wild |
title_short |
Natural selection acts on Atlantic salmon major histocompatibility (MH) variability in the wild |
title_full |
Natural selection acts on Atlantic salmon major histocompatibility (MH) variability in the wild |
title_fullStr |
Natural selection acts on Atlantic salmon major histocompatibility (MH) variability in the wild |
title_full_unstemmed |
Natural selection acts on Atlantic salmon major histocompatibility (MH) variability in the wild |
title_sort |
natural selection acts on atlantic salmon major histocompatibility (mh) variability in the wild |
publisher |
The Royal Society |
publishDate |
2007 |
url |
http://dx.doi.org/10.1098/rspb.2006.0053 https://royalsocietypublishing.org/doi/pdf/10.1098/rspb.2006.0053 https://royalsocietypublishing.org/doi/full-xml/10.1098/rspb.2006.0053 |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_source |
Proceedings of the Royal Society B: Biological Sciences volume 274, issue 1611, page 861-869 ISSN 0962-8452 1471-2954 |
op_rights |
https://royalsociety.org/journals/ethics-policies/data-sharing-mining/ |
op_doi |
https://doi.org/10.1098/rspb.2006.0053 |
container_title |
Proceedings of the Royal Society B: Biological Sciences |
container_volume |
274 |
container_issue |
1611 |
container_start_page |
861 |
op_container_end_page |
869 |
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1800747955558285312 |