Extraordinarily rapid proliferation of cultured muscle satellite cells from migratory birds

• Published in: Biology Letters
• Main Authors: Young, Kevin G., Regnault, Timothy R. H., Guglielmo, Christopher G.
• Other Authors: NSERC
• Format: Article in Journal/Newspaper
• Language: English
• Published: The Royal Society 2021
• Subjects: Calidris alba; Ruff; Sanderling
• Online Access: http://dx.doi.org/10.1098/rsbl.2021.0200; https://royalsocietypublishing.org/doi/pdf/10.1098/rsbl.2021.0200; https://royalsocietypublishing.org/doi/full-xml/10.1098/rsbl.2021.0200

Migratory birds experience bouts of muscle growth and depletion as they prepare for, and undertake prolonged flight. Our studies of migratory bird muscle physiology in vitro led to the discovery that sanderling ( Calidris alba ) muscle satellite cells proliferate more rapidly than other normal cell lines. Here we determined the proliferation rate of muscle satellite cells isolated from five migratory species (sanderling; ruff, Calidris pugnax western sandpiper, Calidris mauri yellow-rumped warbler, Setophaga coronata Swainson's thrush, Catharus ustulatus ) from two families (shorebirds and songbirds) and with different migratory strategies. Ruff and sanderling satellite cells exhibited rapid proliferation, with population doubling times of 9.3 ± 1.3 and 11.4 ± 2 h, whereas the remaining species' cell doubling times were greater than or equal to 24 h. The results indicate that the rapid proliferation of satellite cells is not associated with total migration distance but may be related to flight bout duration and interact with lifespan.