Here and there, but not everywhere: repeated loss of uncoupling protein 1 in amniotes
Endothermy is an evolutionary innovation in eutherian mammals and birds. In eutherian mammals, UCP1 is a key protein in adaptive nonshivering thermogenesis (NST). Although ucp1 arose early in the vertebrate lineage, the loss of ucp1 was previously documented in several reptile species (including bir...
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crroyalsociety:10.1098/rsbl.2016.0749 2024-10-06T13:51:58+00:00 Here and there, but not everywhere: repeated loss of uncoupling protein 1 in amniotes McGaugh, Suzanne Schwartz, Tonia S. University of Minnesota and Auburn University 2017 http://dx.doi.org/10.1098/rsbl.2016.0749 https://royalsocietypublishing.org/doi/pdf/10.1098/rsbl.2016.0749 https://royalsocietypublishing.org/doi/full-xml/10.1098/rsbl.2016.0749 en eng The Royal Society https://royalsociety.org/journals/ethics-policies/data-sharing-mining/ Biology Letters volume 13, issue 1, page 20160749 ISSN 1744-9561 1744-957X journal-article 2017 crroyalsociety https://doi.org/10.1098/rsbl.2016.0749 2024-09-09T06:01:15Z Endothermy is an evolutionary innovation in eutherian mammals and birds. In eutherian mammals, UCP1 is a key protein in adaptive nonshivering thermogenesis (NST). Although ucp1 arose early in the vertebrate lineage, the loss of ucp1 was previously documented in several reptile species (including birds). Here we determine that ucp1 was lost at the base of the reptile lineage, as we fail to find ucp1 in every major reptile lineage. Furthermore, though UCP1 plays a key role in mammalian NST, we confirm that pig has lost several exons from ucp1 and conclude that pig is not a sole outlier as the only eutherian mammal lineage to do so. Through similarity searches and synteny analysis, we show that ucp1 has also been lost/pseudogenized in Delphinidae (dolphin, orca) and potentially Xenarthra (sloth, armadillo) and Afrotheria (hyrax). These lineages provide models for investigating alternate mechanisms of thermoregulation and energy metabolism in the absence of functional UCP1. Further, the repeated losses of a functional UCP1 suggest the pervasiveness of NST via UCP1 across the mammalian lineage needs re-evaluation. Article in Journal/Newspaper Orca The Royal Society Biology Letters 13 1 20160749 |
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The Royal Society |
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crroyalsociety |
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English |
description |
Endothermy is an evolutionary innovation in eutherian mammals and birds. In eutherian mammals, UCP1 is a key protein in adaptive nonshivering thermogenesis (NST). Although ucp1 arose early in the vertebrate lineage, the loss of ucp1 was previously documented in several reptile species (including birds). Here we determine that ucp1 was lost at the base of the reptile lineage, as we fail to find ucp1 in every major reptile lineage. Furthermore, though UCP1 plays a key role in mammalian NST, we confirm that pig has lost several exons from ucp1 and conclude that pig is not a sole outlier as the only eutherian mammal lineage to do so. Through similarity searches and synteny analysis, we show that ucp1 has also been lost/pseudogenized in Delphinidae (dolphin, orca) and potentially Xenarthra (sloth, armadillo) and Afrotheria (hyrax). These lineages provide models for investigating alternate mechanisms of thermoregulation and energy metabolism in the absence of functional UCP1. Further, the repeated losses of a functional UCP1 suggest the pervasiveness of NST via UCP1 across the mammalian lineage needs re-evaluation. |
author2 |
University of Minnesota and Auburn University |
format |
Article in Journal/Newspaper |
author |
McGaugh, Suzanne Schwartz, Tonia S. |
spellingShingle |
McGaugh, Suzanne Schwartz, Tonia S. Here and there, but not everywhere: repeated loss of uncoupling protein 1 in amniotes |
author_facet |
McGaugh, Suzanne Schwartz, Tonia S. |
author_sort |
McGaugh, Suzanne |
title |
Here and there, but not everywhere: repeated loss of uncoupling protein 1 in amniotes |
title_short |
Here and there, but not everywhere: repeated loss of uncoupling protein 1 in amniotes |
title_full |
Here and there, but not everywhere: repeated loss of uncoupling protein 1 in amniotes |
title_fullStr |
Here and there, but not everywhere: repeated loss of uncoupling protein 1 in amniotes |
title_full_unstemmed |
Here and there, but not everywhere: repeated loss of uncoupling protein 1 in amniotes |
title_sort |
here and there, but not everywhere: repeated loss of uncoupling protein 1 in amniotes |
publisher |
The Royal Society |
publishDate |
2017 |
url |
http://dx.doi.org/10.1098/rsbl.2016.0749 https://royalsocietypublishing.org/doi/pdf/10.1098/rsbl.2016.0749 https://royalsocietypublishing.org/doi/full-xml/10.1098/rsbl.2016.0749 |
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Orca |
genre_facet |
Orca |
op_source |
Biology Letters volume 13, issue 1, page 20160749 ISSN 1744-9561 1744-957X |
op_rights |
https://royalsociety.org/journals/ethics-policies/data-sharing-mining/ |
op_doi |
https://doi.org/10.1098/rsbl.2016.0749 |
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Biology Letters |
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13 |
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1 |
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20160749 |
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1812180279549231104 |