Synthetic DNA binders for fluorescent sensing of thymine glycol-containing DNA duplexes and inhibition of endonuclease activity

Dimethyllumazine (DML)-thiazole orange (TO) conjugates were developed for fluorescence sensing of thymine glycol (Tg)-containing DNAs based on the selective recognition of the A nucleobase opposite the Tg residue.

Bibliographic Details
Published in:Chemical Communications
Main Authors: Sato, Yusuke, Takaku, Yoshihide, Nakano, Toshiaki, Akamatsu, Ken, Inamura, Dai, Nishizawa, Seiichi
Other Authors: Japan Society for the Promotion of Science
Format: Article in Journal/Newspaper
Language:English
Published: Royal Society of Chemistry (RSC) 2023
Subjects:
DML
Online Access:http://dx.doi.org/10.1039/d3cc01501g
http://pubs.rsc.org/en/content/articlepdf/2023/CC/D3CC01501G
Description
Summary:Dimethyllumazine (DML)-thiazole orange (TO) conjugates were developed for fluorescence sensing of thymine glycol (Tg)-containing DNAs based on the selective recognition of the A nucleobase opposite the Tg residue.

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