A subset of memory CD4+ helper T lymphocytes identified by expression of Pgp-1.

• Published in: Journal of Experimental Medicine
• Main Authors: Butterfield, K, Fathman, C G, Budd, R C
• Format: Article in Journal/Newspaper
• Language: English
• Published: Rockefeller University Press 1989
• Subjects: Keyhole; Sperm whale
• Online Access: http://dx.doi.org/10.1084/jem.169.4.1461; https://rupress.org/jem/article-pdf/169/4/1461/1669703/1461.pdf

The Pgp-1 glycoprotein (Ly-24 antigen) is acquired by mature murine T lymphocytes at the time of primary antigen stimulation Pgp-1 was previously shown to be a useful cell surface marker for distinguishing antigen-specific memory CD8+ T lymphocytes after immunization. Here we demonstrate that this observation extends to CD4+ T lymphocytes. Antigen-specific CD4+ T cells in mice immunized with sperm whale myoglobin or keyhole limpet hemocyanin were contained nearly exclusively in the minor Pgp-1+ subset.