Correlation of T cell receptor V beta gene family with MHC restriction.
We have studied a panel of DBA/2 T cell clones specific for sperm whale myoglobin (SpW Mb) for TCR (T cell receptor) beta chain gene expression by FACS analysis using the monoclonal antibodies F23.1 and KJ16 specific for the V beta 8 family of the TCR beta chain genes. Within any given specificity g...
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Rockefeller University Press
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Online Access: | http://dx.doi.org/10.1084/jem.166.2.583 https://rupress.org/jem/article-pdf/166/2/583/1668008/583.pdf |
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crrockefelleruni:10.1084/jem.166.2.583 2024-06-02T08:14:53+00:00 Correlation of T cell receptor V beta gene family with MHC restriction. Morel, P A Livingstone, A M Fathman, C G 1987 http://dx.doi.org/10.1084/jem.166.2.583 https://rupress.org/jem/article-pdf/166/2/583/1668008/583.pdf en eng Rockefeller University Press The Journal of experimental medicine volume 166, issue 2, page 583-588 ISSN 0022-1007 1540-9538 journal-article 1987 crrockefelleruni https://doi.org/10.1084/jem.166.2.583 2024-05-07T14:15:31Z We have studied a panel of DBA/2 T cell clones specific for sperm whale myoglobin (SpW Mb) for TCR (T cell receptor) beta chain gene expression by FACS analysis using the monoclonal antibodies F23.1 and KJ16 specific for the V beta 8 family of the TCR beta chain genes. Within any given specificity group, all the clones tested came from different mice. 10 of 11 I-Ed-restricted SpW Mb-specific T cell clones were F23.1+; 8 of these were also KJ16+. Only one of the three I-Ad-restricted clones tested was F23.1+; this clone was KJ16 negative. This study has demonstrated that I-Ed-restricted T cell clones from DBA/2 mice express members of the TCR V beta 8 family irrespective of the epitopes of SpW Mb recognized. These data suggest an apparent correlation between TCR V beta expression and MHC restriction. Article in Journal/Newspaper Sperm whale Rockefeller University Press Journal of Experimental Medicine 166 2 583 588 |
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Open Polar |
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Rockefeller University Press |
op_collection_id |
crrockefelleruni |
language |
English |
description |
We have studied a panel of DBA/2 T cell clones specific for sperm whale myoglobin (SpW Mb) for TCR (T cell receptor) beta chain gene expression by FACS analysis using the monoclonal antibodies F23.1 and KJ16 specific for the V beta 8 family of the TCR beta chain genes. Within any given specificity group, all the clones tested came from different mice. 10 of 11 I-Ed-restricted SpW Mb-specific T cell clones were F23.1+; 8 of these were also KJ16+. Only one of the three I-Ad-restricted clones tested was F23.1+; this clone was KJ16 negative. This study has demonstrated that I-Ed-restricted T cell clones from DBA/2 mice express members of the TCR V beta 8 family irrespective of the epitopes of SpW Mb recognized. These data suggest an apparent correlation between TCR V beta expression and MHC restriction. |
format |
Article in Journal/Newspaper |
author |
Morel, P A Livingstone, A M Fathman, C G |
spellingShingle |
Morel, P A Livingstone, A M Fathman, C G Correlation of T cell receptor V beta gene family with MHC restriction. |
author_facet |
Morel, P A Livingstone, A M Fathman, C G |
author_sort |
Morel, P A |
title |
Correlation of T cell receptor V beta gene family with MHC restriction. |
title_short |
Correlation of T cell receptor V beta gene family with MHC restriction. |
title_full |
Correlation of T cell receptor V beta gene family with MHC restriction. |
title_fullStr |
Correlation of T cell receptor V beta gene family with MHC restriction. |
title_full_unstemmed |
Correlation of T cell receptor V beta gene family with MHC restriction. |
title_sort |
correlation of t cell receptor v beta gene family with mhc restriction. |
publisher |
Rockefeller University Press |
publishDate |
1987 |
url |
http://dx.doi.org/10.1084/jem.166.2.583 https://rupress.org/jem/article-pdf/166/2/583/1668008/583.pdf |
genre |
Sperm whale |
genre_facet |
Sperm whale |
op_source |
The Journal of experimental medicine volume 166, issue 2, page 583-588 ISSN 0022-1007 1540-9538 |
op_doi |
https://doi.org/10.1084/jem.166.2.583 |
container_title |
Journal of Experimental Medicine |
container_volume |
166 |
container_issue |
2 |
container_start_page |
583 |
op_container_end_page |
588 |
_version_ |
1800738885541560320 |