Real-time diagnosis of sentinel lymph nodes involved to breast cancer based on pH sensing through lipid synthesis of those cells
Abstract Lipid synthesis is the recently found metabolism of cancer cells after their metastasis to lymph nodes (LNs). Carbonic acid is the main byproduct of the lipid metabolism in such cells which resulted in acidification of LN ambient. Hence, calibrated pH sensing could be a diagnostic method to...
Published in: | Bioscience Reports |
---|---|
Main Authors: | , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Portland Press Ltd.
2020
|
Subjects: | |
Online Access: | http://dx.doi.org/10.1042/bsr20200970 https://portlandpress.com/bioscirep/article-pdf/doi/10.1042/BSR20200970/883457/bsr-2020-0970.pdf |
id |
crportlandpress:10.1042/bsr20200970 |
---|---|
record_format |
openpolar |
spelling |
crportlandpress:10.1042/bsr20200970 2023-05-15T15:52:39+02:00 Real-time diagnosis of sentinel lymph nodes involved to breast cancer based on pH sensing through lipid synthesis of those cells Miripour, Zohreh S. Aghaee, Parisa Abbasvandi, Fereshteh Hoseinpour, Parisa Parniani, Mohammad Abdolahad, Mohammad 2020 http://dx.doi.org/10.1042/bsr20200970 https://portlandpress.com/bioscirep/article-pdf/doi/10.1042/BSR20200970/883457/bsr-2020-0970.pdf en eng Portland Press Ltd. https://creativecommons.org/licenses/by/4.0/ CC-BY Bioscience Reports volume 40, issue 6 ISSN 0144-8463 1573-4935 Cell Biology Molecular Biology Biochemistry Biophysics journal-article 2020 crportlandpress https://doi.org/10.1042/bsr20200970 2023-02-10T15:38:23Z Abstract Lipid synthesis is the recently found metabolism of cancer cells after their metastasis to lymph nodes (LNs). Carbonic acid is the main byproduct of the lipid metabolism in such cells which resulted in acidification of LN ambient. Hence, calibrated pH sensing could be a diagnostic method to find involved LNs. Here, we designed a simple pH sensing method by a syringe containing sterile PBS and embedded by litmus paper to intraoperatively check the pH of LN fluid. Injected phosphate buffer saline (PBS) would homogenize the LN fluid and litmus needle would detect the pH of the LN. We presented an experimental pathological calibration for the pH values in correlation with cancerous states of the LNs. This system named metabolism based metastatic lymph diagnoser (MMLD) could be a real-time noninvasive tool for precise and fast diagnosis of involved LNs. Article in Journal/Newspaper Carbonic acid Portland Press (via Crossref) Bioscience Reports 40 6 |
institution |
Open Polar |
collection |
Portland Press (via Crossref) |
op_collection_id |
crportlandpress |
language |
English |
topic |
Cell Biology Molecular Biology Biochemistry Biophysics |
spellingShingle |
Cell Biology Molecular Biology Biochemistry Biophysics Miripour, Zohreh S. Aghaee, Parisa Abbasvandi, Fereshteh Hoseinpour, Parisa Parniani, Mohammad Abdolahad, Mohammad Real-time diagnosis of sentinel lymph nodes involved to breast cancer based on pH sensing through lipid synthesis of those cells |
topic_facet |
Cell Biology Molecular Biology Biochemistry Biophysics |
description |
Abstract Lipid synthesis is the recently found metabolism of cancer cells after their metastasis to lymph nodes (LNs). Carbonic acid is the main byproduct of the lipid metabolism in such cells which resulted in acidification of LN ambient. Hence, calibrated pH sensing could be a diagnostic method to find involved LNs. Here, we designed a simple pH sensing method by a syringe containing sterile PBS and embedded by litmus paper to intraoperatively check the pH of LN fluid. Injected phosphate buffer saline (PBS) would homogenize the LN fluid and litmus needle would detect the pH of the LN. We presented an experimental pathological calibration for the pH values in correlation with cancerous states of the LNs. This system named metabolism based metastatic lymph diagnoser (MMLD) could be a real-time noninvasive tool for precise and fast diagnosis of involved LNs. |
format |
Article in Journal/Newspaper |
author |
Miripour, Zohreh S. Aghaee, Parisa Abbasvandi, Fereshteh Hoseinpour, Parisa Parniani, Mohammad Abdolahad, Mohammad |
author_facet |
Miripour, Zohreh S. Aghaee, Parisa Abbasvandi, Fereshteh Hoseinpour, Parisa Parniani, Mohammad Abdolahad, Mohammad |
author_sort |
Miripour, Zohreh S. |
title |
Real-time diagnosis of sentinel lymph nodes involved to breast cancer based on pH sensing through lipid synthesis of those cells |
title_short |
Real-time diagnosis of sentinel lymph nodes involved to breast cancer based on pH sensing through lipid synthesis of those cells |
title_full |
Real-time diagnosis of sentinel lymph nodes involved to breast cancer based on pH sensing through lipid synthesis of those cells |
title_fullStr |
Real-time diagnosis of sentinel lymph nodes involved to breast cancer based on pH sensing through lipid synthesis of those cells |
title_full_unstemmed |
Real-time diagnosis of sentinel lymph nodes involved to breast cancer based on pH sensing through lipid synthesis of those cells |
title_sort |
real-time diagnosis of sentinel lymph nodes involved to breast cancer based on ph sensing through lipid synthesis of those cells |
publisher |
Portland Press Ltd. |
publishDate |
2020 |
url |
http://dx.doi.org/10.1042/bsr20200970 https://portlandpress.com/bioscirep/article-pdf/doi/10.1042/BSR20200970/883457/bsr-2020-0970.pdf |
genre |
Carbonic acid |
genre_facet |
Carbonic acid |
op_source |
Bioscience Reports volume 40, issue 6 ISSN 0144-8463 1573-4935 |
op_rights |
https://creativecommons.org/licenses/by/4.0/ |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1042/bsr20200970 |
container_title |
Bioscience Reports |
container_volume |
40 |
container_issue |
6 |
_version_ |
1766387768521392128 |