Were inefficient mitochondrial haplogroups selected during migrations of modern humans? A test using modular kinetic analysis of coupling in mitochondria from cybrid cell lines

We introduce a general test of the bioenergetic importance of mtDNA (mitochondrial DNA) variants: modular kinetic analysis of oxidative phosphorylation in mitochondria from cybrid cells with constant nuclear DNA but different mtDNA. We have applied this test to the hypothesis [Ruiz-Pesini, Mishmar,...

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Published in:Biochemical Journal
Main Authors: Amo, Taku, Brand, Martin D.
Format: Article in Journal/Newspaper
Language:English
Published: Portland Press Ltd. 2007
Subjects:
Arctic
Online Access:http://dx.doi.org/10.1042/bj20061609
https://portlandpress.com/biochemj/article-pdf/404/2/345/648023/bj4040345.pdf
id crportlandpress:10.1042/bj20061609
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spelling crportlandpress:10.1042/bj20061609 2024-06-23T07:50:17+00:00 Were inefficient mitochondrial haplogroups selected during migrations of modern humans? A test using modular kinetic analysis of coupling in mitochondria from cybrid cell lines Amo, Taku Brand, Martin D. 2007 http://dx.doi.org/10.1042/bj20061609 https://portlandpress.com/biochemj/article-pdf/404/2/345/648023/bj4040345.pdf en eng Portland Press Ltd. Biochemical Journal volume 404, issue 2, page 345-351 ISSN 0264-6021 1470-8728 journal-article 2007 crportlandpress https://doi.org/10.1042/bj20061609 2024-05-30T08:21:56Z We introduce a general test of the bioenergetic importance of mtDNA (mitochondrial DNA) variants: modular kinetic analysis of oxidative phosphorylation in mitochondria from cybrid cells with constant nuclear DNA but different mtDNA. We have applied this test to the hypothesis [Ruiz-Pesini, Mishmar, Brandon, Procaccio and Wallace (2004) Science 303, 223–226] that particular mtDNA haplogroups (specific combinations of polymorphisms) that cause lowered coupling efficiency, leading to generation of less ATP and more heat, were positively selected during radiations of modern humans into colder climates. Contrary to the predictions of this hypothesis, mitochondria from Arctic haplogroups had similar or even greater coupling efficiency than mitochondria from tropical haplogroups. Article in Journal/Newspaper Arctic Portland Press Arctic Biochemical Journal 404 2 345 351
institution Open Polar
collection Portland Press
op_collection_id crportlandpress
language English
description We introduce a general test of the bioenergetic importance of mtDNA (mitochondrial DNA) variants: modular kinetic analysis of oxidative phosphorylation in mitochondria from cybrid cells with constant nuclear DNA but different mtDNA. We have applied this test to the hypothesis [Ruiz-Pesini, Mishmar, Brandon, Procaccio and Wallace (2004) Science 303, 223–226] that particular mtDNA haplogroups (specific combinations of polymorphisms) that cause lowered coupling efficiency, leading to generation of less ATP and more heat, were positively selected during radiations of modern humans into colder climates. Contrary to the predictions of this hypothesis, mitochondria from Arctic haplogroups had similar or even greater coupling efficiency than mitochondria from tropical haplogroups.
format Article in Journal/Newspaper
author Amo, Taku
Brand, Martin D.
spellingShingle Amo, Taku
Brand, Martin D.
Were inefficient mitochondrial haplogroups selected during migrations of modern humans? A test using modular kinetic analysis of coupling in mitochondria from cybrid cell lines
author_facet Amo, Taku
Brand, Martin D.
author_sort Amo, Taku
title Were inefficient mitochondrial haplogroups selected during migrations of modern humans? A test using modular kinetic analysis of coupling in mitochondria from cybrid cell lines
title_short Were inefficient mitochondrial haplogroups selected during migrations of modern humans? A test using modular kinetic analysis of coupling in mitochondria from cybrid cell lines
title_full Were inefficient mitochondrial haplogroups selected during migrations of modern humans? A test using modular kinetic analysis of coupling in mitochondria from cybrid cell lines
title_fullStr Were inefficient mitochondrial haplogroups selected during migrations of modern humans? A test using modular kinetic analysis of coupling in mitochondria from cybrid cell lines
title_full_unstemmed Were inefficient mitochondrial haplogroups selected during migrations of modern humans? A test using modular kinetic analysis of coupling in mitochondria from cybrid cell lines
title_sort were inefficient mitochondrial haplogroups selected during migrations of modern humans? a test using modular kinetic analysis of coupling in mitochondria from cybrid cell lines
publisher Portland Press Ltd.
publishDate 2007
url http://dx.doi.org/10.1042/bj20061609
https://portlandpress.com/biochemj/article-pdf/404/2/345/648023/bj4040345.pdf
geographic Arctic
geographic_facet Arctic
genre Arctic
genre_facet Arctic
op_source Biochemical Journal
volume 404, issue 2, page 345-351
ISSN 0264-6021 1470-8728
op_doi https://doi.org/10.1042/bj20061609
container_title Biochemical Journal
container_volume 404
container_issue 2
container_start_page 345
op_container_end_page 351
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