Global long-term trends and spatial cluster analysis of pancreatic cancer incidence and mortality over a 30-year period using the global burden of disease study 2019 data
Introduction Pancreatic cancer (PC) is one of the most fatal malignancies, and its incidence and mortality rates are growing annually throughout the world. In this research, we aimed to investigate the time trends and identify the spatial clusters of incidence and mortality on a global scale over th...
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crplos:10.1371/journal.pone.0288755 2024-09-30T14:35:53+00:00 Global long-term trends and spatial cluster analysis of pancreatic cancer incidence and mortality over a 30-year period using the global burden of disease study 2019 data Amini, Maedeh Azizmohammad Looha, Mehdi Rahimi Pordanjani, Sajjad Asadzadeh Aghdaei, Hamid Pourhoseingholi, Mohamad Amin De Camargo Cancela, Marianna 2023 http://dx.doi.org/10.1371/journal.pone.0288755 https://dx.plos.org/10.1371/journal.pone.0288755 en eng Public Library of Science (PLoS) http://creativecommons.org/licenses/by/4.0/ PLOS ONE volume 18, issue 7, page e0288755 ISSN 1932-6203 journal-article 2023 crplos https://doi.org/10.1371/journal.pone.0288755 2024-09-10T04:17:40Z Introduction Pancreatic cancer (PC) is one of the most fatal malignancies, and its incidence and mortality rates are growing annually throughout the world. In this research, we aimed to investigate the time trends and identify the spatial clusters of incidence and mortality on a global scale over the last 30 years, using the Global Burden of Disease (GBD) study 2019 data. Methods Age-standardized incidence and mortality data due to PC were extracted from the GBD study, which was carried out from 1990 to 2019. A Joinpoint regression analysis was utilized to examine trends in the incidence and mortality of PC over the past three decades. As such, spatial analyses were undertaken to detect the spatial distribution and clustering of the metrics globally. Results It was observed that both the incidence and mortality rates were higher in males than in females worldwide. The global mortality and incidence rates significantly increased by 0.8% per year over the time of follow-up period (p<0.05). By spatial cluster analysis for mortality, European and North African countries, as well as Greenland were explored as hot spots; while South African and Southeast Asian countries were explored as cold spots. Regarding incidence, hot spots were found in European countries, Southern America, and Greenland; whilst cold spots were determined in Southern Africa and Madagascar. Conclusions Collectively, the temporal trends disclosed a gradual rise in PC incidence and mortality rates over the period 1990–2019, reflecting the global health concern. We further found geographical variations in the patterns and identified high- and low-risk areas for incidence and mortality. These findings facilitate the design and implementation of more resource-efficient and geographically targeted treatments. Given the results of the current study, a practical approach to minimizing the future PC burden involves planned population-wide interventions, as well as primary prevention through healthier lifestyles. Article in Journal/Newspaper Greenland PLOS Greenland PLOS ONE 18 7 e0288755 |
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Introduction Pancreatic cancer (PC) is one of the most fatal malignancies, and its incidence and mortality rates are growing annually throughout the world. In this research, we aimed to investigate the time trends and identify the spatial clusters of incidence and mortality on a global scale over the last 30 years, using the Global Burden of Disease (GBD) study 2019 data. Methods Age-standardized incidence and mortality data due to PC were extracted from the GBD study, which was carried out from 1990 to 2019. A Joinpoint regression analysis was utilized to examine trends in the incidence and mortality of PC over the past three decades. As such, spatial analyses were undertaken to detect the spatial distribution and clustering of the metrics globally. Results It was observed that both the incidence and mortality rates were higher in males than in females worldwide. The global mortality and incidence rates significantly increased by 0.8% per year over the time of follow-up period (p<0.05). By spatial cluster analysis for mortality, European and North African countries, as well as Greenland were explored as hot spots; while South African and Southeast Asian countries were explored as cold spots. Regarding incidence, hot spots were found in European countries, Southern America, and Greenland; whilst cold spots were determined in Southern Africa and Madagascar. Conclusions Collectively, the temporal trends disclosed a gradual rise in PC incidence and mortality rates over the period 1990–2019, reflecting the global health concern. We further found geographical variations in the patterns and identified high- and low-risk areas for incidence and mortality. These findings facilitate the design and implementation of more resource-efficient and geographically targeted treatments. Given the results of the current study, a practical approach to minimizing the future PC burden involves planned population-wide interventions, as well as primary prevention through healthier lifestyles. |
author2 |
De Camargo Cancela, Marianna |
format |
Article in Journal/Newspaper |
author |
Amini, Maedeh Azizmohammad Looha, Mehdi Rahimi Pordanjani, Sajjad Asadzadeh Aghdaei, Hamid Pourhoseingholi, Mohamad Amin |
spellingShingle |
Amini, Maedeh Azizmohammad Looha, Mehdi Rahimi Pordanjani, Sajjad Asadzadeh Aghdaei, Hamid Pourhoseingholi, Mohamad Amin Global long-term trends and spatial cluster analysis of pancreatic cancer incidence and mortality over a 30-year period using the global burden of disease study 2019 data |
author_facet |
Amini, Maedeh Azizmohammad Looha, Mehdi Rahimi Pordanjani, Sajjad Asadzadeh Aghdaei, Hamid Pourhoseingholi, Mohamad Amin |
author_sort |
Amini, Maedeh |
title |
Global long-term trends and spatial cluster analysis of pancreatic cancer incidence and mortality over a 30-year period using the global burden of disease study 2019 data |
title_short |
Global long-term trends and spatial cluster analysis of pancreatic cancer incidence and mortality over a 30-year period using the global burden of disease study 2019 data |
title_full |
Global long-term trends and spatial cluster analysis of pancreatic cancer incidence and mortality over a 30-year period using the global burden of disease study 2019 data |
title_fullStr |
Global long-term trends and spatial cluster analysis of pancreatic cancer incidence and mortality over a 30-year period using the global burden of disease study 2019 data |
title_full_unstemmed |
Global long-term trends and spatial cluster analysis of pancreatic cancer incidence and mortality over a 30-year period using the global burden of disease study 2019 data |
title_sort |
global long-term trends and spatial cluster analysis of pancreatic cancer incidence and mortality over a 30-year period using the global burden of disease study 2019 data |
publisher |
Public Library of Science (PLoS) |
publishDate |
2023 |
url |
http://dx.doi.org/10.1371/journal.pone.0288755 https://dx.plos.org/10.1371/journal.pone.0288755 |
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Greenland |
geographic_facet |
Greenland |
genre |
Greenland |
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Greenland |
op_source |
PLOS ONE volume 18, issue 7, page e0288755 ISSN 1932-6203 |
op_rights |
http://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.1371/journal.pone.0288755 |
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PLOS ONE |
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