Elevated plasma phospholipid n-3 docosapentaenoic acid concentrations during hibernation
Factors for initiating hibernation are unknown, but the condition shares some metabolic similarities with consciousness/sleep, which has been associated with n-3 fatty acids in humans. We investigated plasma phospholipid fatty acid profiles during hibernation and summer in free-ranging brown bears (...
Published in: | PLOS ONE |
---|---|
Main Authors: | , , , , , , , , |
Other Authors: | , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Public Library of Science (PLoS)
2023
|
Subjects: | |
Online Access: | http://dx.doi.org/10.1371/journal.pone.0285782 https://dx.plos.org/10.1371/journal.pone.0285782 |
id |
crplos:10.1371/journal.pone.0285782 |
---|---|
record_format |
openpolar |
spelling |
crplos:10.1371/journal.pone.0285782 2024-09-30T14:45:37+00:00 Elevated plasma phospholipid n-3 docosapentaenoic acid concentrations during hibernation Strandvik, Birgitta Qureshi, Abdul Rashid Painer, Johanna Backman-Johansson, Carolina Engvall, Martin Fröbert, Ole Kindberg, Jonas Stenvinkel, Peter Giroud, Sylvain Sakakibara, Manabu Hjärt-Lungfonden Stiftelsen Stig och Gunborg Westman Stockholms Läns Landsting Center for Innovative Medicine Veterinärmedizinische Universität Wien Austrian Science Fund 2023 http://dx.doi.org/10.1371/journal.pone.0285782 https://dx.plos.org/10.1371/journal.pone.0285782 en eng Public Library of Science (PLoS) http://creativecommons.org/licenses/by/4.0/ PLOS ONE volume 18, issue 6, page e0285782 ISSN 1932-6203 journal-article 2023 crplos https://doi.org/10.1371/journal.pone.0285782 2024-09-03T04:15:11Z Factors for initiating hibernation are unknown, but the condition shares some metabolic similarities with consciousness/sleep, which has been associated with n-3 fatty acids in humans. We investigated plasma phospholipid fatty acid profiles during hibernation and summer in free-ranging brown bears ( Ursus arctos ) and in captive garden dormice ( Eliomys quercinus ) contrasting in their hibernation patterns. The dormice received three different dietary fatty acid concentrations of linoleic acid (LA) (19%, 36% and 53%), with correspondingly decreased alpha-linolenic acid (ALA) (32%, 17% and 1.4%). Saturated and monounsaturated fatty acids showed small differences between summer and hibernation in both species. The dormice diet influenced n-6 fatty acids and eicosapentaenoic acid (EPA) concentrations in plasma phospholipids. Consistent differences between summer and hibernation in bears and dormice were decreased ALA and EPA and marked increase of n-3 docosapentaenoic acid and a minor increase of docosahexaenoic acid in parallel with several hundred percent increase of the activity index of elongase ELOVL2 transforming C20-22 fatty acids. The highest LA supply was unexpectantly associated with the highest transformation of the n-3 fatty acids. Similar fatty acid patterns in two contrasting hibernating species indicates a link to the hibernation phenotype and requires further studies in relation to consciousness and metabolism. Article in Journal/Newspaper Ursus arctos PLOS PLOS ONE 18 6 e0285782 |
institution |
Open Polar |
collection |
PLOS |
op_collection_id |
crplos |
language |
English |
description |
Factors for initiating hibernation are unknown, but the condition shares some metabolic similarities with consciousness/sleep, which has been associated with n-3 fatty acids in humans. We investigated plasma phospholipid fatty acid profiles during hibernation and summer in free-ranging brown bears ( Ursus arctos ) and in captive garden dormice ( Eliomys quercinus ) contrasting in their hibernation patterns. The dormice received three different dietary fatty acid concentrations of linoleic acid (LA) (19%, 36% and 53%), with correspondingly decreased alpha-linolenic acid (ALA) (32%, 17% and 1.4%). Saturated and monounsaturated fatty acids showed small differences between summer and hibernation in both species. The dormice diet influenced n-6 fatty acids and eicosapentaenoic acid (EPA) concentrations in plasma phospholipids. Consistent differences between summer and hibernation in bears and dormice were decreased ALA and EPA and marked increase of n-3 docosapentaenoic acid and a minor increase of docosahexaenoic acid in parallel with several hundred percent increase of the activity index of elongase ELOVL2 transforming C20-22 fatty acids. The highest LA supply was unexpectantly associated with the highest transformation of the n-3 fatty acids. Similar fatty acid patterns in two contrasting hibernating species indicates a link to the hibernation phenotype and requires further studies in relation to consciousness and metabolism. |
author2 |
Sakakibara, Manabu Hjärt-Lungfonden Stiftelsen Stig och Gunborg Westman Stockholms Läns Landsting Center for Innovative Medicine Veterinärmedizinische Universität Wien Austrian Science Fund |
format |
Article in Journal/Newspaper |
author |
Strandvik, Birgitta Qureshi, Abdul Rashid Painer, Johanna Backman-Johansson, Carolina Engvall, Martin Fröbert, Ole Kindberg, Jonas Stenvinkel, Peter Giroud, Sylvain |
spellingShingle |
Strandvik, Birgitta Qureshi, Abdul Rashid Painer, Johanna Backman-Johansson, Carolina Engvall, Martin Fröbert, Ole Kindberg, Jonas Stenvinkel, Peter Giroud, Sylvain Elevated plasma phospholipid n-3 docosapentaenoic acid concentrations during hibernation |
author_facet |
Strandvik, Birgitta Qureshi, Abdul Rashid Painer, Johanna Backman-Johansson, Carolina Engvall, Martin Fröbert, Ole Kindberg, Jonas Stenvinkel, Peter Giroud, Sylvain |
author_sort |
Strandvik, Birgitta |
title |
Elevated plasma phospholipid n-3 docosapentaenoic acid concentrations during hibernation |
title_short |
Elevated plasma phospholipid n-3 docosapentaenoic acid concentrations during hibernation |
title_full |
Elevated plasma phospholipid n-3 docosapentaenoic acid concentrations during hibernation |
title_fullStr |
Elevated plasma phospholipid n-3 docosapentaenoic acid concentrations during hibernation |
title_full_unstemmed |
Elevated plasma phospholipid n-3 docosapentaenoic acid concentrations during hibernation |
title_sort |
elevated plasma phospholipid n-3 docosapentaenoic acid concentrations during hibernation |
publisher |
Public Library of Science (PLoS) |
publishDate |
2023 |
url |
http://dx.doi.org/10.1371/journal.pone.0285782 https://dx.plos.org/10.1371/journal.pone.0285782 |
genre |
Ursus arctos |
genre_facet |
Ursus arctos |
op_source |
PLOS ONE volume 18, issue 6, page e0285782 ISSN 1932-6203 |
op_rights |
http://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.1371/journal.pone.0285782 |
container_title |
PLOS ONE |
container_volume |
18 |
container_issue |
6 |
container_start_page |
e0285782 |
_version_ |
1811646160020963328 |