Cannabis use in pregnancy and maternal and infant outcomes: A Canadian cross-jurisdictional population-based cohort study
Background With the recent legalization of cannabis in Canada, there is an urgent need to understand the effect of cannabis use in pregnancy. Our population-based study investigated the effects of prenatal cannabis use on maternal and newborn outcomes, and modification by infant sex. Methods The coh...
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crplos:10.1371/journal.pone.0276824 2024-05-19T07:44:19+00:00 Cannabis use in pregnancy and maternal and infant outcomes: A Canadian cross-jurisdictional population-based cohort study Luke, Sabrina Hobbs, Amy J. Smith, Michaela Riddell, Catherine Murphy, Phil Agborsangaya, Calypse Cantin, Christina Fahey, John Der, Kenny Pederson, Ann Nelson, Chantal Ehrlich, Samantha Frances Public Health Agency of Canada 2022 http://dx.doi.org/10.1371/journal.pone.0276824 https://dx.plos.org/10.1371/journal.pone.0276824 en eng Public Library of Science (PLoS) http://creativecommons.org/licenses/by/4.0/ PLOS ONE volume 17, issue 11, page e0276824 ISSN 1932-6203 journal-article 2022 crplos https://doi.org/10.1371/journal.pone.0276824 2024-05-01T07:03:08Z Background With the recent legalization of cannabis in Canada, there is an urgent need to understand the effect of cannabis use in pregnancy. Our population-based study investigated the effects of prenatal cannabis use on maternal and newborn outcomes, and modification by infant sex. Methods The cohort included 1,280,447 singleton births from the British Columbia Perinatal Data Registry, the Better Outcomes Registry & Network Ontario, and the Perinatal Program Newfoundland Labrador from April 1st, 2012 to March 31st, 2019. Logistic regression determined the associations between prenatal cannabis use and low birth weight, small-for-gestational age, large-for-gestational age, spontaneous and medically indicated preterm birth, very preterm birth, stillbirth, major congenital anomalies, caesarean section, gestational diabetes and gestational hypertension. Models were adjusted for other substance use, socio-demographic and-economic characteristics, co-morbidities. Interaction terms were included to investigate modification by infant sex. Results The prevalence of cannabis use in our cohort was approximately 2%. Prenatal cannabis use is associated with increased risks of spontaneous and medically indicated preterm birth (1.80[1.68–1.93] and 1.94[1.77–2.12], respectively), very preterm birth (1.73[1.48–2.02]), low birth weight (1.90[1.79–2.03]), small-for-gestational age (1.21[1.16–1.27]) and large-for-gestational age (1.06[1.01–1.12]), any major congenital anomaly (1.71[1.49–1.97]), caesarean section (1.13[1.09–1.17]), and gestational diabetes (1.32[1.23–1.42]). No association was found for stillbirth or gestational hypertension. Only small-for-gestational age (p = 0.03) and spontaneous preterm birth (p = 0.04) showed evidence of modification by infant sex. Conclusions Prenatal cannabis use increases the likelihood of preterm birth, low birth weight, small-for-gestational age and major congenital anomalies with prenatally exposed female infants showing evidence of increased susceptibility. Additional measures are ... Article in Journal/Newspaper Newfoundland PLOS PLOS ONE 17 11 e0276824 |
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Background With the recent legalization of cannabis in Canada, there is an urgent need to understand the effect of cannabis use in pregnancy. Our population-based study investigated the effects of prenatal cannabis use on maternal and newborn outcomes, and modification by infant sex. Methods The cohort included 1,280,447 singleton births from the British Columbia Perinatal Data Registry, the Better Outcomes Registry & Network Ontario, and the Perinatal Program Newfoundland Labrador from April 1st, 2012 to March 31st, 2019. Logistic regression determined the associations between prenatal cannabis use and low birth weight, small-for-gestational age, large-for-gestational age, spontaneous and medically indicated preterm birth, very preterm birth, stillbirth, major congenital anomalies, caesarean section, gestational diabetes and gestational hypertension. Models were adjusted for other substance use, socio-demographic and-economic characteristics, co-morbidities. Interaction terms were included to investigate modification by infant sex. Results The prevalence of cannabis use in our cohort was approximately 2%. Prenatal cannabis use is associated with increased risks of spontaneous and medically indicated preterm birth (1.80[1.68–1.93] and 1.94[1.77–2.12], respectively), very preterm birth (1.73[1.48–2.02]), low birth weight (1.90[1.79–2.03]), small-for-gestational age (1.21[1.16–1.27]) and large-for-gestational age (1.06[1.01–1.12]), any major congenital anomaly (1.71[1.49–1.97]), caesarean section (1.13[1.09–1.17]), and gestational diabetes (1.32[1.23–1.42]). No association was found for stillbirth or gestational hypertension. Only small-for-gestational age (p = 0.03) and spontaneous preterm birth (p = 0.04) showed evidence of modification by infant sex. Conclusions Prenatal cannabis use increases the likelihood of preterm birth, low birth weight, small-for-gestational age and major congenital anomalies with prenatally exposed female infants showing evidence of increased susceptibility. Additional measures are ... |
author2 |
Ehrlich, Samantha Frances Public Health Agency of Canada |
format |
Article in Journal/Newspaper |
author |
Luke, Sabrina Hobbs, Amy J. Smith, Michaela Riddell, Catherine Murphy, Phil Agborsangaya, Calypse Cantin, Christina Fahey, John Der, Kenny Pederson, Ann Nelson, Chantal |
spellingShingle |
Luke, Sabrina Hobbs, Amy J. Smith, Michaela Riddell, Catherine Murphy, Phil Agborsangaya, Calypse Cantin, Christina Fahey, John Der, Kenny Pederson, Ann Nelson, Chantal Cannabis use in pregnancy and maternal and infant outcomes: A Canadian cross-jurisdictional population-based cohort study |
author_facet |
Luke, Sabrina Hobbs, Amy J. Smith, Michaela Riddell, Catherine Murphy, Phil Agborsangaya, Calypse Cantin, Christina Fahey, John Der, Kenny Pederson, Ann Nelson, Chantal |
author_sort |
Luke, Sabrina |
title |
Cannabis use in pregnancy and maternal and infant outcomes: A Canadian cross-jurisdictional population-based cohort study |
title_short |
Cannabis use in pregnancy and maternal and infant outcomes: A Canadian cross-jurisdictional population-based cohort study |
title_full |
Cannabis use in pregnancy and maternal and infant outcomes: A Canadian cross-jurisdictional population-based cohort study |
title_fullStr |
Cannabis use in pregnancy and maternal and infant outcomes: A Canadian cross-jurisdictional population-based cohort study |
title_full_unstemmed |
Cannabis use in pregnancy and maternal and infant outcomes: A Canadian cross-jurisdictional population-based cohort study |
title_sort |
cannabis use in pregnancy and maternal and infant outcomes: a canadian cross-jurisdictional population-based cohort study |
publisher |
Public Library of Science (PLoS) |
publishDate |
2022 |
url |
http://dx.doi.org/10.1371/journal.pone.0276824 https://dx.plos.org/10.1371/journal.pone.0276824 |
genre |
Newfoundland |
genre_facet |
Newfoundland |
op_source |
PLOS ONE volume 17, issue 11, page e0276824 ISSN 1932-6203 |
op_rights |
http://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.1371/journal.pone.0276824 |
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PLOS ONE |
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17 |
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11 |
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