Accuracy and reliability of focused echocardiography in patients with Chagas disease from endemic areas: SaMi-Trop cohort study
Background Chagas disease remains a major cause of cardiovascular death in endemic areas. Focused echocardiography (FoCUS) is a point-of-care means of assessing cardiac function which can be useful for the diagnosis of cardiac involvement. Objective This study aims evaluating the characteristics of...
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crplos:10.1371/journal.pone.0258767 2024-05-19T07:48:01+00:00 Accuracy and reliability of focused echocardiography in patients with Chagas disease from endemic areas: SaMi-Trop cohort study Martins Barros, Isabella Morais Barros, Marcio Vinicius L. Almeida Martins, Larissa Natany Ribeiro, Antonio Luiz P. de Camargo, Raul Silva Simões Oliveira, Claudia Di Lorenzo Ferreira, Ariela Mota de Oliveira, Lea Campos Bierrenbach, Ana Luiza Haikal, Desireé Sant´Ana Sabino, Ester Cerdeira Cardoso, Clareci S. Nunes, Maria Carmo Pereira Morris, Daniel A. National Institutes of Health National Council for Scientific and Technological Development National Council for Scientific and Technological Development CAPES Foundation, Ministry of Brazil National Council for Scientific and Technological Development Minas Gerais Research Foundation 2021 http://dx.doi.org/10.1371/journal.pone.0258767 https://dx.plos.org/10.1371/journal.pone.0258767 en eng Public Library of Science (PLoS) http://creativecommons.org/licenses/by/4.0/ PLOS ONE volume 16, issue 11, page e0258767 ISSN 1932-6203 journal-article 2021 crplos https://doi.org/10.1371/journal.pone.0258767 2024-05-01T07:03:20Z Background Chagas disease remains a major cause of cardiovascular death in endemic areas. Focused echocardiography (FoCUS) is a point-of-care means of assessing cardiac function which can be useful for the diagnosis of cardiac involvement. Objective This study aims evaluating the characteristics of validity and reliability of FoCUS applied on Chagas disease patients. Methods Patients with Chagas disease coming from an endemic area were selected from a large cohort (SaMi-Trop). A simplified echocardiogram with only three images was extracted from the conventional echocardiogram performed in this cohort. The images were evaluated by an observer who was blinded to the clinical and echocardiographic data, to determine the accuracy and reliability of FoCUS for cardiac assessment. The analysis constituted of 5 prespecified variables, dichotomized in absence or presence: left ventricular (LV) size and systolic function, right ventricular (RV) size and systolic function, and LV aneurysm. Results We included 725 patients with a mean age of 63.4 ± 12.3 years, 483 (67%) female. Abnormal electrocardiogram was observed in 81.5% of the patients. Left and right ventricular dysfunctions were found in 103 (14%) and 49 (7%) of the patients, respectively. Sensitivity, specificity, positive predictive value and negative predictive value were 84%, 94%, 70% and 97% for LV enlargement and 81%, 93%, 68% and 97% for LV systolic dysfunction, respectively, and 46%, 99%, 60% and 98% for RV dilatation, and 37%, 100%, 100% and 96% for RV dysfunction, respectively. Inter and intraobserver agreement were 61% and 87% for LV enlargement and 63% and 92% for LV dysfunction, respectively, and 50% and 49% for RV size and 46% and 79% for RV dysfunction, respectively. LV apical aneurysm was found in 45 patients (6.2%) with the lowest sensitivity of FoCUS study (11%; 95% CI 2–28%). Conclusions FoCUS showed satisfactory values of validity and reliability for assessment of cardiac chambers in patients with Chagas disease, except for apical aneurysm. This ... Article in Journal/Newspaper sami PLOS PLOS ONE 16 11 e0258767 |
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Background Chagas disease remains a major cause of cardiovascular death in endemic areas. Focused echocardiography (FoCUS) is a point-of-care means of assessing cardiac function which can be useful for the diagnosis of cardiac involvement. Objective This study aims evaluating the characteristics of validity and reliability of FoCUS applied on Chagas disease patients. Methods Patients with Chagas disease coming from an endemic area were selected from a large cohort (SaMi-Trop). A simplified echocardiogram with only three images was extracted from the conventional echocardiogram performed in this cohort. The images were evaluated by an observer who was blinded to the clinical and echocardiographic data, to determine the accuracy and reliability of FoCUS for cardiac assessment. The analysis constituted of 5 prespecified variables, dichotomized in absence or presence: left ventricular (LV) size and systolic function, right ventricular (RV) size and systolic function, and LV aneurysm. Results We included 725 patients with a mean age of 63.4 ± 12.3 years, 483 (67%) female. Abnormal electrocardiogram was observed in 81.5% of the patients. Left and right ventricular dysfunctions were found in 103 (14%) and 49 (7%) of the patients, respectively. Sensitivity, specificity, positive predictive value and negative predictive value were 84%, 94%, 70% and 97% for LV enlargement and 81%, 93%, 68% and 97% for LV systolic dysfunction, respectively, and 46%, 99%, 60% and 98% for RV dilatation, and 37%, 100%, 100% and 96% for RV dysfunction, respectively. Inter and intraobserver agreement were 61% and 87% for LV enlargement and 63% and 92% for LV dysfunction, respectively, and 50% and 49% for RV size and 46% and 79% for RV dysfunction, respectively. LV apical aneurysm was found in 45 patients (6.2%) with the lowest sensitivity of FoCUS study (11%; 95% CI 2–28%). Conclusions FoCUS showed satisfactory values of validity and reliability for assessment of cardiac chambers in patients with Chagas disease, except for apical aneurysm. This ... |
author2 |
Morris, Daniel A. National Institutes of Health National Council for Scientific and Technological Development National Council for Scientific and Technological Development CAPES Foundation, Ministry of Brazil National Council for Scientific and Technological Development Minas Gerais Research Foundation |
format |
Article in Journal/Newspaper |
author |
Martins Barros, Isabella Morais Barros, Marcio Vinicius L. Almeida Martins, Larissa Natany Ribeiro, Antonio Luiz P. de Camargo, Raul Silva Simões Oliveira, Claudia Di Lorenzo Ferreira, Ariela Mota de Oliveira, Lea Campos Bierrenbach, Ana Luiza Haikal, Desireé Sant´Ana Sabino, Ester Cerdeira Cardoso, Clareci S. Nunes, Maria Carmo Pereira |
spellingShingle |
Martins Barros, Isabella Morais Barros, Marcio Vinicius L. Almeida Martins, Larissa Natany Ribeiro, Antonio Luiz P. de Camargo, Raul Silva Simões Oliveira, Claudia Di Lorenzo Ferreira, Ariela Mota de Oliveira, Lea Campos Bierrenbach, Ana Luiza Haikal, Desireé Sant´Ana Sabino, Ester Cerdeira Cardoso, Clareci S. Nunes, Maria Carmo Pereira Accuracy and reliability of focused echocardiography in patients with Chagas disease from endemic areas: SaMi-Trop cohort study |
author_facet |
Martins Barros, Isabella Morais Barros, Marcio Vinicius L. Almeida Martins, Larissa Natany Ribeiro, Antonio Luiz P. de Camargo, Raul Silva Simões Oliveira, Claudia Di Lorenzo Ferreira, Ariela Mota de Oliveira, Lea Campos Bierrenbach, Ana Luiza Haikal, Desireé Sant´Ana Sabino, Ester Cerdeira Cardoso, Clareci S. Nunes, Maria Carmo Pereira |
author_sort |
Martins Barros, Isabella Morais |
title |
Accuracy and reliability of focused echocardiography in patients with Chagas disease from endemic areas: SaMi-Trop cohort study |
title_short |
Accuracy and reliability of focused echocardiography in patients with Chagas disease from endemic areas: SaMi-Trop cohort study |
title_full |
Accuracy and reliability of focused echocardiography in patients with Chagas disease from endemic areas: SaMi-Trop cohort study |
title_fullStr |
Accuracy and reliability of focused echocardiography in patients with Chagas disease from endemic areas: SaMi-Trop cohort study |
title_full_unstemmed |
Accuracy and reliability of focused echocardiography in patients with Chagas disease from endemic areas: SaMi-Trop cohort study |
title_sort |
accuracy and reliability of focused echocardiography in patients with chagas disease from endemic areas: sami-trop cohort study |
publisher |
Public Library of Science (PLoS) |
publishDate |
2021 |
url |
http://dx.doi.org/10.1371/journal.pone.0258767 https://dx.plos.org/10.1371/journal.pone.0258767 |
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sami |
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sami |
op_source |
PLOS ONE volume 16, issue 11, page e0258767 ISSN 1932-6203 |
op_rights |
http://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.1371/journal.pone.0258767 |
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PLOS ONE |
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16 |
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11 |
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e0258767 |
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