Associations of nerve conduction parameters and OCT angiography results in adolescents with type 1 diabetes
Aim To evaluate dependence of abnormalities in peripheral nerves and retina in children with type 1 diabetes (T1D) using optical coherence tomography angiography (OCTA) and nerve conduction studies (NCS). Material and methods 50 adolescents with T1D without any signs and symptoms of diabetic retinop...
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crplos:10.1371/journal.pone.0252588 2024-05-19T07:39:27+00:00 Associations of nerve conduction parameters and OCT angiography results in adolescents with type 1 diabetes Wysocka-Mincewicz, Marta Gołębiewska, Joanna Baszyńska-Wilk, Marta Olechowski, Andrzej Byczyńska, Aleksandra Mazur, Maria Nowacka-Gotowiec, Monika Malik, Rayaz A. 2021 http://dx.doi.org/10.1371/journal.pone.0252588 https://dx.plos.org/10.1371/journal.pone.0252588 en eng Public Library of Science (PLoS) http://creativecommons.org/licenses/by/4.0/ PLOS ONE volume 16, issue 6, page e0252588 ISSN 1932-6203 journal-article 2021 crplos https://doi.org/10.1371/journal.pone.0252588 2024-05-01T07:04:12Z Aim To evaluate dependence of abnormalities in peripheral nerves and retina in children with type 1 diabetes (T1D) using optical coherence tomography angiography (OCTA) and nerve conduction studies (NCS). Material and methods 50 adolescents with T1D without any signs and symptoms of diabetic retinopathy and neuropathy (mean age 16.92±1.6 years, diabetes duration 6.88 ±4.34years) were included. In OCTA capillary plexuses superficial (SCP) and deep (DCP) vessel density: whole, foveal and parafoveal, ganglion cell complex (GCC), loss volume focal (FLV) and global loss volume (GLV) were analyzed in relation to NCS parameters (motor nerves median and tibial potential amplitude (CMAP), velocity (CV), distal latency (DML) and F wave and sensory nerves median and sural potential amplitude (SNAP), CV and distal latency (DSL). Results We detected the correlations between median sensory SNAP and GCC (r = -0.3, p <0.04), motor nerves tibial DML and CV and FLV (respectively r = -0.53, p<0.001, and r = -0.34, p<0.05), and median DML and GLV (r = 0.47, p<0.001). Vessel densities were related to changes in motor nerves tibial velocity (whole SCP r = 0.43, p <0.01, parafoveal SCP r = 0.41, p <0.01), CMAP (parafoveal SCP r = -0.35, p<0.03), median DML (whole DC r = 0.36, p<0.03, foveal DCP r = 0.37, p<0.02) and in sensory median SNAP (whole SCP r = -0.31, p<0.05). Conclusions In adolescents with T1D without diabetic neuropathy and retinopathy we detected associations between NCS and OCT and OCTA parameters, regarding decreased GCC and density of superficial and deep vessel plexuses in relation to DML and CV and amplitudes of sensory and motor potential. Article in Journal/Newspaper DML PLOS PLOS ONE 16 6 e0252588 |
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Aim To evaluate dependence of abnormalities in peripheral nerves and retina in children with type 1 diabetes (T1D) using optical coherence tomography angiography (OCTA) and nerve conduction studies (NCS). Material and methods 50 adolescents with T1D without any signs and symptoms of diabetic retinopathy and neuropathy (mean age 16.92±1.6 years, diabetes duration 6.88 ±4.34years) were included. In OCTA capillary plexuses superficial (SCP) and deep (DCP) vessel density: whole, foveal and parafoveal, ganglion cell complex (GCC), loss volume focal (FLV) and global loss volume (GLV) were analyzed in relation to NCS parameters (motor nerves median and tibial potential amplitude (CMAP), velocity (CV), distal latency (DML) and F wave and sensory nerves median and sural potential amplitude (SNAP), CV and distal latency (DSL). Results We detected the correlations between median sensory SNAP and GCC (r = -0.3, p <0.04), motor nerves tibial DML and CV and FLV (respectively r = -0.53, p<0.001, and r = -0.34, p<0.05), and median DML and GLV (r = 0.47, p<0.001). Vessel densities were related to changes in motor nerves tibial velocity (whole SCP r = 0.43, p <0.01, parafoveal SCP r = 0.41, p <0.01), CMAP (parafoveal SCP r = -0.35, p<0.03), median DML (whole DC r = 0.36, p<0.03, foveal DCP r = 0.37, p<0.02) and in sensory median SNAP (whole SCP r = -0.31, p<0.05). Conclusions In adolescents with T1D without diabetic neuropathy and retinopathy we detected associations between NCS and OCT and OCTA parameters, regarding decreased GCC and density of superficial and deep vessel plexuses in relation to DML and CV and amplitudes of sensory and motor potential. |
author2 |
Malik, Rayaz A. |
format |
Article in Journal/Newspaper |
author |
Wysocka-Mincewicz, Marta Gołębiewska, Joanna Baszyńska-Wilk, Marta Olechowski, Andrzej Byczyńska, Aleksandra Mazur, Maria Nowacka-Gotowiec, Monika |
spellingShingle |
Wysocka-Mincewicz, Marta Gołębiewska, Joanna Baszyńska-Wilk, Marta Olechowski, Andrzej Byczyńska, Aleksandra Mazur, Maria Nowacka-Gotowiec, Monika Associations of nerve conduction parameters and OCT angiography results in adolescents with type 1 diabetes |
author_facet |
Wysocka-Mincewicz, Marta Gołębiewska, Joanna Baszyńska-Wilk, Marta Olechowski, Andrzej Byczyńska, Aleksandra Mazur, Maria Nowacka-Gotowiec, Monika |
author_sort |
Wysocka-Mincewicz, Marta |
title |
Associations of nerve conduction parameters and OCT angiography results in adolescents with type 1 diabetes |
title_short |
Associations of nerve conduction parameters and OCT angiography results in adolescents with type 1 diabetes |
title_full |
Associations of nerve conduction parameters and OCT angiography results in adolescents with type 1 diabetes |
title_fullStr |
Associations of nerve conduction parameters and OCT angiography results in adolescents with type 1 diabetes |
title_full_unstemmed |
Associations of nerve conduction parameters and OCT angiography results in adolescents with type 1 diabetes |
title_sort |
associations of nerve conduction parameters and oct angiography results in adolescents with type 1 diabetes |
publisher |
Public Library of Science (PLoS) |
publishDate |
2021 |
url |
http://dx.doi.org/10.1371/journal.pone.0252588 https://dx.plos.org/10.1371/journal.pone.0252588 |
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DML |
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DML |
op_source |
PLOS ONE volume 16, issue 6, page e0252588 ISSN 1932-6203 |
op_rights |
http://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.1371/journal.pone.0252588 |
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PLOS ONE |
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16 |
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6 |
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e0252588 |
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