The association between water hardness and xerosis—Results from the Danish Blood Donor Study
Background The pathophysiology of xerosis depends on extrinsic and intrinsic exposures. Residential hard water may constitute such an exposure. Objectives To estimate the prevalence of xerosis and to compare water hardness exposure in blood donors with and without xerosis. Methods In this retrospect...
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crplos:10.1371/journal.pone.0252462 2024-05-19T07:41:23+00:00 The association between water hardness and xerosis—Results from the Danish Blood Donor Study Henning, Mattias A. S. Ibler, Kristina S. Ullum, Henrik Erikstrup, Christian Bruun, Mie T. Burgdorf, Kristoffer S. Dinh, Khoa M. Rigas, Andreas Thørner, Lise W. Pedersen, Ole B. Jemec, Gregor B. Kaliyadan, Feroze LEO Fondet 2021 http://dx.doi.org/10.1371/journal.pone.0252462 https://dx.plos.org/10.1371/journal.pone.0252462 en eng Public Library of Science (PLoS) http://creativecommons.org/licenses/by/4.0/ PLOS ONE volume 16, issue 6, page e0252462 ISSN 1932-6203 journal-article 2021 crplos https://doi.org/10.1371/journal.pone.0252462 2024-05-01T06:56:27Z Background The pathophysiology of xerosis depends on extrinsic and intrinsic exposures. Residential hard water may constitute such an exposure. Objectives To estimate the prevalence of xerosis and to compare water hardness exposure in blood donors with and without xerosis. Methods In this retrospective cohort study in 2018–2019, blood donors with self-reported moderately or severely dry skin were compared to blood donors without dry skin. Blood donors with ichthyosis, lichen planus and psoriasis were excluded. Water hardness data was collected from the Geology Survey of Denmark and Greenland. Results Overall, 4,748 of 30,721 (15.5%; 95% confidence interval 15.1–15.9%) blood donors had xerosis. After excluding blood donors with ichthyosis, lichen planus and psoriasis, 4,416 blood donors (2,559 females; median age 38.4 years [interquartile range 28.0–49.8]; 700 smokers) remained in this study. Water softer than 12–24 degrees Deutsche härte was associated with decreased probability of xerosis (odds ratio 0.83; 95% confidence interval 0.74–0.94) and water harder than 12–24 degrees Deutsche härte was associated with increased probability of xerosis (odds ratio 1.22; 95% confidence interval 1.03–1.45). The association between water hardness and xerosis remained significant after excluding blood donors with dermatitis. Conclusions Water hardness is associated with xerosis independent of other dermatoses. Article in Journal/Newspaper Greenland PLOS PLOS ONE 16 6 e0252462 |
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Background The pathophysiology of xerosis depends on extrinsic and intrinsic exposures. Residential hard water may constitute such an exposure. Objectives To estimate the prevalence of xerosis and to compare water hardness exposure in blood donors with and without xerosis. Methods In this retrospective cohort study in 2018–2019, blood donors with self-reported moderately or severely dry skin were compared to blood donors without dry skin. Blood donors with ichthyosis, lichen planus and psoriasis were excluded. Water hardness data was collected from the Geology Survey of Denmark and Greenland. Results Overall, 4,748 of 30,721 (15.5%; 95% confidence interval 15.1–15.9%) blood donors had xerosis. After excluding blood donors with ichthyosis, lichen planus and psoriasis, 4,416 blood donors (2,559 females; median age 38.4 years [interquartile range 28.0–49.8]; 700 smokers) remained in this study. Water softer than 12–24 degrees Deutsche härte was associated with decreased probability of xerosis (odds ratio 0.83; 95% confidence interval 0.74–0.94) and water harder than 12–24 degrees Deutsche härte was associated with increased probability of xerosis (odds ratio 1.22; 95% confidence interval 1.03–1.45). The association between water hardness and xerosis remained significant after excluding blood donors with dermatitis. Conclusions Water hardness is associated with xerosis independent of other dermatoses. |
author2 |
Kaliyadan, Feroze LEO Fondet |
format |
Article in Journal/Newspaper |
author |
Henning, Mattias A. S. Ibler, Kristina S. Ullum, Henrik Erikstrup, Christian Bruun, Mie T. Burgdorf, Kristoffer S. Dinh, Khoa M. Rigas, Andreas Thørner, Lise W. Pedersen, Ole B. Jemec, Gregor B. |
spellingShingle |
Henning, Mattias A. S. Ibler, Kristina S. Ullum, Henrik Erikstrup, Christian Bruun, Mie T. Burgdorf, Kristoffer S. Dinh, Khoa M. Rigas, Andreas Thørner, Lise W. Pedersen, Ole B. Jemec, Gregor B. The association between water hardness and xerosis—Results from the Danish Blood Donor Study |
author_facet |
Henning, Mattias A. S. Ibler, Kristina S. Ullum, Henrik Erikstrup, Christian Bruun, Mie T. Burgdorf, Kristoffer S. Dinh, Khoa M. Rigas, Andreas Thørner, Lise W. Pedersen, Ole B. Jemec, Gregor B. |
author_sort |
Henning, Mattias A. S. |
title |
The association between water hardness and xerosis—Results from the Danish Blood Donor Study |
title_short |
The association between water hardness and xerosis—Results from the Danish Blood Donor Study |
title_full |
The association between water hardness and xerosis—Results from the Danish Blood Donor Study |
title_fullStr |
The association between water hardness and xerosis—Results from the Danish Blood Donor Study |
title_full_unstemmed |
The association between water hardness and xerosis—Results from the Danish Blood Donor Study |
title_sort |
association between water hardness and xerosis—results from the danish blood donor study |
publisher |
Public Library of Science (PLoS) |
publishDate |
2021 |
url |
http://dx.doi.org/10.1371/journal.pone.0252462 https://dx.plos.org/10.1371/journal.pone.0252462 |
genre |
Greenland |
genre_facet |
Greenland |
op_source |
PLOS ONE volume 16, issue 6, page e0252462 ISSN 1932-6203 |
op_rights |
http://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.1371/journal.pone.0252462 |
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PLOS ONE |
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16 |
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