Estrogen therapy offsets thermal impairment of vitellogenesis, but not zonagenesis, in maiden spawning female Atlantic salmon ( Salmo salar)
In female Atlantic salmon ( Salmo salar ), exposure to warm summer temperatures causes a reduction in plasma 17β-estradiol (E2), which impairs downstream vitellogenesis and zonagenesis, and reduces egg fertility and embryo survival. The aim of the present study was to determine whether E2-treatment...
Published in: | PeerJ |
---|---|
Main Authors: | , , , |
Other Authors: | , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
PeerJ
2017
|
Subjects: | |
Online Access: | http://dx.doi.org/10.7717/peerj.3897 https://peerj.com/articles/3897.pdf https://peerj.com/articles/3897.xml https://peerj.com/articles/3897.html |
id |
crpeerj:10.7717/peerj.3897 |
---|---|
record_format |
openpolar |
spelling |
crpeerj:10.7717/peerj.3897 2024-06-02T08:03:35+00:00 Estrogen therapy offsets thermal impairment of vitellogenesis, but not zonagenesis, in maiden spawning female Atlantic salmon ( Salmo salar) Anderson, Kelli Pankhurst, Ned King, Harry Elizur, Abigail Australian Fisheries Research & Development Corporation The Australian Seafood Cooperative Research Centre Salmon Enterprises of Tasmania Pty. Ltd University of the Sunshine Coast 2017 http://dx.doi.org/10.7717/peerj.3897 https://peerj.com/articles/3897.pdf https://peerj.com/articles/3897.xml https://peerj.com/articles/3897.html en eng PeerJ http://creativecommons.org/licenses/by/4.0/ PeerJ volume 5, page e3897 ISSN 2167-8359 journal-article 2017 crpeerj https://doi.org/10.7717/peerj.3897 2024-05-07T14:13:26Z In female Atlantic salmon ( Salmo salar ), exposure to warm summer temperatures causes a reduction in plasma 17β-estradiol (E2), which impairs downstream vitellogenesis and zonagenesis, and reduces egg fertility and embryo survival. The aim of the present study was to determine whether E2-treatment could offset thermal impairment of endocrine function and maintain egg quality in maiden (first-time-spawning) S. salar reared at 22 °C. Treatment with E2 at 22 °C stimulated vitellogenin ( vtg ) gene expression and subsequent protein synthesis which promoted oocyte growth and increased egg size relative to untreated fish at 14 and 22 °C. However, E2-treatment at 22 °C was not associated with an increase in egg fertility and embryo survival relative to untreated fish at 22 °C, despite the positive effects of E2-treatment on vitellogenesis and oocyte growth. As there was no evidence to suggest that the estrogen receptor alpha expression was suppressed by high temperature, this could be due to the lack of stimulation on zonagenesis by E2-treatment observed at high temperature during oocyte development. Our results demonstrate that treatment with E2 is not able to maintain zonagenesis or egg quality in maiden S. salar at high temperature, even when vtg gene expression, protein synthesis and subsequent oocyte growth is promoted. This implies that the mechanisms regulating zonagenesis, but not vitellogenesis are impaired at elevated temperature in female S. salar broodstock, and highlights the remarkable complexity of thermally induced endocrine disruption in fish. Article in Journal/Newspaper Atlantic salmon Salmo salar PeerJ Publishing PeerJ 5 e3897 |
institution |
Open Polar |
collection |
PeerJ Publishing |
op_collection_id |
crpeerj |
language |
English |
description |
In female Atlantic salmon ( Salmo salar ), exposure to warm summer temperatures causes a reduction in plasma 17β-estradiol (E2), which impairs downstream vitellogenesis and zonagenesis, and reduces egg fertility and embryo survival. The aim of the present study was to determine whether E2-treatment could offset thermal impairment of endocrine function and maintain egg quality in maiden (first-time-spawning) S. salar reared at 22 °C. Treatment with E2 at 22 °C stimulated vitellogenin ( vtg ) gene expression and subsequent protein synthesis which promoted oocyte growth and increased egg size relative to untreated fish at 14 and 22 °C. However, E2-treatment at 22 °C was not associated with an increase in egg fertility and embryo survival relative to untreated fish at 22 °C, despite the positive effects of E2-treatment on vitellogenesis and oocyte growth. As there was no evidence to suggest that the estrogen receptor alpha expression was suppressed by high temperature, this could be due to the lack of stimulation on zonagenesis by E2-treatment observed at high temperature during oocyte development. Our results demonstrate that treatment with E2 is not able to maintain zonagenesis or egg quality in maiden S. salar at high temperature, even when vtg gene expression, protein synthesis and subsequent oocyte growth is promoted. This implies that the mechanisms regulating zonagenesis, but not vitellogenesis are impaired at elevated temperature in female S. salar broodstock, and highlights the remarkable complexity of thermally induced endocrine disruption in fish. |
author2 |
Australian Fisheries Research & Development Corporation The Australian Seafood Cooperative Research Centre Salmon Enterprises of Tasmania Pty. Ltd University of the Sunshine Coast |
format |
Article in Journal/Newspaper |
author |
Anderson, Kelli Pankhurst, Ned King, Harry Elizur, Abigail |
spellingShingle |
Anderson, Kelli Pankhurst, Ned King, Harry Elizur, Abigail Estrogen therapy offsets thermal impairment of vitellogenesis, but not zonagenesis, in maiden spawning female Atlantic salmon ( Salmo salar) |
author_facet |
Anderson, Kelli Pankhurst, Ned King, Harry Elizur, Abigail |
author_sort |
Anderson, Kelli |
title |
Estrogen therapy offsets thermal impairment of vitellogenesis, but not zonagenesis, in maiden spawning female Atlantic salmon ( Salmo salar) |
title_short |
Estrogen therapy offsets thermal impairment of vitellogenesis, but not zonagenesis, in maiden spawning female Atlantic salmon ( Salmo salar) |
title_full |
Estrogen therapy offsets thermal impairment of vitellogenesis, but not zonagenesis, in maiden spawning female Atlantic salmon ( Salmo salar) |
title_fullStr |
Estrogen therapy offsets thermal impairment of vitellogenesis, but not zonagenesis, in maiden spawning female Atlantic salmon ( Salmo salar) |
title_full_unstemmed |
Estrogen therapy offsets thermal impairment of vitellogenesis, but not zonagenesis, in maiden spawning female Atlantic salmon ( Salmo salar) |
title_sort |
estrogen therapy offsets thermal impairment of vitellogenesis, but not zonagenesis, in maiden spawning female atlantic salmon ( salmo salar) |
publisher |
PeerJ |
publishDate |
2017 |
url |
http://dx.doi.org/10.7717/peerj.3897 https://peerj.com/articles/3897.pdf https://peerj.com/articles/3897.xml https://peerj.com/articles/3897.html |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_source |
PeerJ volume 5, page e3897 ISSN 2167-8359 |
op_rights |
http://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.7717/peerj.3897 |
container_title |
PeerJ |
container_volume |
5 |
container_start_page |
e3897 |
_version_ |
1800748159673040896 |