Early Developmental Stress Affects Subsequent Gene Expression Response to an Acute Stress in Atlantic Salmon: An Approach for Creating Robust Fish for Aquaculture?
Abstract Stress during early life has potential to program and alter the response to stressful events and metabolism in later life. Repeated short exposure of Atlantic salmon to cold water and air during embryonic (E), post-hatch (PH) or both phases of development (EPH) has been shown to alter the m...
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croxfordunivpr:10.1534/g3.119.400152 2024-05-12T08:01:19+00:00 Early Developmental Stress Affects Subsequent Gene Expression Response to an Acute Stress in Atlantic Salmon: An Approach for Creating Robust Fish for Aquaculture? Robinson, Nicholas A Johnsen, Hanne Moghadam, Hooman Andersen, Øivind Tveiten, Helge 2019 http://dx.doi.org/10.1534/g3.119.400152 http://academic.oup.com/g3journal/article-pdf/9/5/1597/37178829/g3journal1597.pdf en eng Oxford University Press (OUP) https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model G3 Genes|Genomes|Genetics volume 9, issue 5, page 1597-1611 ISSN 2160-1836 Genetics (clinical) Genetics Molecular Biology journal-article 2019 croxfordunivpr https://doi.org/10.1534/g3.119.400152 2024-04-18T08:15:57Z Abstract Stress during early life has potential to program and alter the response to stressful events and metabolism in later life. Repeated short exposure of Atlantic salmon to cold water and air during embryonic (E), post-hatch (PH) or both phases of development (EPH) has been shown to alter the methylome and transcriptome and to affect growth performance during later life compared to untreated controls (CO). The aim of this study was to investigate how the transcriptome of these fish responds to subsequent acute stress at the start feeding stage, and to describe methylation differences that might steer these changes. EPH treated fish showed the strongest down-regulation of corticotropin releasing factor 1, up-regulation of glucocorticoid receptor and 3-oxo-5-alpha-steroid 4-dehydrogenase 2 gene expression and a suppressed cortisol response 3 hr after the acute stress, differences that could influence hormesis and be affecting how EPH fish cope and recover from the stress event. Growth hormone 2 and insulin-like growth factor 1 were more strongly down-regulated following acute stress in EPH treated fish relative to E, PH and CO fish. This indicates switching away from growth toward coping with stress following stressful events in EPH fish. Genes implicated in immune function such as major histocompatibility class 1A, T-cell receptor and toll-like receptor also responded to acute stress differently in EPH treated fish, indicating that repeated stresses during early life may affect robustness. Differential DNA methylation was detected in regions mapping <500 bases from genes differentially responding to acute stress suggesting the involvement of epigenetic mechanisms. Stress treatments applied during early development therefore have potential as a husbandry tool for boosting the productivity of aquaculture by affecting how fish respond to stresses at critical stages of production. Article in Journal/Newspaper Atlantic salmon Oxford University Press G3 Genes|Genomes|Genetics 9 5 1597 1611 |
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Oxford University Press |
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language |
English |
topic |
Genetics (clinical) Genetics Molecular Biology |
spellingShingle |
Genetics (clinical) Genetics Molecular Biology Robinson, Nicholas A Johnsen, Hanne Moghadam, Hooman Andersen, Øivind Tveiten, Helge Early Developmental Stress Affects Subsequent Gene Expression Response to an Acute Stress in Atlantic Salmon: An Approach for Creating Robust Fish for Aquaculture? |
topic_facet |
Genetics (clinical) Genetics Molecular Biology |
description |
Abstract Stress during early life has potential to program and alter the response to stressful events and metabolism in later life. Repeated short exposure of Atlantic salmon to cold water and air during embryonic (E), post-hatch (PH) or both phases of development (EPH) has been shown to alter the methylome and transcriptome and to affect growth performance during later life compared to untreated controls (CO). The aim of this study was to investigate how the transcriptome of these fish responds to subsequent acute stress at the start feeding stage, and to describe methylation differences that might steer these changes. EPH treated fish showed the strongest down-regulation of corticotropin releasing factor 1, up-regulation of glucocorticoid receptor and 3-oxo-5-alpha-steroid 4-dehydrogenase 2 gene expression and a suppressed cortisol response 3 hr after the acute stress, differences that could influence hormesis and be affecting how EPH fish cope and recover from the stress event. Growth hormone 2 and insulin-like growth factor 1 were more strongly down-regulated following acute stress in EPH treated fish relative to E, PH and CO fish. This indicates switching away from growth toward coping with stress following stressful events in EPH fish. Genes implicated in immune function such as major histocompatibility class 1A, T-cell receptor and toll-like receptor also responded to acute stress differently in EPH treated fish, indicating that repeated stresses during early life may affect robustness. Differential DNA methylation was detected in regions mapping <500 bases from genes differentially responding to acute stress suggesting the involvement of epigenetic mechanisms. Stress treatments applied during early development therefore have potential as a husbandry tool for boosting the productivity of aquaculture by affecting how fish respond to stresses at critical stages of production. |
format |
Article in Journal/Newspaper |
author |
Robinson, Nicholas A Johnsen, Hanne Moghadam, Hooman Andersen, Øivind Tveiten, Helge |
author_facet |
Robinson, Nicholas A Johnsen, Hanne Moghadam, Hooman Andersen, Øivind Tveiten, Helge |
author_sort |
Robinson, Nicholas A |
title |
Early Developmental Stress Affects Subsequent Gene Expression Response to an Acute Stress in Atlantic Salmon: An Approach for Creating Robust Fish for Aquaculture? |
title_short |
Early Developmental Stress Affects Subsequent Gene Expression Response to an Acute Stress in Atlantic Salmon: An Approach for Creating Robust Fish for Aquaculture? |
title_full |
Early Developmental Stress Affects Subsequent Gene Expression Response to an Acute Stress in Atlantic Salmon: An Approach for Creating Robust Fish for Aquaculture? |
title_fullStr |
Early Developmental Stress Affects Subsequent Gene Expression Response to an Acute Stress in Atlantic Salmon: An Approach for Creating Robust Fish for Aquaculture? |
title_full_unstemmed |
Early Developmental Stress Affects Subsequent Gene Expression Response to an Acute Stress in Atlantic Salmon: An Approach for Creating Robust Fish for Aquaculture? |
title_sort |
early developmental stress affects subsequent gene expression response to an acute stress in atlantic salmon: an approach for creating robust fish for aquaculture? |
publisher |
Oxford University Press (OUP) |
publishDate |
2019 |
url |
http://dx.doi.org/10.1534/g3.119.400152 http://academic.oup.com/g3journal/article-pdf/9/5/1597/37178829/g3journal1597.pdf |
genre |
Atlantic salmon |
genre_facet |
Atlantic salmon |
op_source |
G3 Genes|Genomes|Genetics volume 9, issue 5, page 1597-1611 ISSN 2160-1836 |
op_rights |
https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model |
op_doi |
https://doi.org/10.1534/g3.119.400152 |
container_title |
G3 Genes|Genomes|Genetics |
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9 |
container_issue |
5 |
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1597 |
op_container_end_page |
1611 |
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