Genome-Wide Association and Genomic Selection for Resistance to Amoebic Gill Disease in Atlantic Salmon
Abstract Amoebic gill disease (AGD) is one of the largest threats to salmon aquaculture, causing serious economic and animal welfare burden. Treatments can be expensive and environmentally damaging, hence the need for alternative strategies. Breeding for disease resistance can contribute to preventi...
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Online Access: | http://dx.doi.org/10.1534/g3.118.200075 http://academic.oup.com/g3journal/article-pdf/8/4/1195/40573984/g3journal1195.pdf |
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croxfordunivpr:10.1534/g3.118.200075 2024-06-23T07:51:16+00:00 Genome-Wide Association and Genomic Selection for Resistance to Amoebic Gill Disease in Atlantic Salmon Robledo, Diego Matika, Oswald Hamilton, Alastair Houston, Ross D 2018 http://dx.doi.org/10.1534/g3.118.200075 http://academic.oup.com/g3journal/article-pdf/8/4/1195/40573984/g3journal1195.pdf en eng Oxford University Press (OUP) https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model G3 Genes|Genomes|Genetics volume 8, issue 4, page 1195-1203 ISSN 2160-1836 journal-article 2018 croxfordunivpr https://doi.org/10.1534/g3.118.200075 2024-06-04T06:15:11Z Abstract Amoebic gill disease (AGD) is one of the largest threats to salmon aquaculture, causing serious economic and animal welfare burden. Treatments can be expensive and environmentally damaging, hence the need for alternative strategies. Breeding for disease resistance can contribute to prevention and control of AGD, providing long-term cumulative benefits in selected stocks. The use of genomic selection can expedite selection for disease resistance due to improved accuracy compared to pedigree-based approaches. The aim of this work was to quantify and characterize genetic variation in AGD resistance in salmon, the genetic architecture of the trait, and the potential of genomic selection to contribute to disease control. An AGD challenge was performed in ∼1,500 Atlantic salmon, using gill damage and amoebic load as indicator traits for host resistance. Both traits are heritable (h2 ∼0.25-0.30) and show high positive correlation, indicating they may be good measurements of host resistance to AGD. While the genetic architecture of resistance appeared to be largely polygenic in nature, two regions on chromosome 18 showed suggestive association with both AGD resistance traits. Using a cross-validation approach, genomic prediction accuracy was up to 18% higher than that obtained using pedigree, and a reduction in marker density to ∼2,000 SNPs was sufficient to obtain accuracies similar to those obtained using the whole dataset. This study indicates that resistance to AGD is a suitable trait for genomic selection, and the addition of this trait to Atlantic salmon breeding programs can lead to more resistant stocks. Article in Journal/Newspaper Atlantic salmon Oxford University Press G3 Genes|Genomes|Genetics 8 4 1195 1203 |
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Open Polar |
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Oxford University Press |
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croxfordunivpr |
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English |
description |
Abstract Amoebic gill disease (AGD) is one of the largest threats to salmon aquaculture, causing serious economic and animal welfare burden. Treatments can be expensive and environmentally damaging, hence the need for alternative strategies. Breeding for disease resistance can contribute to prevention and control of AGD, providing long-term cumulative benefits in selected stocks. The use of genomic selection can expedite selection for disease resistance due to improved accuracy compared to pedigree-based approaches. The aim of this work was to quantify and characterize genetic variation in AGD resistance in salmon, the genetic architecture of the trait, and the potential of genomic selection to contribute to disease control. An AGD challenge was performed in ∼1,500 Atlantic salmon, using gill damage and amoebic load as indicator traits for host resistance. Both traits are heritable (h2 ∼0.25-0.30) and show high positive correlation, indicating they may be good measurements of host resistance to AGD. While the genetic architecture of resistance appeared to be largely polygenic in nature, two regions on chromosome 18 showed suggestive association with both AGD resistance traits. Using a cross-validation approach, genomic prediction accuracy was up to 18% higher than that obtained using pedigree, and a reduction in marker density to ∼2,000 SNPs was sufficient to obtain accuracies similar to those obtained using the whole dataset. This study indicates that resistance to AGD is a suitable trait for genomic selection, and the addition of this trait to Atlantic salmon breeding programs can lead to more resistant stocks. |
format |
Article in Journal/Newspaper |
author |
Robledo, Diego Matika, Oswald Hamilton, Alastair Houston, Ross D |
spellingShingle |
Robledo, Diego Matika, Oswald Hamilton, Alastair Houston, Ross D Genome-Wide Association and Genomic Selection for Resistance to Amoebic Gill Disease in Atlantic Salmon |
author_facet |
Robledo, Diego Matika, Oswald Hamilton, Alastair Houston, Ross D |
author_sort |
Robledo, Diego |
title |
Genome-Wide Association and Genomic Selection for Resistance to Amoebic Gill Disease in Atlantic Salmon |
title_short |
Genome-Wide Association and Genomic Selection for Resistance to Amoebic Gill Disease in Atlantic Salmon |
title_full |
Genome-Wide Association and Genomic Selection for Resistance to Amoebic Gill Disease in Atlantic Salmon |
title_fullStr |
Genome-Wide Association and Genomic Selection for Resistance to Amoebic Gill Disease in Atlantic Salmon |
title_full_unstemmed |
Genome-Wide Association and Genomic Selection for Resistance to Amoebic Gill Disease in Atlantic Salmon |
title_sort |
genome-wide association and genomic selection for resistance to amoebic gill disease in atlantic salmon |
publisher |
Oxford University Press (OUP) |
publishDate |
2018 |
url |
http://dx.doi.org/10.1534/g3.118.200075 http://academic.oup.com/g3journal/article-pdf/8/4/1195/40573984/g3journal1195.pdf |
genre |
Atlantic salmon |
genre_facet |
Atlantic salmon |
op_source |
G3 Genes|Genomes|Genetics volume 8, issue 4, page 1195-1203 ISSN 2160-1836 |
op_rights |
https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model |
op_doi |
https://doi.org/10.1534/g3.118.200075 |
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G3 Genes|Genomes|Genetics |
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8 |
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4 |
container_start_page |
1195 |
op_container_end_page |
1203 |
_version_ |
1802642308578934784 |