Clinical and biochemical signs of polycystic ovary syndrome in young women born preterm
Objective It has been suggested that adverse early life exposures increase the risk of developing polycystic ovary syndrome (PCOS) in later life. We hypothesized that women born preterm would have more biochemical and clinical signs of PCOS than women born at term. Design The ESTER Preterm Birth Stu...
Published in: | European Journal of Endocrinology |
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Oxford University Press (OUP)
2021
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croxfordunivpr:10.1530/eje-20-1462 2023-09-26T15:21:21+02:00 Clinical and biochemical signs of polycystic ovary syndrome in young women born preterm Paalanne, Marika Vääräsmäki, Marja Mustaniemi, Sanna Tikanmäki, Marjaana Wehkalampi, Karoliina Matinolli, Hanna-Maria Eriksson, Johan Järvelin, Marjo-Riitta Morin-Papunen, Laure Kajantie, Eero 2021 http://dx.doi.org/10.1530/eje-20-1462 https://eje.bioscientifica.com/view/journals/eje/185/2/EJE-20-1462.xml https://eje.bioscientifica.com/downloadpdf/journals/eje/185/2/EJE-20-1462.xml unknown Oxford University Press (OUP) http://creativecommons.org/licenses/by/4.0/ European Journal of Endocrinology volume 185, issue 2, page 279-288 ISSN 0804-4643 1479-683X Endocrinology General Medicine Endocrinology, Diabetes and Metabolism journal-article 2021 croxfordunivpr https://doi.org/10.1530/eje-20-1462 2023-08-25T11:35:14Z Objective It has been suggested that adverse early life exposures increase the risk of developing polycystic ovary syndrome (PCOS) in later life. We hypothesized that women born preterm would have more biochemical and clinical signs of PCOS than women born at term. Design The ESTER Preterm Birth Study participants were born in Northern Finland and identified from the Northern Finland Birth Cohort and the Finnish Medical Birth Register. Altogether, 74 women born very or moderately preterm (<34 gestational weeks, VMPT), 127 born late preterm (at 34–36 weeks, LPT), and 184 born full term (≥37 weeks, controls) were included in the analysis (mean age: 23.2 years). Methods We measured serum total testosterone and sex hormone-binding globulin (SHBG) and calculated the free androgen index (FAI). PCOS according to the clinical and biochemical signs was defined either as hirsutism and oligoamenorrhea (via questionnaire) or as oligoamenorrhea and elevated testosterone levels (>2.4 nmol/L). Results Women born VMPT/LPT exhibited 33.0% (8.7, 62.8)/16.4% (−2.0, 38.1) higher testosterone, 28.5% (5.3, 45.9)/24.1% (5.6, 38.9) lower SHBG levels, and 64.6% (19.4, 127.1)/42.5% (11.1, 82.9) higher FAI than controls after adjusting for age and recruitment cohort, maternal BMI, smoking, and pregnancy disorders, parental education, history of hypertension, diabetes, myocardial infarction or stroke, and subject’s birth weight s.d. Odds ratios for having PCOS were 1.67 (0.44, 6.23)/3.11 (1.26, 7.70). Conclusions Women born preterm have a more hyperandrogenic hormonal profile, and those born LPT are approximately three times more likely at risk to have PCOS compared to women born at term. Article in Journal/Newspaper Northern Finland Oxford University Press (via Crossref) European Journal of Endocrinology 185 2 279 288 |
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Oxford University Press (via Crossref) |
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croxfordunivpr |
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topic |
Endocrinology General Medicine Endocrinology, Diabetes and Metabolism |
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Endocrinology General Medicine Endocrinology, Diabetes and Metabolism Paalanne, Marika Vääräsmäki, Marja Mustaniemi, Sanna Tikanmäki, Marjaana Wehkalampi, Karoliina Matinolli, Hanna-Maria Eriksson, Johan Järvelin, Marjo-Riitta Morin-Papunen, Laure Kajantie, Eero Clinical and biochemical signs of polycystic ovary syndrome in young women born preterm |
topic_facet |
Endocrinology General Medicine Endocrinology, Diabetes and Metabolism |
description |
Objective It has been suggested that adverse early life exposures increase the risk of developing polycystic ovary syndrome (PCOS) in later life. We hypothesized that women born preterm would have more biochemical and clinical signs of PCOS than women born at term. Design The ESTER Preterm Birth Study participants were born in Northern Finland and identified from the Northern Finland Birth Cohort and the Finnish Medical Birth Register. Altogether, 74 women born very or moderately preterm (<34 gestational weeks, VMPT), 127 born late preterm (at 34–36 weeks, LPT), and 184 born full term (≥37 weeks, controls) were included in the analysis (mean age: 23.2 years). Methods We measured serum total testosterone and sex hormone-binding globulin (SHBG) and calculated the free androgen index (FAI). PCOS according to the clinical and biochemical signs was defined either as hirsutism and oligoamenorrhea (via questionnaire) or as oligoamenorrhea and elevated testosterone levels (>2.4 nmol/L). Results Women born VMPT/LPT exhibited 33.0% (8.7, 62.8)/16.4% (−2.0, 38.1) higher testosterone, 28.5% (5.3, 45.9)/24.1% (5.6, 38.9) lower SHBG levels, and 64.6% (19.4, 127.1)/42.5% (11.1, 82.9) higher FAI than controls after adjusting for age and recruitment cohort, maternal BMI, smoking, and pregnancy disorders, parental education, history of hypertension, diabetes, myocardial infarction or stroke, and subject’s birth weight s.d. Odds ratios for having PCOS were 1.67 (0.44, 6.23)/3.11 (1.26, 7.70). Conclusions Women born preterm have a more hyperandrogenic hormonal profile, and those born LPT are approximately three times more likely at risk to have PCOS compared to women born at term. |
format |
Article in Journal/Newspaper |
author |
Paalanne, Marika Vääräsmäki, Marja Mustaniemi, Sanna Tikanmäki, Marjaana Wehkalampi, Karoliina Matinolli, Hanna-Maria Eriksson, Johan Järvelin, Marjo-Riitta Morin-Papunen, Laure Kajantie, Eero |
author_facet |
Paalanne, Marika Vääräsmäki, Marja Mustaniemi, Sanna Tikanmäki, Marjaana Wehkalampi, Karoliina Matinolli, Hanna-Maria Eriksson, Johan Järvelin, Marjo-Riitta Morin-Papunen, Laure Kajantie, Eero |
author_sort |
Paalanne, Marika |
title |
Clinical and biochemical signs of polycystic ovary syndrome in young women born preterm |
title_short |
Clinical and biochemical signs of polycystic ovary syndrome in young women born preterm |
title_full |
Clinical and biochemical signs of polycystic ovary syndrome in young women born preterm |
title_fullStr |
Clinical and biochemical signs of polycystic ovary syndrome in young women born preterm |
title_full_unstemmed |
Clinical and biochemical signs of polycystic ovary syndrome in young women born preterm |
title_sort |
clinical and biochemical signs of polycystic ovary syndrome in young women born preterm |
publisher |
Oxford University Press (OUP) |
publishDate |
2021 |
url |
http://dx.doi.org/10.1530/eje-20-1462 https://eje.bioscientifica.com/view/journals/eje/185/2/EJE-20-1462.xml https://eje.bioscientifica.com/downloadpdf/journals/eje/185/2/EJE-20-1462.xml |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_source |
European Journal of Endocrinology volume 185, issue 2, page 279-288 ISSN 0804-4643 1479-683X |
op_rights |
http://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.1530/eje-20-1462 |
container_title |
European Journal of Endocrinology |
container_volume |
185 |
container_issue |
2 |
container_start_page |
279 |
op_container_end_page |
288 |
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1778146021311774720 |