Primary Hyperparathyroidism and Osteosarcoma: Examination of a Large Cohort Identifies Three Cases of Fibroblastic Osteosarcoma
Abstract To study a possible relationship between hyperparathyroidism and osteosarcoma, we reviewed 1234 osteosarcoma patients. In this cohort, only three patients had a diagnosis of both hyperparathyroidism and fibroblastic osteosarcoma. These results indicate that hyperparathyroidism is not more p...
Published in: | Journal of Bone and Mineral Research |
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Oxford University Press (OUP)
2005
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Online Access: | http://dx.doi.org/10.1359/jbmr.050507 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1359%2FJBMR.050507 https://academic.oup.com/jbmr/article-pdf/20/9/1562/56477424/5650200908.pdf |
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croxfordunivpr:10.1359/jbmr.050507 2024-03-03T08:49:09+00:00 Primary Hyperparathyroidism and Osteosarcoma: Examination of a Large Cohort Identifies Three Cases of Fibroblastic Osteosarcoma Jimenez, Camilo Yang, Ying Kim, Hyung-Woo Al-Sagier, Fozia Berry, Donald A El-Naggar, Adel K. Patel, Shreyaskumar Vassilopoulou-Sellin, Rena Gagel, Robert F 2005 http://dx.doi.org/10.1359/jbmr.050507 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1359%2FJBMR.050507 https://academic.oup.com/jbmr/article-pdf/20/9/1562/56477424/5650200908.pdf en eng Oxford University Press (OUP) https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model Journal of Bone and Mineral Research volume 20, issue 9, page 1562-1568 ISSN 0884-0431 1523-4681 Orthopedics and Sports Medicine Endocrinology, Diabetes and Metabolism journal-article 2005 croxfordunivpr https://doi.org/10.1359/jbmr.050507 2024-02-05T10:34:51Z Abstract To study a possible relationship between hyperparathyroidism and osteosarcoma, we reviewed 1234 osteosarcoma patients. In this cohort, only three patients had a diagnosis of both hyperparathyroidism and fibroblastic osteosarcoma. These results indicate that hyperparathyroidism is not more prevalent in patients with osteosarcoma than in the general population. However, the presence of hyperparathyroidism may modify the histologic and cytologic features of osteosarcoma. Introduction: The finding of osteosarcoma in rats receiving human PTH(1-34) raised the question of whether hyperparathyroidism might be a risk factor for development of osteosarcoma in humans. Materials and Methods: To study a possible relationship between hyperparathyroidism and osteosarcoma, we reviewed the medical records of 1234 osteosarcoma patients seen at The M.D. Anderson Cancer Center since 1948. Our study focused on clinical, biochemical, radiologic, and histopathologic findings indicative of primary hyperparathyroidism and the features of osteosarcoma. Results: Of the 1234 cases reviewed, 3 patients had a diagnosis of both primary hyperparathyroidism and osteosarcoma. In two cases, hyperparathyroidism preceded the osteosarcoma, and in one case, both conditions were diagnosed at the same time. In two cases with concomitant hyperparathyroidism and osteosarcoma, features of osteitis fibrocystica were identified. The third patient was treated for hyperparathyroidism 3 years before osteosarcoma was diagnosed. All three patients had histologic features of fibroblastic osteosarcoma, a type that accounts for no more than 20% of osteosarcomas. To assess whether the prevalence of hyperparathyroidism was greater than expected in the normal population, we compared the age- and sex-specific prevalence in our cohort to a population of healthy individuals in Tromso, Norway. This analysis showed no significant differences between the two populations, despite the fact that a higher prevalence of hyperparathyroidism (6.9% versus 1.6%) was noted ... Article in Journal/Newspaper Tromso Tromso Oxford University Press Norway Tromso ENVELOPE(16.546,16.546,68.801,68.801) Journal of Bone and Mineral Research 20 9 1562 1568 |
institution |
Open Polar |
collection |
Oxford University Press |
op_collection_id |
croxfordunivpr |
language |
English |
topic |
Orthopedics and Sports Medicine Endocrinology, Diabetes and Metabolism |
spellingShingle |
Orthopedics and Sports Medicine Endocrinology, Diabetes and Metabolism Jimenez, Camilo Yang, Ying Kim, Hyung-Woo Al-Sagier, Fozia Berry, Donald A El-Naggar, Adel K. Patel, Shreyaskumar Vassilopoulou-Sellin, Rena Gagel, Robert F Primary Hyperparathyroidism and Osteosarcoma: Examination of a Large Cohort Identifies Three Cases of Fibroblastic Osteosarcoma |
topic_facet |
Orthopedics and Sports Medicine Endocrinology, Diabetes and Metabolism |
description |
Abstract To study a possible relationship between hyperparathyroidism and osteosarcoma, we reviewed 1234 osteosarcoma patients. In this cohort, only three patients had a diagnosis of both hyperparathyroidism and fibroblastic osteosarcoma. These results indicate that hyperparathyroidism is not more prevalent in patients with osteosarcoma than in the general population. However, the presence of hyperparathyroidism may modify the histologic and cytologic features of osteosarcoma. Introduction: The finding of osteosarcoma in rats receiving human PTH(1-34) raised the question of whether hyperparathyroidism might be a risk factor for development of osteosarcoma in humans. Materials and Methods: To study a possible relationship between hyperparathyroidism and osteosarcoma, we reviewed the medical records of 1234 osteosarcoma patients seen at The M.D. Anderson Cancer Center since 1948. Our study focused on clinical, biochemical, radiologic, and histopathologic findings indicative of primary hyperparathyroidism and the features of osteosarcoma. Results: Of the 1234 cases reviewed, 3 patients had a diagnosis of both primary hyperparathyroidism and osteosarcoma. In two cases, hyperparathyroidism preceded the osteosarcoma, and in one case, both conditions were diagnosed at the same time. In two cases with concomitant hyperparathyroidism and osteosarcoma, features of osteitis fibrocystica were identified. The third patient was treated for hyperparathyroidism 3 years before osteosarcoma was diagnosed. All three patients had histologic features of fibroblastic osteosarcoma, a type that accounts for no more than 20% of osteosarcomas. To assess whether the prevalence of hyperparathyroidism was greater than expected in the normal population, we compared the age- and sex-specific prevalence in our cohort to a population of healthy individuals in Tromso, Norway. This analysis showed no significant differences between the two populations, despite the fact that a higher prevalence of hyperparathyroidism (6.9% versus 1.6%) was noted ... |
format |
Article in Journal/Newspaper |
author |
Jimenez, Camilo Yang, Ying Kim, Hyung-Woo Al-Sagier, Fozia Berry, Donald A El-Naggar, Adel K. Patel, Shreyaskumar Vassilopoulou-Sellin, Rena Gagel, Robert F |
author_facet |
Jimenez, Camilo Yang, Ying Kim, Hyung-Woo Al-Sagier, Fozia Berry, Donald A El-Naggar, Adel K. Patel, Shreyaskumar Vassilopoulou-Sellin, Rena Gagel, Robert F |
author_sort |
Jimenez, Camilo |
title |
Primary Hyperparathyroidism and Osteosarcoma: Examination of a Large Cohort Identifies Three Cases of Fibroblastic Osteosarcoma |
title_short |
Primary Hyperparathyroidism and Osteosarcoma: Examination of a Large Cohort Identifies Three Cases of Fibroblastic Osteosarcoma |
title_full |
Primary Hyperparathyroidism and Osteosarcoma: Examination of a Large Cohort Identifies Three Cases of Fibroblastic Osteosarcoma |
title_fullStr |
Primary Hyperparathyroidism and Osteosarcoma: Examination of a Large Cohort Identifies Three Cases of Fibroblastic Osteosarcoma |
title_full_unstemmed |
Primary Hyperparathyroidism and Osteosarcoma: Examination of a Large Cohort Identifies Three Cases of Fibroblastic Osteosarcoma |
title_sort |
primary hyperparathyroidism and osteosarcoma: examination of a large cohort identifies three cases of fibroblastic osteosarcoma |
publisher |
Oxford University Press (OUP) |
publishDate |
2005 |
url |
http://dx.doi.org/10.1359/jbmr.050507 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1359%2FJBMR.050507 https://academic.oup.com/jbmr/article-pdf/20/9/1562/56477424/5650200908.pdf |
long_lat |
ENVELOPE(16.546,16.546,68.801,68.801) |
geographic |
Norway Tromso |
geographic_facet |
Norway Tromso |
genre |
Tromso Tromso |
genre_facet |
Tromso Tromso |
op_source |
Journal of Bone and Mineral Research volume 20, issue 9, page 1562-1568 ISSN 0884-0431 1523-4681 |
op_rights |
https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model |
op_doi |
https://doi.org/10.1359/jbmr.050507 |
container_title |
Journal of Bone and Mineral Research |
container_volume |
20 |
container_issue |
9 |
container_start_page |
1562 |
op_container_end_page |
1568 |
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1792506318944206848 |