Cod liver oil supplementation improves cardiovascular and metabolic abnormalities in streptozotocin diabetic rats
Abstract Abnormalities in the metabolism of essential fatty acids and the results of increased oxidative stress have been implicated in cardiovascular disorders observed in diabetes mellitus. This study, therefore, aimed to investigate the effects of cod liver oil (CLO, Lysi Ltd, Iceland), which com...
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Oxford University Press (OUP)
2007
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Online Access: | http://dx.doi.org/10.1211/jpp.59.12.0004 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1211%2Fjpp.59.12.0004 http://academic.oup.com/jpp/article-pdf/59/12/1629/36738625/jpp.59.12.0004.pdf |
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croxfordunivpr:10.1211/jpp.59.12.0004 2023-12-31T10:08:24+01:00 Cod liver oil supplementation improves cardiovascular and metabolic abnormalities in streptozotocin diabetic rats Ceylan-Isık, Aslı Hünkar, Tuǧba Aşan, Esin Kaymaz, Fugen Arı, Nuray Söylemezoǧlu, Tülin Renda, Nurten Soncul, Halim Bali, Musa Karasu, Çimen 2007 http://dx.doi.org/10.1211/jpp.59.12.0004 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1211%2Fjpp.59.12.0004 http://academic.oup.com/jpp/article-pdf/59/12/1629/36738625/jpp.59.12.0004.pdf en eng Oxford University Press (OUP) https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model Journal of Pharmacy and Pharmacology volume 59, issue 12, page 1629-1641 ISSN 0022-3573 2042-7158 Pharmaceutical Science Pharmacology journal-article 2007 croxfordunivpr https://doi.org/10.1211/jpp.59.12.0004 2023-12-06T08:37:14Z Abstract Abnormalities in the metabolism of essential fatty acids and the results of increased oxidative stress have been implicated in cardiovascular disorders observed in diabetes mellitus. This study, therefore, aimed to investigate the effects of cod liver oil (CLO, Lysi Ltd, Iceland), which comprises mainly an antioxidant vitamin A, n:3 polyunsaturated fatty acids (n:3 PUFAs), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), on cardiovascular abnormalities in streptozotocin (STZ)-diabetic rats. Two days after single STZ (55 mg kg−1, i.p.) or vehicle injection, diabetes was verified by increased blood glucose, and non-diabetic and diabetic rats were left untreated or treated with CLO (0.5 mL kg−1 daily, by intragastric probing) for 12 weeks. Plasma glucose, triacylglycerol and cholesterol concentrations were significantly elevated in 12-week untreated-diabetic rats; CLO provided better weight gain, entirely prevented the plasma lipid abnormalities, but partially controlled the glycaemia in diabetic rats. In isolated aorta rings, diabetes resulted in increased phenylephrine-induced vasoconstriction and isoprenaline-induced vasorelaxation, impaired endothelium-dependent vasodilatation and unchanged responsiveness to sodium nitroprusside. CLO treatment completely prevented endothelial deficiency, partly corrected the phenylephrine-induced vasoconstriction and did not affect the responses to isoprenaline and sodium nitroprusside in diabetic aorta. Diabetes also produced a marked decrease in the rate of spontaneously beating right atria and a significant increase in basal contractile force of left ventricular papillary muscle. The responsiveness of right atria to the positive chronotropic effect of isoprenaline was significantly decreased in diabetic rats, and was increased in CLO-treated diabetic rats. The positive chronotropic effect of noradrenaline was markedly increased in diabetic atria, but prevented by CLO treatment. Diabetes also resulted in an increased positive inotropic response of ... Article in Journal/Newspaper Iceland Oxford University Press (via Crossref) Journal of Pharmacy and Pharmacology 59 12 1629 1641 |
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Oxford University Press (via Crossref) |
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English |
topic |
Pharmaceutical Science Pharmacology |
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Pharmaceutical Science Pharmacology Ceylan-Isık, Aslı Hünkar, Tuǧba Aşan, Esin Kaymaz, Fugen Arı, Nuray Söylemezoǧlu, Tülin Renda, Nurten Soncul, Halim Bali, Musa Karasu, Çimen Cod liver oil supplementation improves cardiovascular and metabolic abnormalities in streptozotocin diabetic rats |
topic_facet |
Pharmaceutical Science Pharmacology |
description |
Abstract Abnormalities in the metabolism of essential fatty acids and the results of increased oxidative stress have been implicated in cardiovascular disorders observed in diabetes mellitus. This study, therefore, aimed to investigate the effects of cod liver oil (CLO, Lysi Ltd, Iceland), which comprises mainly an antioxidant vitamin A, n:3 polyunsaturated fatty acids (n:3 PUFAs), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), on cardiovascular abnormalities in streptozotocin (STZ)-diabetic rats. Two days after single STZ (55 mg kg−1, i.p.) or vehicle injection, diabetes was verified by increased blood glucose, and non-diabetic and diabetic rats were left untreated or treated with CLO (0.5 mL kg−1 daily, by intragastric probing) for 12 weeks. Plasma glucose, triacylglycerol and cholesterol concentrations were significantly elevated in 12-week untreated-diabetic rats; CLO provided better weight gain, entirely prevented the plasma lipid abnormalities, but partially controlled the glycaemia in diabetic rats. In isolated aorta rings, diabetes resulted in increased phenylephrine-induced vasoconstriction and isoprenaline-induced vasorelaxation, impaired endothelium-dependent vasodilatation and unchanged responsiveness to sodium nitroprusside. CLO treatment completely prevented endothelial deficiency, partly corrected the phenylephrine-induced vasoconstriction and did not affect the responses to isoprenaline and sodium nitroprusside in diabetic aorta. Diabetes also produced a marked decrease in the rate of spontaneously beating right atria and a significant increase in basal contractile force of left ventricular papillary muscle. The responsiveness of right atria to the positive chronotropic effect of isoprenaline was significantly decreased in diabetic rats, and was increased in CLO-treated diabetic rats. The positive chronotropic effect of noradrenaline was markedly increased in diabetic atria, but prevented by CLO treatment. Diabetes also resulted in an increased positive inotropic response of ... |
format |
Article in Journal/Newspaper |
author |
Ceylan-Isık, Aslı Hünkar, Tuǧba Aşan, Esin Kaymaz, Fugen Arı, Nuray Söylemezoǧlu, Tülin Renda, Nurten Soncul, Halim Bali, Musa Karasu, Çimen |
author_facet |
Ceylan-Isık, Aslı Hünkar, Tuǧba Aşan, Esin Kaymaz, Fugen Arı, Nuray Söylemezoǧlu, Tülin Renda, Nurten Soncul, Halim Bali, Musa Karasu, Çimen |
author_sort |
Ceylan-Isık, Aslı |
title |
Cod liver oil supplementation improves cardiovascular and metabolic abnormalities in streptozotocin diabetic rats |
title_short |
Cod liver oil supplementation improves cardiovascular and metabolic abnormalities in streptozotocin diabetic rats |
title_full |
Cod liver oil supplementation improves cardiovascular and metabolic abnormalities in streptozotocin diabetic rats |
title_fullStr |
Cod liver oil supplementation improves cardiovascular and metabolic abnormalities in streptozotocin diabetic rats |
title_full_unstemmed |
Cod liver oil supplementation improves cardiovascular and metabolic abnormalities in streptozotocin diabetic rats |
title_sort |
cod liver oil supplementation improves cardiovascular and metabolic abnormalities in streptozotocin diabetic rats |
publisher |
Oxford University Press (OUP) |
publishDate |
2007 |
url |
http://dx.doi.org/10.1211/jpp.59.12.0004 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1211%2Fjpp.59.12.0004 http://academic.oup.com/jpp/article-pdf/59/12/1629/36738625/jpp.59.12.0004.pdf |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
Journal of Pharmacy and Pharmacology volume 59, issue 12, page 1629-1641 ISSN 0022-3573 2042-7158 |
op_rights |
https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model |
op_doi |
https://doi.org/10.1211/jpp.59.12.0004 |
container_title |
Journal of Pharmacy and Pharmacology |
container_volume |
59 |
container_issue |
12 |
container_start_page |
1629 |
op_container_end_page |
1641 |
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1786841108192428032 |