Secondary prevention care and effect: Total and low-density lipoprotein cholesterol levels and lipid-lowering drug use in women and men after incident myocardial infarction – The Tromsø Study 1994–2016
Background: Secondary prevention guidelines after myocardial infarction (MI) are gender neutral, but underutilisation of treatment in women has been reported. Design: We investigated the change in total and low-density lipoprotein (LDL) cholesterol levels and lipid-lowering drug (LLD) use after firs...
Published in: | European Journal of Cardiovascular Nursing |
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2018
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Online Access: | http://dx.doi.org/10.1177/1474515118762541 http://journals.sagepub.com/doi/pdf/10.1177/1474515118762541 http://journals.sagepub.com/doi/full-xml/10.1177/1474515118762541 |
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croxfordunivpr:10.1177/1474515118762541 2024-06-23T07:57:13+00:00 Secondary prevention care and effect: Total and low-density lipoprotein cholesterol levels and lipid-lowering drug use in women and men after incident myocardial infarction – The Tromsø Study 1994–2016 Hopstock, Laila A Eggen, Anne Elise Løchen, Maja-Lisa Mathiesen, Ellisiv B Njølstad, Inger Wilsgaard, Tom 2018 http://dx.doi.org/10.1177/1474515118762541 http://journals.sagepub.com/doi/pdf/10.1177/1474515118762541 http://journals.sagepub.com/doi/full-xml/10.1177/1474515118762541 en eng Oxford University Press (OUP) http://journals.sagepub.com/page/policies/text-and-data-mining-license European Journal of Cardiovascular Nursing volume 17, issue 6, page 563-570 ISSN 1474-5151 1873-1953 journal-article 2018 croxfordunivpr https://doi.org/10.1177/1474515118762541 2024-06-11T04:17:23Z Background: Secondary prevention guidelines after myocardial infarction (MI) are gender neutral, but underutilisation of treatment in women has been reported. Design: We investigated the change in total and low-density lipoprotein (LDL) cholesterol levels and lipid-lowering drug (LLD) use after first-ever MI in a population-based study. Methods: We followed 10,005 participants (54% women) attending the Tromsø Study 1994–1995 and 8483 participants (55% women) attending the Tromsø Study 2007–2008 for first-ever MI up to their participation in 2007–2008 and 2015–2016, respectively. We used linear and logistic regression models to investigate sex differences in change in lipid levels. Results: A total of 395 (MI cohort I) and 132 participants (MI cohort II) had a first-ever MI during 1994–2008 and 2007–2013, respectively. Mean change in total cholesterol was −2.34 mmol/L (SD 1.15) in MI cohort I, and in LDL cholesterol was −1.63 mmol/L (SD 1.12) in MI cohort II. Men had a larger decrease in lipid levels compared to women: the linear regression coefficient for change was −0.33 (95% confidence interval [CI] −0.51 to −0.14) for total cholesterol and −0.21 (95% CI −0.37 to −0.04) for LDL cholesterol, adjusted for baseline lipid value, age and cohort. Men had 73% higher odds (95% CI 1.15−2.61) of treatment target achievement compared to women, adjusted for baseline lipid value, age and cohort. LLD use was reported in 85% of women and 92% of men in MI cohort I, and 80% in women and 89% in men in MI cohort II. Conclusions: Compared to men, women had significantly less decrease in lipid levels after MI, and a smaller proportion of women achieved the treatment target. Article in Journal/Newspaper Tromsø Oxford University Press Tromsø European Journal of Cardiovascular Nursing 17 6 563 570 |
institution |
Open Polar |
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Oxford University Press |
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croxfordunivpr |
language |
English |
description |
Background: Secondary prevention guidelines after myocardial infarction (MI) are gender neutral, but underutilisation of treatment in women has been reported. Design: We investigated the change in total and low-density lipoprotein (LDL) cholesterol levels and lipid-lowering drug (LLD) use after first-ever MI in a population-based study. Methods: We followed 10,005 participants (54% women) attending the Tromsø Study 1994–1995 and 8483 participants (55% women) attending the Tromsø Study 2007–2008 for first-ever MI up to their participation in 2007–2008 and 2015–2016, respectively. We used linear and logistic regression models to investigate sex differences in change in lipid levels. Results: A total of 395 (MI cohort I) and 132 participants (MI cohort II) had a first-ever MI during 1994–2008 and 2007–2013, respectively. Mean change in total cholesterol was −2.34 mmol/L (SD 1.15) in MI cohort I, and in LDL cholesterol was −1.63 mmol/L (SD 1.12) in MI cohort II. Men had a larger decrease in lipid levels compared to women: the linear regression coefficient for change was −0.33 (95% confidence interval [CI] −0.51 to −0.14) for total cholesterol and −0.21 (95% CI −0.37 to −0.04) for LDL cholesterol, adjusted for baseline lipid value, age and cohort. Men had 73% higher odds (95% CI 1.15−2.61) of treatment target achievement compared to women, adjusted for baseline lipid value, age and cohort. LLD use was reported in 85% of women and 92% of men in MI cohort I, and 80% in women and 89% in men in MI cohort II. Conclusions: Compared to men, women had significantly less decrease in lipid levels after MI, and a smaller proportion of women achieved the treatment target. |
format |
Article in Journal/Newspaper |
author |
Hopstock, Laila A Eggen, Anne Elise Løchen, Maja-Lisa Mathiesen, Ellisiv B Njølstad, Inger Wilsgaard, Tom |
spellingShingle |
Hopstock, Laila A Eggen, Anne Elise Løchen, Maja-Lisa Mathiesen, Ellisiv B Njølstad, Inger Wilsgaard, Tom Secondary prevention care and effect: Total and low-density lipoprotein cholesterol levels and lipid-lowering drug use in women and men after incident myocardial infarction – The Tromsø Study 1994–2016 |
author_facet |
Hopstock, Laila A Eggen, Anne Elise Løchen, Maja-Lisa Mathiesen, Ellisiv B Njølstad, Inger Wilsgaard, Tom |
author_sort |
Hopstock, Laila A |
title |
Secondary prevention care and effect: Total and low-density lipoprotein cholesterol levels and lipid-lowering drug use in women and men after incident myocardial infarction – The Tromsø Study 1994–2016 |
title_short |
Secondary prevention care and effect: Total and low-density lipoprotein cholesterol levels and lipid-lowering drug use in women and men after incident myocardial infarction – The Tromsø Study 1994–2016 |
title_full |
Secondary prevention care and effect: Total and low-density lipoprotein cholesterol levels and lipid-lowering drug use in women and men after incident myocardial infarction – The Tromsø Study 1994–2016 |
title_fullStr |
Secondary prevention care and effect: Total and low-density lipoprotein cholesterol levels and lipid-lowering drug use in women and men after incident myocardial infarction – The Tromsø Study 1994–2016 |
title_full_unstemmed |
Secondary prevention care and effect: Total and low-density lipoprotein cholesterol levels and lipid-lowering drug use in women and men after incident myocardial infarction – The Tromsø Study 1994–2016 |
title_sort |
secondary prevention care and effect: total and low-density lipoprotein cholesterol levels and lipid-lowering drug use in women and men after incident myocardial infarction – the tromsø study 1994–2016 |
publisher |
Oxford University Press (OUP) |
publishDate |
2018 |
url |
http://dx.doi.org/10.1177/1474515118762541 http://journals.sagepub.com/doi/pdf/10.1177/1474515118762541 http://journals.sagepub.com/doi/full-xml/10.1177/1474515118762541 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_source |
European Journal of Cardiovascular Nursing volume 17, issue 6, page 563-570 ISSN 1474-5151 1873-1953 |
op_rights |
http://journals.sagepub.com/page/policies/text-and-data-mining-license |
op_doi |
https://doi.org/10.1177/1474515118762541 |
container_title |
European Journal of Cardiovascular Nursing |
container_volume |
17 |
container_issue |
6 |
container_start_page |
563 |
op_container_end_page |
570 |
_version_ |
1802650760398241792 |