Heterosis is common and inbreeding depression absent in natural populations of Arabidopsis thaliana
Abstract The importance of genetic drift in shaping patterns of adaptive genetic variation in nature is poorly known. Genetic drift should drive partially recessive deleterious mutations to high frequency, and inter‐population crosses may therefore exhibit heterosis (increased fitness relative to in...
Published in: | Journal of Evolutionary Biology |
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Oxford University Press (OUP)
2019
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Online Access: | http://dx.doi.org/10.1111/jeb.13441 https://onlinelibrary.wiley.com/doi/pdf/10.1111/jeb.13441 https://onlinelibrary.wiley.com/doi/full-xml/10.1111/jeb.13441 https://onlinelibrary.wiley.com/doi/am-pdf/10.1111/jeb.13441 |
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croxfordunivpr:10.1111/jeb.13441 2024-09-30T14:34:48+00:00 Heterosis is common and inbreeding depression absent in natural populations of Arabidopsis thaliana Oakley, Christopher G. Lundemo, Sverre Ågren, Jon Schemske, Douglas W. Division of Environmental Biology Vetenskapsrådet 2019 http://dx.doi.org/10.1111/jeb.13441 https://onlinelibrary.wiley.com/doi/pdf/10.1111/jeb.13441 https://onlinelibrary.wiley.com/doi/full-xml/10.1111/jeb.13441 https://onlinelibrary.wiley.com/doi/am-pdf/10.1111/jeb.13441 en eng Oxford University Press (OUP) http://onlinelibrary.wiley.com/termsAndConditions#am http://onlinelibrary.wiley.com/termsAndConditions#vor Journal of Evolutionary Biology volume 32, issue 6, page 592-603 ISSN 1010-061X 1420-9101 journal-article 2019 croxfordunivpr https://doi.org/10.1111/jeb.13441 2024-09-17T04:31:11Z Abstract The importance of genetic drift in shaping patterns of adaptive genetic variation in nature is poorly known. Genetic drift should drive partially recessive deleterious mutations to high frequency, and inter‐population crosses may therefore exhibit heterosis (increased fitness relative to intra‐population crosses). Low genetic diversity and greater genetic distance between populations should increase the magnitude of heterosis. Moreover, drift and selection should remove strongly deleterious recessive alleles from individual populations, resulting in reduced inbreeding depression. To estimate heterosis, we crossed 90 independent line pairs of Arabidopsis thaliana from 15 pairs of natural populations sampled across Fennoscandia and crossed an additional 41 line pairs from a subset of four of these populations to estimate inbreeding depression. We measured lifetime fitness of crosses relative to parents in a large outdoor common garden (8,448 plants in total) in central Sweden. To examine the effects of genetic diversity and genetic distance on heterosis, we genotyped parental lines for 869 SNPs. Overall, genetic variation within populations was low (median expected heterozygosity = 0.02), and genetic differentiation was high (median F ST = 0.82). Crosses between 10 of 15 population pairs exhibited significant heterosis, with magnitudes of heterosis as high as 117%. We found no significant inbreeding depression, suggesting that the observed heterosis is due to fixation of mildly deleterious alleles within populations. Widespread and substantial heterosis indicates an important role for drift in shaping genetic variation, but there was no significant relationship between fitness of crosses relative to parents and genetic diversity or genetic distance between populations. Article in Journal/Newspaper Fennoscandia Oxford University Press Journal of Evolutionary Biology 32 6 592 603 |
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Open Polar |
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Oxford University Press |
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croxfordunivpr |
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English |
description |
Abstract The importance of genetic drift in shaping patterns of adaptive genetic variation in nature is poorly known. Genetic drift should drive partially recessive deleterious mutations to high frequency, and inter‐population crosses may therefore exhibit heterosis (increased fitness relative to intra‐population crosses). Low genetic diversity and greater genetic distance between populations should increase the magnitude of heterosis. Moreover, drift and selection should remove strongly deleterious recessive alleles from individual populations, resulting in reduced inbreeding depression. To estimate heterosis, we crossed 90 independent line pairs of Arabidopsis thaliana from 15 pairs of natural populations sampled across Fennoscandia and crossed an additional 41 line pairs from a subset of four of these populations to estimate inbreeding depression. We measured lifetime fitness of crosses relative to parents in a large outdoor common garden (8,448 plants in total) in central Sweden. To examine the effects of genetic diversity and genetic distance on heterosis, we genotyped parental lines for 869 SNPs. Overall, genetic variation within populations was low (median expected heterozygosity = 0.02), and genetic differentiation was high (median F ST = 0.82). Crosses between 10 of 15 population pairs exhibited significant heterosis, with magnitudes of heterosis as high as 117%. We found no significant inbreeding depression, suggesting that the observed heterosis is due to fixation of mildly deleterious alleles within populations. Widespread and substantial heterosis indicates an important role for drift in shaping genetic variation, but there was no significant relationship between fitness of crosses relative to parents and genetic diversity or genetic distance between populations. |
author2 |
Division of Environmental Biology Vetenskapsrådet |
format |
Article in Journal/Newspaper |
author |
Oakley, Christopher G. Lundemo, Sverre Ågren, Jon Schemske, Douglas W. |
spellingShingle |
Oakley, Christopher G. Lundemo, Sverre Ågren, Jon Schemske, Douglas W. Heterosis is common and inbreeding depression absent in natural populations of Arabidopsis thaliana |
author_facet |
Oakley, Christopher G. Lundemo, Sverre Ågren, Jon Schemske, Douglas W. |
author_sort |
Oakley, Christopher G. |
title |
Heterosis is common and inbreeding depression absent in natural populations of Arabidopsis thaliana |
title_short |
Heterosis is common and inbreeding depression absent in natural populations of Arabidopsis thaliana |
title_full |
Heterosis is common and inbreeding depression absent in natural populations of Arabidopsis thaliana |
title_fullStr |
Heterosis is common and inbreeding depression absent in natural populations of Arabidopsis thaliana |
title_full_unstemmed |
Heterosis is common and inbreeding depression absent in natural populations of Arabidopsis thaliana |
title_sort |
heterosis is common and inbreeding depression absent in natural populations of arabidopsis thaliana |
publisher |
Oxford University Press (OUP) |
publishDate |
2019 |
url |
http://dx.doi.org/10.1111/jeb.13441 https://onlinelibrary.wiley.com/doi/pdf/10.1111/jeb.13441 https://onlinelibrary.wiley.com/doi/full-xml/10.1111/jeb.13441 https://onlinelibrary.wiley.com/doi/am-pdf/10.1111/jeb.13441 |
genre |
Fennoscandia |
genre_facet |
Fennoscandia |
op_source |
Journal of Evolutionary Biology volume 32, issue 6, page 592-603 ISSN 1010-061X 1420-9101 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#am http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/jeb.13441 |
container_title |
Journal of Evolutionary Biology |
container_volume |
32 |
container_issue |
6 |
container_start_page |
592 |
op_container_end_page |
603 |
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1811638301005709312 |