The interplay between sleeplessness and high-sensitivity C-reactive protein on risk of chronic musculoskeletal pain: longitudinal data from the Tromsø Study
Abstract Study Objectives To examine independent associations of sleeplessness and high-sensitivity C-reactive protein (hsCRP) with risk of chronic musculoskeletal pain, and to explore the joint effect of sleeplessness and hsCRP on risk of chronic musculoskeletal pain. Methods A population-based pro...
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Oxford University Press (OUP)
2019
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Online Access: | http://dx.doi.org/10.1093/sleep/zsz127 http://academic.oup.com/sleep/advance-article-pdf/doi/10.1093/sleep/zsz127/28836336/zsz127.pdf http://academic.oup.com/sleep/article-pdf/42/9/zsz127/29807375/zsz127.pdf |
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croxfordunivpr:10.1093/sleep/zsz127 2024-09-15T18:39:28+00:00 The interplay between sleeplessness and high-sensitivity C-reactive protein on risk of chronic musculoskeletal pain: longitudinal data from the Tromsø Study Skarpsno, Eivind Schjelderup Mork, Paul Jarle Nilsen, Tom Ivar Lund Steingrímsdóttir, Ólöf Anna Zwart, John Anker Nilsen, Kristian Bernhard Norway Regional Health Authority Norwegian University of Science and Technology 2019 http://dx.doi.org/10.1093/sleep/zsz127 http://academic.oup.com/sleep/advance-article-pdf/doi/10.1093/sleep/zsz127/28836336/zsz127.pdf http://academic.oup.com/sleep/article-pdf/42/9/zsz127/29807375/zsz127.pdf en eng Oxford University Press (OUP) https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model Sleep volume 42, issue 9 ISSN 0161-8105 1550-9109 journal-article 2019 croxfordunivpr https://doi.org/10.1093/sleep/zsz127 2024-08-27T04:16:13Z Abstract Study Objectives To examine independent associations of sleeplessness and high-sensitivity C-reactive protein (hsCRP) with risk of chronic musculoskeletal pain, and to explore the joint effect of sleeplessness and hsCRP on risk of chronic musculoskeletal pain. Methods A population-based prospective study of 3214 women and 3142 men (mean age: 55.4, range: 32–87) without severe chronic musculoskeletal pain and with hsCRP ≤ 10 mg/L at baseline in 2007–2008. Modified Poisson regression was used to calculate adjusted risk ratios (RRs) with 95% confidence intervals (CIs) for any chronic musculoskeletal pain and chronic widespread pain (CWP) at follow-up in 2015–2016 associated with self-reported sleeplessness and hsCRP at baseline. Results Compared with persons without sleeplessness, women and men reporting often/or always sleeplessness had RRs of CWP of 2.53 (95% CI: 1.94–3.29) and 2.48 (95% CI: 1.63–3.77), respectively. There was no clear association between hsCRP and risk of any chronic musculoskeletal pain or CWP. Joint effect analyses using persons without sleeplessness and with a hsCRP < 1.00 mg/L as the reference gave RRs for chronic musculoskeletal pain of 1.73 (95% CI: 1.26–2.37) for those with often/always sleeplessness and hsCRP < 1.00 mg/L; 1.01 (95% CI: 0.78–1.32) for those without sleeplessness and hsCRP ≥3.00 mg/L; and 2.47 (95% CI: 1.79–3.40) if they had both often/always sleeplessness and hsCRP ≥ 3.00 mg/L. The corresponding RRs for CWP were 1.89 (95% CI: 1.27–2.83), 0.96 (95% CI: 0.68–1.37), and 2.83 (95% CI: 1.91–4.20), respectively. Conclusions These results suggest that there is an interplay between sleeplessness and hsCRP on risk of any chronic musculoskeletal pain and CWP. Article in Journal/Newspaper Tromsø Oxford University Press Sleep 42 9 |
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Open Polar |
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Oxford University Press |
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croxfordunivpr |
language |
English |
description |
Abstract Study Objectives To examine independent associations of sleeplessness and high-sensitivity C-reactive protein (hsCRP) with risk of chronic musculoskeletal pain, and to explore the joint effect of sleeplessness and hsCRP on risk of chronic musculoskeletal pain. Methods A population-based prospective study of 3214 women and 3142 men (mean age: 55.4, range: 32–87) without severe chronic musculoskeletal pain and with hsCRP ≤ 10 mg/L at baseline in 2007–2008. Modified Poisson regression was used to calculate adjusted risk ratios (RRs) with 95% confidence intervals (CIs) for any chronic musculoskeletal pain and chronic widespread pain (CWP) at follow-up in 2015–2016 associated with self-reported sleeplessness and hsCRP at baseline. Results Compared with persons without sleeplessness, women and men reporting often/or always sleeplessness had RRs of CWP of 2.53 (95% CI: 1.94–3.29) and 2.48 (95% CI: 1.63–3.77), respectively. There was no clear association between hsCRP and risk of any chronic musculoskeletal pain or CWP. Joint effect analyses using persons without sleeplessness and with a hsCRP < 1.00 mg/L as the reference gave RRs for chronic musculoskeletal pain of 1.73 (95% CI: 1.26–2.37) for those with often/always sleeplessness and hsCRP < 1.00 mg/L; 1.01 (95% CI: 0.78–1.32) for those without sleeplessness and hsCRP ≥3.00 mg/L; and 2.47 (95% CI: 1.79–3.40) if they had both often/always sleeplessness and hsCRP ≥ 3.00 mg/L. The corresponding RRs for CWP were 1.89 (95% CI: 1.27–2.83), 0.96 (95% CI: 0.68–1.37), and 2.83 (95% CI: 1.91–4.20), respectively. Conclusions These results suggest that there is an interplay between sleeplessness and hsCRP on risk of any chronic musculoskeletal pain and CWP. |
author2 |
Norway Regional Health Authority Norwegian University of Science and Technology |
format |
Article in Journal/Newspaper |
author |
Skarpsno, Eivind Schjelderup Mork, Paul Jarle Nilsen, Tom Ivar Lund Steingrímsdóttir, Ólöf Anna Zwart, John Anker Nilsen, Kristian Bernhard |
spellingShingle |
Skarpsno, Eivind Schjelderup Mork, Paul Jarle Nilsen, Tom Ivar Lund Steingrímsdóttir, Ólöf Anna Zwart, John Anker Nilsen, Kristian Bernhard The interplay between sleeplessness and high-sensitivity C-reactive protein on risk of chronic musculoskeletal pain: longitudinal data from the Tromsø Study |
author_facet |
Skarpsno, Eivind Schjelderup Mork, Paul Jarle Nilsen, Tom Ivar Lund Steingrímsdóttir, Ólöf Anna Zwart, John Anker Nilsen, Kristian Bernhard |
author_sort |
Skarpsno, Eivind Schjelderup |
title |
The interplay between sleeplessness and high-sensitivity C-reactive protein on risk of chronic musculoskeletal pain: longitudinal data from the Tromsø Study |
title_short |
The interplay between sleeplessness and high-sensitivity C-reactive protein on risk of chronic musculoskeletal pain: longitudinal data from the Tromsø Study |
title_full |
The interplay between sleeplessness and high-sensitivity C-reactive protein on risk of chronic musculoskeletal pain: longitudinal data from the Tromsø Study |
title_fullStr |
The interplay between sleeplessness and high-sensitivity C-reactive protein on risk of chronic musculoskeletal pain: longitudinal data from the Tromsø Study |
title_full_unstemmed |
The interplay between sleeplessness and high-sensitivity C-reactive protein on risk of chronic musculoskeletal pain: longitudinal data from the Tromsø Study |
title_sort |
interplay between sleeplessness and high-sensitivity c-reactive protein on risk of chronic musculoskeletal pain: longitudinal data from the tromsø study |
publisher |
Oxford University Press (OUP) |
publishDate |
2019 |
url |
http://dx.doi.org/10.1093/sleep/zsz127 http://academic.oup.com/sleep/advance-article-pdf/doi/10.1093/sleep/zsz127/28836336/zsz127.pdf http://academic.oup.com/sleep/article-pdf/42/9/zsz127/29807375/zsz127.pdf |
genre |
Tromsø |
genre_facet |
Tromsø |
op_source |
Sleep volume 42, issue 9 ISSN 0161-8105 1550-9109 |
op_rights |
https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model |
op_doi |
https://doi.org/10.1093/sleep/zsz127 |
container_title |
Sleep |
container_volume |
42 |
container_issue |
9 |
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1810483836467806208 |