Increasing incidence and prevalence of ANCA-associated vasculitis in Northern Norway
Abstract Objective ANCA-associated vasculitides (AAV) have increased in prevalence since the 1980s. We aimed to investigate the incidence and prevalence of AAV during a 15-year period from 1999 to 2013 in Northern Norway, looking for variations during this period. Methods Patient records were retrie...
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croxfordunivpr:10.1093/rheumatology/kez597 2024-06-23T07:55:33+00:00 Increasing incidence and prevalence of ANCA-associated vasculitis in Northern Norway Nilsen, Aksel Thuv Karlsen, Christine Bakland, Gunnstein Watts, Richard Luqmani, Raashid Koldingsnes, Wenche Northern Norway Regional Health Authority 2019 http://dx.doi.org/10.1093/rheumatology/kez597 http://academic.oup.com/rheumatology/article-pdf/59/9/2316/33686367/kez597.pdf en eng Oxford University Press (OUP) https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model Rheumatology volume 59, issue 9, page 2316-2324 ISSN 1462-0324 1462-0332 journal-article 2019 croxfordunivpr https://doi.org/10.1093/rheumatology/kez597 2024-06-11T04:22:30Z Abstract Objective ANCA-associated vasculitides (AAV) have increased in prevalence since the 1980s. We aimed to investigate the incidence and prevalence of AAV during a 15-year period from 1999 to 2013 in Northern Norway, looking for variations during this period. Methods Patient records were retrieved from The Northern Norwegian Vasculitis Registry; in addition we searched all regional hospital databases. Patients diagnosed with AAV from 1999 through to 2013 were included. For prevalence data, patients residing in the area, but with AAV diagnosis prior to 1999, were also included. The diagnosis of AAV was based on the European Medicines Agency algorithm. Results We identified 140 cases; 88 were classified as granulomatosis with polyangiitis (GPA), 37 as microscopic polyangiitis (MPA) and 15 as eosinophilic granulomatosis with polyangiitis (EGPA). Adult (age ≥15 years) annual incidence rates per million were as follows: for GPA 15.6 (95% CI: 12.5, 19.2), MPA 6.5 (95% CI: 4.6, 9.0), EGPA 2.7 (95% CI: 1.5, 4.5) and overall AAV 24.7 (95% CI: 20.8, 29.2). Incidences of MPA and overall AAV showed an increasing trend (P < 0.05). Adult point prevalence rates per million in 2013 were 261 (95% CI: 213, 316) for GPA, 58.2 (95% CI: 36.9, 87.3) for MPA, 32.9 (95% CI: 17.5, 56.3) for EGPA and 351 (95% CI: 296, 416) for overall AAV. Conclusion The incidence rate of GPA and the prevalence rates of GPA and EGPA are currently the highest reported. MPA increased significantly from a prior low incidence. The overall AAV annual incidence and prevalence are still increasing. Article in Journal/Newspaper Northern Norway Oxford University Press Norway Rheumatology 59 9 2316 2324 |
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Oxford University Press |
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description |
Abstract Objective ANCA-associated vasculitides (AAV) have increased in prevalence since the 1980s. We aimed to investigate the incidence and prevalence of AAV during a 15-year period from 1999 to 2013 in Northern Norway, looking for variations during this period. Methods Patient records were retrieved from The Northern Norwegian Vasculitis Registry; in addition we searched all regional hospital databases. Patients diagnosed with AAV from 1999 through to 2013 were included. For prevalence data, patients residing in the area, but with AAV diagnosis prior to 1999, were also included. The diagnosis of AAV was based on the European Medicines Agency algorithm. Results We identified 140 cases; 88 were classified as granulomatosis with polyangiitis (GPA), 37 as microscopic polyangiitis (MPA) and 15 as eosinophilic granulomatosis with polyangiitis (EGPA). Adult (age ≥15 years) annual incidence rates per million were as follows: for GPA 15.6 (95% CI: 12.5, 19.2), MPA 6.5 (95% CI: 4.6, 9.0), EGPA 2.7 (95% CI: 1.5, 4.5) and overall AAV 24.7 (95% CI: 20.8, 29.2). Incidences of MPA and overall AAV showed an increasing trend (P < 0.05). Adult point prevalence rates per million in 2013 were 261 (95% CI: 213, 316) for GPA, 58.2 (95% CI: 36.9, 87.3) for MPA, 32.9 (95% CI: 17.5, 56.3) for EGPA and 351 (95% CI: 296, 416) for overall AAV. Conclusion The incidence rate of GPA and the prevalence rates of GPA and EGPA are currently the highest reported. MPA increased significantly from a prior low incidence. The overall AAV annual incidence and prevalence are still increasing. |
author2 |
Northern Norway Regional Health Authority |
format |
Article in Journal/Newspaper |
author |
Nilsen, Aksel Thuv Karlsen, Christine Bakland, Gunnstein Watts, Richard Luqmani, Raashid Koldingsnes, Wenche |
spellingShingle |
Nilsen, Aksel Thuv Karlsen, Christine Bakland, Gunnstein Watts, Richard Luqmani, Raashid Koldingsnes, Wenche Increasing incidence and prevalence of ANCA-associated vasculitis in Northern Norway |
author_facet |
Nilsen, Aksel Thuv Karlsen, Christine Bakland, Gunnstein Watts, Richard Luqmani, Raashid Koldingsnes, Wenche |
author_sort |
Nilsen, Aksel Thuv |
title |
Increasing incidence and prevalence of ANCA-associated vasculitis in Northern Norway |
title_short |
Increasing incidence and prevalence of ANCA-associated vasculitis in Northern Norway |
title_full |
Increasing incidence and prevalence of ANCA-associated vasculitis in Northern Norway |
title_fullStr |
Increasing incidence and prevalence of ANCA-associated vasculitis in Northern Norway |
title_full_unstemmed |
Increasing incidence and prevalence of ANCA-associated vasculitis in Northern Norway |
title_sort |
increasing incidence and prevalence of anca-associated vasculitis in northern norway |
publisher |
Oxford University Press (OUP) |
publishDate |
2019 |
url |
http://dx.doi.org/10.1093/rheumatology/kez597 http://academic.oup.com/rheumatology/article-pdf/59/9/2316/33686367/kez597.pdf |
geographic |
Norway |
geographic_facet |
Norway |
genre |
Northern Norway |
genre_facet |
Northern Norway |
op_source |
Rheumatology volume 59, issue 9, page 2316-2324 ISSN 1462-0324 1462-0332 |
op_rights |
https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model |
op_doi |
https://doi.org/10.1093/rheumatology/kez597 |
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Rheumatology |
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59 |
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9 |
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2316 |
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2324 |
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1802648189252141056 |