Cross-species recognition and molecular basis of SARS-CoV-2 and SARS-CoV binding to ACE2s of marine animals
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has an extremely broad host range that includes hippopotami, which are phylogenetically closely related to whales. The cellular ACE2 receptor is one of the key determinants of the host range. Here, we found that ACE2s from several...
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Oxford University Press (OUP)
2022
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Online Access: | http://dx.doi.org/10.1093/nsr/nwac122 https://academic.oup.com/nsr/advance-article-pdf/doi/10.1093/nsr/nwac122/44235330/nwac122.pdf https://academic.oup.com/nsr/article-pdf/9/9/nwac122/46120193/nwac122.pdf |
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croxfordunivpr:10.1093/nsr/nwac122 2024-09-30T14:38:34+00:00 Cross-species recognition and molecular basis of SARS-CoV-2 and SARS-CoV binding to ACE2s of marine animals Li, Shihua Yang, Ruirui Zhang, Di Han, Pu Xu, Zepeng Chen, Qian Zhao, Runchu Zhao, Xin Qu, Xiao Zheng, Anqi Wang, Liang Li, Linjie Hu, Yu Zhang, Rong Su, Chao Niu, Sheng Zhang, Yanfang Qi, Jianxun Liu, Kefang Wang, Qihui Gao, George F Chinese Academy of Sciences National Key Research and Development of China National Natural Science Foundation of China Youth Innovation Promotion Association CAS 2022 http://dx.doi.org/10.1093/nsr/nwac122 https://academic.oup.com/nsr/advance-article-pdf/doi/10.1093/nsr/nwac122/44235330/nwac122.pdf https://academic.oup.com/nsr/article-pdf/9/9/nwac122/46120193/nwac122.pdf en eng Oxford University Press (OUP) https://creativecommons.org/licenses/by/4.0/ National Science Review volume 9, issue 9 ISSN 2095-5138 2053-714X journal-article 2022 croxfordunivpr https://doi.org/10.1093/nsr/nwac122 2024-09-17T04:27:20Z Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has an extremely broad host range that includes hippopotami, which are phylogenetically closely related to whales. The cellular ACE2 receptor is one of the key determinants of the host range. Here, we found that ACE2s from several marine mammals and hippopotami could efficiently bind to the receptor-binding domain (RBD) of both SARS-CoV and SARS-CoV-2 and facilitate the transduction of SARS-CoV and SARS-CoV-2 pseudoviruses into ACE2-expressing cells. We further resolved the cryo-electron microscopy complex structures of the minke whale ACE2 and sea lion ACE2, respectively, bound to the RBDs, revealing that they have similar binding modes to human ACE2 when it comes to the SARS-CoV-2 RBD and SARS-CoV RBD. Our results indicate that marine mammals could potentially be new victims or virus carriers of SARS-CoV-2, which deserves further careful investigation and study. It will provide an early warning for the prospective monitoring of marine mammals. Article in Journal/Newspaper minke whale Oxford University Press National Science Review |
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Open Polar |
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Oxford University Press |
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croxfordunivpr |
language |
English |
description |
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has an extremely broad host range that includes hippopotami, which are phylogenetically closely related to whales. The cellular ACE2 receptor is one of the key determinants of the host range. Here, we found that ACE2s from several marine mammals and hippopotami could efficiently bind to the receptor-binding domain (RBD) of both SARS-CoV and SARS-CoV-2 and facilitate the transduction of SARS-CoV and SARS-CoV-2 pseudoviruses into ACE2-expressing cells. We further resolved the cryo-electron microscopy complex structures of the minke whale ACE2 and sea lion ACE2, respectively, bound to the RBDs, revealing that they have similar binding modes to human ACE2 when it comes to the SARS-CoV-2 RBD and SARS-CoV RBD. Our results indicate that marine mammals could potentially be new victims or virus carriers of SARS-CoV-2, which deserves further careful investigation and study. It will provide an early warning for the prospective monitoring of marine mammals. |
author2 |
Chinese Academy of Sciences National Key Research and Development of China National Natural Science Foundation of China Youth Innovation Promotion Association CAS |
format |
Article in Journal/Newspaper |
author |
Li, Shihua Yang, Ruirui Zhang, Di Han, Pu Xu, Zepeng Chen, Qian Zhao, Runchu Zhao, Xin Qu, Xiao Zheng, Anqi Wang, Liang Li, Linjie Hu, Yu Zhang, Rong Su, Chao Niu, Sheng Zhang, Yanfang Qi, Jianxun Liu, Kefang Wang, Qihui Gao, George F |
spellingShingle |
Li, Shihua Yang, Ruirui Zhang, Di Han, Pu Xu, Zepeng Chen, Qian Zhao, Runchu Zhao, Xin Qu, Xiao Zheng, Anqi Wang, Liang Li, Linjie Hu, Yu Zhang, Rong Su, Chao Niu, Sheng Zhang, Yanfang Qi, Jianxun Liu, Kefang Wang, Qihui Gao, George F Cross-species recognition and molecular basis of SARS-CoV-2 and SARS-CoV binding to ACE2s of marine animals |
author_facet |
Li, Shihua Yang, Ruirui Zhang, Di Han, Pu Xu, Zepeng Chen, Qian Zhao, Runchu Zhao, Xin Qu, Xiao Zheng, Anqi Wang, Liang Li, Linjie Hu, Yu Zhang, Rong Su, Chao Niu, Sheng Zhang, Yanfang Qi, Jianxun Liu, Kefang Wang, Qihui Gao, George F |
author_sort |
Li, Shihua |
title |
Cross-species recognition and molecular basis of SARS-CoV-2 and SARS-CoV binding to ACE2s of marine animals |
title_short |
Cross-species recognition and molecular basis of SARS-CoV-2 and SARS-CoV binding to ACE2s of marine animals |
title_full |
Cross-species recognition and molecular basis of SARS-CoV-2 and SARS-CoV binding to ACE2s of marine animals |
title_fullStr |
Cross-species recognition and molecular basis of SARS-CoV-2 and SARS-CoV binding to ACE2s of marine animals |
title_full_unstemmed |
Cross-species recognition and molecular basis of SARS-CoV-2 and SARS-CoV binding to ACE2s of marine animals |
title_sort |
cross-species recognition and molecular basis of sars-cov-2 and sars-cov binding to ace2s of marine animals |
publisher |
Oxford University Press (OUP) |
publishDate |
2022 |
url |
http://dx.doi.org/10.1093/nsr/nwac122 https://academic.oup.com/nsr/advance-article-pdf/doi/10.1093/nsr/nwac122/44235330/nwac122.pdf https://academic.oup.com/nsr/article-pdf/9/9/nwac122/46120193/nwac122.pdf |
genre |
minke whale |
genre_facet |
minke whale |
op_source |
National Science Review volume 9, issue 9 ISSN 2095-5138 2053-714X |
op_rights |
https://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.1093/nsr/nwac122 |
container_title |
National Science Review |
_version_ |
1811641196130336768 |