Evidence of Pathogen-Induced Immunogenetic Selection across the Large Geographic Range of a Wild Seabird
Abstract Over evolutionary time, pathogen challenge shapes the immune phenotype of the host to better respond to an incipient threat. The extent and direction of this selection pressure depend on the local pathogen composition, which is in turn determined by biotic and abiotic features of the enviro...
Published in: | Molecular Biology and Evolution |
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Oxford University Press (OUP)
2020
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Online Access: | http://dx.doi.org/10.1093/molbev/msaa040 http://academic.oup.com/mbe/advance-article-pdf/doi/10.1093/molbev/msaa040/32931989/msaa040.pdf http://academic.oup.com/mbe/article-pdf/37/6/1708/33317007/msaa040.pdf |
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croxfordunivpr:10.1093/molbev/msaa040 2024-06-09T07:46:06+00:00 Evidence of Pathogen-Induced Immunogenetic Selection across the Large Geographic Range of a Wild Seabird Levy, Hila Fiddaman, Steven R Vianna, Juliana A Noll, Daly Clucas, Gemma V Sidhu, Jasmine K H Polito, Michael J Bost, Charles A Phillips, Richard A Crofts, Sarah Miller, Gary D Pistorius, Pierre Bonnadonna, Francesco Le Bohec, Céline Barbosa, Andrés Trathan, Phil Raya Rey, Andrea Frantz, Laurent A F Hart, Tom Smith, Adrian L Yeager, Meredith Oxford Clarendon Fund Biotechnology and Biological Sciences Research Council BBSRC CONICYT PIA Spanish Ministry of Science Institut Polaire Français Paul-Emile Victor Laboratoire International Associé 647 “BioSensib” CSM/CNRS-University of Strasbourg 2020 http://dx.doi.org/10.1093/molbev/msaa040 http://academic.oup.com/mbe/advance-article-pdf/doi/10.1093/molbev/msaa040/32931989/msaa040.pdf http://academic.oup.com/mbe/article-pdf/37/6/1708/33317007/msaa040.pdf en eng Oxford University Press (OUP) http://creativecommons.org/licenses/by/4.0/ Molecular Biology and Evolution volume 37, issue 6, page 1708-1726 ISSN 0737-4038 1537-1719 journal-article 2020 croxfordunivpr https://doi.org/10.1093/molbev/msaa040 2024-05-10T13:14:33Z Abstract Over evolutionary time, pathogen challenge shapes the immune phenotype of the host to better respond to an incipient threat. The extent and direction of this selection pressure depend on the local pathogen composition, which is in turn determined by biotic and abiotic features of the environment. However, little is known about adaptation to local pathogen threats in wild animals. The Gentoo penguin (Pygoscelis papua) is a species complex that lends itself to the study of immune adaptation because of its circumpolar distribution over a large latitudinal range, with little or no admixture between different clades. In this study, we examine the diversity in a key family of innate immune genes—the Toll-like receptors (TLRs)—across the range of the Gentoo penguin. The three TLRs that we investigated present varying levels of diversity, with TLR4 and TLR5 greatly exceeding the diversity of TLR7. We present evidence of positive selection in TLR4 and TLR5, which points to pathogen-driven adaptation to the local pathogen milieu. Finally, we demonstrate that two positively selected cosegregating sites in TLR5 are sufficient to alter the responsiveness of the receptor to its bacterial ligand, flagellin. Taken together, these results suggest that Gentoo penguins have experienced distinct pathogen-driven selection pressures in different environments, which may be important given the role of the Gentoo penguin as a sentinel species in some of the world’s most rapidly changing environments. Article in Journal/Newspaper Gentoo penguin Pygoscelis papua Oxford University Press Molecular Biology and Evolution 37 6 1708 1726 |
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Oxford University Press |
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croxfordunivpr |
language |
English |
description |
Abstract Over evolutionary time, pathogen challenge shapes the immune phenotype of the host to better respond to an incipient threat. The extent and direction of this selection pressure depend on the local pathogen composition, which is in turn determined by biotic and abiotic features of the environment. However, little is known about adaptation to local pathogen threats in wild animals. The Gentoo penguin (Pygoscelis papua) is a species complex that lends itself to the study of immune adaptation because of its circumpolar distribution over a large latitudinal range, with little or no admixture between different clades. In this study, we examine the diversity in a key family of innate immune genes—the Toll-like receptors (TLRs)—across the range of the Gentoo penguin. The three TLRs that we investigated present varying levels of diversity, with TLR4 and TLR5 greatly exceeding the diversity of TLR7. We present evidence of positive selection in TLR4 and TLR5, which points to pathogen-driven adaptation to the local pathogen milieu. Finally, we demonstrate that two positively selected cosegregating sites in TLR5 are sufficient to alter the responsiveness of the receptor to its bacterial ligand, flagellin. Taken together, these results suggest that Gentoo penguins have experienced distinct pathogen-driven selection pressures in different environments, which may be important given the role of the Gentoo penguin as a sentinel species in some of the world’s most rapidly changing environments. |
author2 |
Yeager, Meredith Oxford Clarendon Fund Biotechnology and Biological Sciences Research Council BBSRC CONICYT PIA Spanish Ministry of Science Institut Polaire Français Paul-Emile Victor Laboratoire International Associé 647 “BioSensib” CSM/CNRS-University of Strasbourg |
format |
Article in Journal/Newspaper |
author |
Levy, Hila Fiddaman, Steven R Vianna, Juliana A Noll, Daly Clucas, Gemma V Sidhu, Jasmine K H Polito, Michael J Bost, Charles A Phillips, Richard A Crofts, Sarah Miller, Gary D Pistorius, Pierre Bonnadonna, Francesco Le Bohec, Céline Barbosa, Andrés Trathan, Phil Raya Rey, Andrea Frantz, Laurent A F Hart, Tom Smith, Adrian L |
spellingShingle |
Levy, Hila Fiddaman, Steven R Vianna, Juliana A Noll, Daly Clucas, Gemma V Sidhu, Jasmine K H Polito, Michael J Bost, Charles A Phillips, Richard A Crofts, Sarah Miller, Gary D Pistorius, Pierre Bonnadonna, Francesco Le Bohec, Céline Barbosa, Andrés Trathan, Phil Raya Rey, Andrea Frantz, Laurent A F Hart, Tom Smith, Adrian L Evidence of Pathogen-Induced Immunogenetic Selection across the Large Geographic Range of a Wild Seabird |
author_facet |
Levy, Hila Fiddaman, Steven R Vianna, Juliana A Noll, Daly Clucas, Gemma V Sidhu, Jasmine K H Polito, Michael J Bost, Charles A Phillips, Richard A Crofts, Sarah Miller, Gary D Pistorius, Pierre Bonnadonna, Francesco Le Bohec, Céline Barbosa, Andrés Trathan, Phil Raya Rey, Andrea Frantz, Laurent A F Hart, Tom Smith, Adrian L |
author_sort |
Levy, Hila |
title |
Evidence of Pathogen-Induced Immunogenetic Selection across the Large Geographic Range of a Wild Seabird |
title_short |
Evidence of Pathogen-Induced Immunogenetic Selection across the Large Geographic Range of a Wild Seabird |
title_full |
Evidence of Pathogen-Induced Immunogenetic Selection across the Large Geographic Range of a Wild Seabird |
title_fullStr |
Evidence of Pathogen-Induced Immunogenetic Selection across the Large Geographic Range of a Wild Seabird |
title_full_unstemmed |
Evidence of Pathogen-Induced Immunogenetic Selection across the Large Geographic Range of a Wild Seabird |
title_sort |
evidence of pathogen-induced immunogenetic selection across the large geographic range of a wild seabird |
publisher |
Oxford University Press (OUP) |
publishDate |
2020 |
url |
http://dx.doi.org/10.1093/molbev/msaa040 http://academic.oup.com/mbe/advance-article-pdf/doi/10.1093/molbev/msaa040/32931989/msaa040.pdf http://academic.oup.com/mbe/article-pdf/37/6/1708/33317007/msaa040.pdf |
genre |
Gentoo penguin Pygoscelis papua |
genre_facet |
Gentoo penguin Pygoscelis papua |
op_source |
Molecular Biology and Evolution volume 37, issue 6, page 1708-1726 ISSN 0737-4038 1537-1719 |
op_rights |
http://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.1093/molbev/msaa040 |
container_title |
Molecular Biology and Evolution |
container_volume |
37 |
container_issue |
6 |
container_start_page |
1708 |
op_container_end_page |
1726 |
_version_ |
1801375856019374080 |