Genome-Wide Association Study of Piscine Myocarditis Virus (PMCV) Resistance in Atlantic Salmon (Salmo salar)
Abstract Cardiomyopathy syndrome is a severe, viral disease of Atlantic salmon that mostly affects farmed animals during their late production stage at sea. Caused by piscine myocarditis virus (PMCV), over the past few years outbreaks due to this disease have resulted in significant losses to the aq...
Published in: | Journal of Heredity |
---|---|
Main Authors: | , |
Other Authors: | |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Oxford University Press (OUP)
2019
|
Subjects: | |
Online Access: | http://dx.doi.org/10.1093/jhered/esz040 http://academic.oup.com/jhered/advance-article-pdf/doi/10.1093/jhered/esz040/28944209/esz040.pdf http://academic.oup.com/jhered/article-pdf/110/6/720/30131839/esz040.pdf |
id |
croxfordunivpr:10.1093/jhered/esz040 |
---|---|
record_format |
openpolar |
spelling |
croxfordunivpr:10.1093/jhered/esz040 2024-05-19T07:37:41+00:00 Genome-Wide Association Study of Piscine Myocarditis Virus (PMCV) Resistance in Atlantic Salmon (Salmo salar) Hillestad, Borghild Moghadam, Hooman K Reed, Floyd 2019 http://dx.doi.org/10.1093/jhered/esz040 http://academic.oup.com/jhered/advance-article-pdf/doi/10.1093/jhered/esz040/28944209/esz040.pdf http://academic.oup.com/jhered/article-pdf/110/6/720/30131839/esz040.pdf en eng Oxford University Press (OUP) https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model Journal of Heredity volume 110, issue 6, page 720-726 ISSN 0022-1503 1465-7333 journal-article 2019 croxfordunivpr https://doi.org/10.1093/jhered/esz040 2024-05-02T09:32:44Z Abstract Cardiomyopathy syndrome is a severe, viral disease of Atlantic salmon that mostly affects farmed animals during their late production stage at sea. Caused by piscine myocarditis virus (PMCV), over the past few years outbreaks due to this disease have resulted in significant losses to the aquaculture industry. However, there is currently no vaccine that has proven effective against this virus. In this study, using a challenge model, we investigated the genetic variation for resistance to PMCV, by screening a large number of animals using a 55 K SNP array. In particular, we aimed to identify genetic markers that are tightly linked to higher disease resistance and can potentially be used in breeding programs. Using genomic information, we estimated a heritability of 0.51 ± 0.06, suggesting that resistance against this virus, to a great extent, is controlled by genetic factors. Through association analysis, we identified a significant quantitative trait locus (QTL) on chromosome 27, explaining approximately 57% of the total additive genetic variation. The region harboring this QTL contains various immune-related candidate genes, many of which have previously been shown to have a different expression profile between the naïve and infected animals. We also identified a suggestive association on chromosome 12, with the QTL linked markers located in 2 putatively immune-related genes. These results are of particular interest, as they can readily be implemented into breeding programs, can further assist in fine-mapping the causative mutations, and help in better understanding the biology of the disease and the immunological mechanisms underlying resistance against PMCV. Article in Journal/Newspaper Atlantic salmon Salmo salar Oxford University Press Journal of Heredity 110 6 720 726 |
institution |
Open Polar |
collection |
Oxford University Press |
op_collection_id |
croxfordunivpr |
language |
English |
description |
Abstract Cardiomyopathy syndrome is a severe, viral disease of Atlantic salmon that mostly affects farmed animals during their late production stage at sea. Caused by piscine myocarditis virus (PMCV), over the past few years outbreaks due to this disease have resulted in significant losses to the aquaculture industry. However, there is currently no vaccine that has proven effective against this virus. In this study, using a challenge model, we investigated the genetic variation for resistance to PMCV, by screening a large number of animals using a 55 K SNP array. In particular, we aimed to identify genetic markers that are tightly linked to higher disease resistance and can potentially be used in breeding programs. Using genomic information, we estimated a heritability of 0.51 ± 0.06, suggesting that resistance against this virus, to a great extent, is controlled by genetic factors. Through association analysis, we identified a significant quantitative trait locus (QTL) on chromosome 27, explaining approximately 57% of the total additive genetic variation. The region harboring this QTL contains various immune-related candidate genes, many of which have previously been shown to have a different expression profile between the naïve and infected animals. We also identified a suggestive association on chromosome 12, with the QTL linked markers located in 2 putatively immune-related genes. These results are of particular interest, as they can readily be implemented into breeding programs, can further assist in fine-mapping the causative mutations, and help in better understanding the biology of the disease and the immunological mechanisms underlying resistance against PMCV. |
author2 |
Reed, Floyd |
format |
Article in Journal/Newspaper |
author |
Hillestad, Borghild Moghadam, Hooman K |
spellingShingle |
Hillestad, Borghild Moghadam, Hooman K Genome-Wide Association Study of Piscine Myocarditis Virus (PMCV) Resistance in Atlantic Salmon (Salmo salar) |
author_facet |
Hillestad, Borghild Moghadam, Hooman K |
author_sort |
Hillestad, Borghild |
title |
Genome-Wide Association Study of Piscine Myocarditis Virus (PMCV) Resistance in Atlantic Salmon (Salmo salar) |
title_short |
Genome-Wide Association Study of Piscine Myocarditis Virus (PMCV) Resistance in Atlantic Salmon (Salmo salar) |
title_full |
Genome-Wide Association Study of Piscine Myocarditis Virus (PMCV) Resistance in Atlantic Salmon (Salmo salar) |
title_fullStr |
Genome-Wide Association Study of Piscine Myocarditis Virus (PMCV) Resistance in Atlantic Salmon (Salmo salar) |
title_full_unstemmed |
Genome-Wide Association Study of Piscine Myocarditis Virus (PMCV) Resistance in Atlantic Salmon (Salmo salar) |
title_sort |
genome-wide association study of piscine myocarditis virus (pmcv) resistance in atlantic salmon (salmo salar) |
publisher |
Oxford University Press (OUP) |
publishDate |
2019 |
url |
http://dx.doi.org/10.1093/jhered/esz040 http://academic.oup.com/jhered/advance-article-pdf/doi/10.1093/jhered/esz040/28944209/esz040.pdf http://academic.oup.com/jhered/article-pdf/110/6/720/30131839/esz040.pdf |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_source |
Journal of Heredity volume 110, issue 6, page 720-726 ISSN 0022-1503 1465-7333 |
op_rights |
https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model |
op_doi |
https://doi.org/10.1093/jhered/esz040 |
container_title |
Journal of Heredity |
container_volume |
110 |
container_issue |
6 |
container_start_page |
720 |
op_container_end_page |
726 |
_version_ |
1799477033824157696 |