Estimating Lactase Nonpersistence Distributions in the Multi-Ethnic Canadian Demographic: A Population-Based Study
Abstract Objectives The lactase persistence/nonpersistence (LP/LNP) phenotypes follow a geographic pattern that is rooted in the gene-culture coevolution observed throughout the history of human migrations. The immense size and relatively open immigration policy have drawn migrants of diverse ethnic...
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Online Access: | http://dx.doi.org/10.1093/jcag/gwy068 http://academic.oup.com/jcag/article-pdf/3/3/103/33182423/gwy068.pdf |
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croxfordunivpr:10.1093/jcag/gwy068 2024-09-15T18:26:39+00:00 Estimating Lactase Nonpersistence Distributions in the Multi-Ethnic Canadian Demographic: A Population-Based Study Fung, Manyan Xue, Xiaoqing Szilagyi, Andrew 2018 http://dx.doi.org/10.1093/jcag/gwy068 http://academic.oup.com/jcag/article-pdf/3/3/103/33182423/gwy068.pdf en eng Oxford University Press (OUP) http://creativecommons.org/licenses/by-nc/4.0/ Journal of the Canadian Association of Gastroenterology volume 3, issue 3, page 103-110 ISSN 2515-2084 2515-2092 journal-article 2018 croxfordunivpr https://doi.org/10.1093/jcag/gwy068 2024-07-15T04:25:11Z Abstract Objectives The lactase persistence/nonpersistence (LP/LNP) phenotypes follow a geographic pattern that is rooted in the gene-culture coevolution observed throughout the history of human migrations. The immense size and relatively open immigration policy have drawn migrants of diverse ethnicities to Canada. Among the multicultural demographic, two-thirds of the population are derived from the British Isles and northwestern France. A recent assessment of worldwide lactase distributions found Canada to have an LNP rate of 59% (confidence interval [CI] 44%–74%). This estimate is rather high compared with earlier reports that listed Canada as a country with a 10% LNP rate; the authors had also noted that biases were likely because their calculations were based largely on Aboriginal studies. We hereby present an alternate LNP prevalence estimate at the national, provincial and territorial level. Methods We applied the referenced LNP frequency distribution data to the 2016 population census to account for the current multi-ethnic distributions in Canada. Prevalence rates for Canada, the provinces and territories were calculated. Results The national LNP rate is estimated at 44% (CI 41%–47%) after accounting for the 254 ethnic groups, with the lowest rates found in the eastern provinces and the highest rates in the Northwest Territories (57%) and Nunavut (66%), respectively. Conclusion Despite the heterogeneous nature of the referenced data and the inference measures taken, evidently, the validity of our LNP estimate is anchored on the inclusion of multi-ethnic groups representing the current Canadian demographic. Article in Journal/Newspaper Northwest Territories Nunavut Oxford University Press Journal of the Canadian Association of Gastroenterology 3 3 103 110 |
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description |
Abstract Objectives The lactase persistence/nonpersistence (LP/LNP) phenotypes follow a geographic pattern that is rooted in the gene-culture coevolution observed throughout the history of human migrations. The immense size and relatively open immigration policy have drawn migrants of diverse ethnicities to Canada. Among the multicultural demographic, two-thirds of the population are derived from the British Isles and northwestern France. A recent assessment of worldwide lactase distributions found Canada to have an LNP rate of 59% (confidence interval [CI] 44%–74%). This estimate is rather high compared with earlier reports that listed Canada as a country with a 10% LNP rate; the authors had also noted that biases were likely because their calculations were based largely on Aboriginal studies. We hereby present an alternate LNP prevalence estimate at the national, provincial and territorial level. Methods We applied the referenced LNP frequency distribution data to the 2016 population census to account for the current multi-ethnic distributions in Canada. Prevalence rates for Canada, the provinces and territories were calculated. Results The national LNP rate is estimated at 44% (CI 41%–47%) after accounting for the 254 ethnic groups, with the lowest rates found in the eastern provinces and the highest rates in the Northwest Territories (57%) and Nunavut (66%), respectively. Conclusion Despite the heterogeneous nature of the referenced data and the inference measures taken, evidently, the validity of our LNP estimate is anchored on the inclusion of multi-ethnic groups representing the current Canadian demographic. |
format |
Article in Journal/Newspaper |
author |
Fung, Manyan Xue, Xiaoqing Szilagyi, Andrew |
spellingShingle |
Fung, Manyan Xue, Xiaoqing Szilagyi, Andrew Estimating Lactase Nonpersistence Distributions in the Multi-Ethnic Canadian Demographic: A Population-Based Study |
author_facet |
Fung, Manyan Xue, Xiaoqing Szilagyi, Andrew |
author_sort |
Fung, Manyan |
title |
Estimating Lactase Nonpersistence Distributions in the Multi-Ethnic Canadian Demographic: A Population-Based Study |
title_short |
Estimating Lactase Nonpersistence Distributions in the Multi-Ethnic Canadian Demographic: A Population-Based Study |
title_full |
Estimating Lactase Nonpersistence Distributions in the Multi-Ethnic Canadian Demographic: A Population-Based Study |
title_fullStr |
Estimating Lactase Nonpersistence Distributions in the Multi-Ethnic Canadian Demographic: A Population-Based Study |
title_full_unstemmed |
Estimating Lactase Nonpersistence Distributions in the Multi-Ethnic Canadian Demographic: A Population-Based Study |
title_sort |
estimating lactase nonpersistence distributions in the multi-ethnic canadian demographic: a population-based study |
publisher |
Oxford University Press (OUP) |
publishDate |
2018 |
url |
http://dx.doi.org/10.1093/jcag/gwy068 http://academic.oup.com/jcag/article-pdf/3/3/103/33182423/gwy068.pdf |
genre |
Northwest Territories Nunavut |
genre_facet |
Northwest Territories Nunavut |
op_source |
Journal of the Canadian Association of Gastroenterology volume 3, issue 3, page 103-110 ISSN 2515-2084 2515-2092 |
op_rights |
http://creativecommons.org/licenses/by-nc/4.0/ |
op_doi |
https://doi.org/10.1093/jcag/gwy068 |
container_title |
Journal of the Canadian Association of Gastroenterology |
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3 |
container_issue |
3 |
container_start_page |
103 |
op_container_end_page |
110 |
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1810467161477480448 |