Increasing Prevalence and Stable Incidence Rates of Inflammatory Bowel Disease Among First Nations: Population-Based Evidence From a Western Canadian Province
Abstract Background There is limited to no evidence of the prevalence and incidence rates of inflammatory bowel disease (IBD) among Indigenous peoples. In partnership with Indigenous patients and family advocates, we aimed to estimate the prevalence, incidence, and trends over time of IBD among Firs...
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2021
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Online Access: | http://dx.doi.org/10.1093/ibd/izab096 https://academic.oup.com/ibdjournal/article-pdf/28/4/514/53788131/izab096.pdf |
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croxfordunivpr:10.1093/ibd/izab096 2024-09-15T18:06:37+00:00 Increasing Prevalence and Stable Incidence Rates of Inflammatory Bowel Disease Among First Nations: Population-Based Evidence From a Western Canadian Province Peña-Sánchez, Juan Nicolás Osei, Jessica Amankwah Marques Santos, Jose Diego Jennings, Derek Andkhoie, Mustafa Brass, Colten Bukassa-Kazadi, Germain Lu, Xinya Johnson-Jennings, Michelle Porter, Linda Porter, Rob Quintin, Carol-Lynne Sanderson, Rhonda Teucher, Ulrich Fowler, Sharyle Saskatchewan Health Research Foundation Saskatchewan Centre for Patient-Oriented Research Sprout College of Medicine Research University of Saskatchewan 2021 http://dx.doi.org/10.1093/ibd/izab096 https://academic.oup.com/ibdjournal/article-pdf/28/4/514/53788131/izab096.pdf en eng Oxford University Press (OUP) https://creativecommons.org/licenses/by-nc/4.0/ Inflammatory Bowel Diseases volume 28, issue 4, page 514-522 ISSN 1078-0998 1536-4844 journal-article 2021 croxfordunivpr https://doi.org/10.1093/ibd/izab096 2024-08-27T04:16:11Z Abstract Background There is limited to no evidence of the prevalence and incidence rates of inflammatory bowel disease (IBD) among Indigenous peoples. In partnership with Indigenous patients and family advocates, we aimed to estimate the prevalence, incidence, and trends over time of IBD among First Nations (FNs) since 1999 in the Western Canadian province of Saskatchewan. Methods We conducted a retrospective population-based study linking provincial administrative health data from the 1999-2000 to 2016-2017 fiscal years. An IBD case definition requiring multiple health care contacts was used. The prevalence and incidence data were modeled using generalized linear models and a negative binomial distribution. Models considered the effect of age groups, sex, diagnosis type (ulcerative colitis [UC], Crohn disease [CD]), and fiscal years to estimate prevalence and incidence rates and trends over time. Results The prevalence of IBD among FNs increased from 64/100,000 (95% confidence interval [CI], 62-66) in 1999-2000 to 142/100,000 (95% CI, 140-144) people in 2016-2017, with an annual average increase of 4.2% (95% CI, 3.2%-5.2%). Similarly, the prevalence of UC and CD, respectively, increased by 3.4% (95% CI, 2.3%-4.6%) and 4.1% (95% CI, 3.3%-4.9%) per year. In contrast, the incidence rates of IBD, UC, and CD among FNs depicted stable trends over time; no statistically significant changes were observed in the annual change trend tests. The ratio of UC to CD was 1.71. Conclusions We provided population-based evidence of the increasing prevalence and stable incidence rates of IBD among FNs. Further studies are needed in other regions to continue understanding the patterns of IBD among Indigenous peoples. Article in Journal/Newspaper First Nations Oxford University Press Inflammatory Bowel Diseases |
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Open Polar |
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Oxford University Press |
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croxfordunivpr |
language |
English |
description |
Abstract Background There is limited to no evidence of the prevalence and incidence rates of inflammatory bowel disease (IBD) among Indigenous peoples. In partnership with Indigenous patients and family advocates, we aimed to estimate the prevalence, incidence, and trends over time of IBD among First Nations (FNs) since 1999 in the Western Canadian province of Saskatchewan. Methods We conducted a retrospective population-based study linking provincial administrative health data from the 1999-2000 to 2016-2017 fiscal years. An IBD case definition requiring multiple health care contacts was used. The prevalence and incidence data were modeled using generalized linear models and a negative binomial distribution. Models considered the effect of age groups, sex, diagnosis type (ulcerative colitis [UC], Crohn disease [CD]), and fiscal years to estimate prevalence and incidence rates and trends over time. Results The prevalence of IBD among FNs increased from 64/100,000 (95% confidence interval [CI], 62-66) in 1999-2000 to 142/100,000 (95% CI, 140-144) people in 2016-2017, with an annual average increase of 4.2% (95% CI, 3.2%-5.2%). Similarly, the prevalence of UC and CD, respectively, increased by 3.4% (95% CI, 2.3%-4.6%) and 4.1% (95% CI, 3.3%-4.9%) per year. In contrast, the incidence rates of IBD, UC, and CD among FNs depicted stable trends over time; no statistically significant changes were observed in the annual change trend tests. The ratio of UC to CD was 1.71. Conclusions We provided population-based evidence of the increasing prevalence and stable incidence rates of IBD among FNs. Further studies are needed in other regions to continue understanding the patterns of IBD among Indigenous peoples. |
author2 |
Saskatchewan Health Research Foundation Saskatchewan Centre for Patient-Oriented Research Sprout College of Medicine Research University of Saskatchewan |
format |
Article in Journal/Newspaper |
author |
Peña-Sánchez, Juan Nicolás Osei, Jessica Amankwah Marques Santos, Jose Diego Jennings, Derek Andkhoie, Mustafa Brass, Colten Bukassa-Kazadi, Germain Lu, Xinya Johnson-Jennings, Michelle Porter, Linda Porter, Rob Quintin, Carol-Lynne Sanderson, Rhonda Teucher, Ulrich Fowler, Sharyle |
spellingShingle |
Peña-Sánchez, Juan Nicolás Osei, Jessica Amankwah Marques Santos, Jose Diego Jennings, Derek Andkhoie, Mustafa Brass, Colten Bukassa-Kazadi, Germain Lu, Xinya Johnson-Jennings, Michelle Porter, Linda Porter, Rob Quintin, Carol-Lynne Sanderson, Rhonda Teucher, Ulrich Fowler, Sharyle Increasing Prevalence and Stable Incidence Rates of Inflammatory Bowel Disease Among First Nations: Population-Based Evidence From a Western Canadian Province |
author_facet |
Peña-Sánchez, Juan Nicolás Osei, Jessica Amankwah Marques Santos, Jose Diego Jennings, Derek Andkhoie, Mustafa Brass, Colten Bukassa-Kazadi, Germain Lu, Xinya Johnson-Jennings, Michelle Porter, Linda Porter, Rob Quintin, Carol-Lynne Sanderson, Rhonda Teucher, Ulrich Fowler, Sharyle |
author_sort |
Peña-Sánchez, Juan Nicolás |
title |
Increasing Prevalence and Stable Incidence Rates of Inflammatory Bowel Disease Among First Nations: Population-Based Evidence From a Western Canadian Province |
title_short |
Increasing Prevalence and Stable Incidence Rates of Inflammatory Bowel Disease Among First Nations: Population-Based Evidence From a Western Canadian Province |
title_full |
Increasing Prevalence and Stable Incidence Rates of Inflammatory Bowel Disease Among First Nations: Population-Based Evidence From a Western Canadian Province |
title_fullStr |
Increasing Prevalence and Stable Incidence Rates of Inflammatory Bowel Disease Among First Nations: Population-Based Evidence From a Western Canadian Province |
title_full_unstemmed |
Increasing Prevalence and Stable Incidence Rates of Inflammatory Bowel Disease Among First Nations: Population-Based Evidence From a Western Canadian Province |
title_sort |
increasing prevalence and stable incidence rates of inflammatory bowel disease among first nations: population-based evidence from a western canadian province |
publisher |
Oxford University Press (OUP) |
publishDate |
2021 |
url |
http://dx.doi.org/10.1093/ibd/izab096 https://academic.oup.com/ibdjournal/article-pdf/28/4/514/53788131/izab096.pdf |
genre |
First Nations |
genre_facet |
First Nations |
op_source |
Inflammatory Bowel Diseases volume 28, issue 4, page 514-522 ISSN 1078-0998 1536-4844 |
op_rights |
https://creativecommons.org/licenses/by-nc/4.0/ |
op_doi |
https://doi.org/10.1093/ibd/izab096 |
container_title |
Inflammatory Bowel Diseases |
_version_ |
1810444024650137600 |