A Method for Estimating the Intensity of Overdominant Selection From the Distribution of Allele Frequencies
Abstract A method is proposed for estimating the intensity of overdominant selection scaled by the effective population size, S = 2Ns, from allele frequencies. The method is based on the assumption that, with strong overdominant selection, allele frequencies are nearly at their deterministic equilib...
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Oxford University Press (OUP)
2000
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Online Access: | http://dx.doi.org/10.1093/genetics/156.4.2119 https://academic.oup.com/genetics/article-pdf/156/4/2119/42030842/genetics2119.pdf |
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croxfordunivpr:10.1093/genetics/156.4.2119 2024-09-15T18:15:05+00:00 A Method for Estimating the Intensity of Overdominant Selection From the Distribution of Allele Frequencies Slatkin, Montgomery Muirhead, Christina A 2000 http://dx.doi.org/10.1093/genetics/156.4.2119 https://academic.oup.com/genetics/article-pdf/156/4/2119/42030842/genetics2119.pdf en eng Oxford University Press (OUP) https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model Genetics volume 156, issue 4, page 2119-2126 ISSN 1943-2631 journal-article 2000 croxfordunivpr https://doi.org/10.1093/genetics/156.4.2119 2024-08-05T04:30:31Z Abstract A method is proposed for estimating the intensity of overdominant selection scaled by the effective population size, S = 2Ns, from allele frequencies. The method is based on the assumption that, with strong overdominant selection, allele frequencies are nearly at their deterministic equilibrium values and that, to a first approximation, deviations depend only on S. Simulations verify that reasonably accurate estimates of S can be obtained for realistic sample sizes. The method is applied to data from several loci in the major histocompatibility complex (Mhc) in numerous human populations. For alleles distinguished by both serological typing and the sequence of the peptide-binding region, our estimates of S are comparable to those obtained by analysis of DNA sequences in showing that selection is strongest on HLA-B and weaker on HLA-A, HLA-DRB1, and HLA-DQA1. The intensity of selection on HLA-B varied considerably among populations. Two populations, Native American and Inuit, showed an excess rather than a deficiency in homozygosity. Comparable estimates of S were obtained for alleles at Mhc class II loci distinguished by serological reactions (serotyping) and by differences in the amino acid sequences of the peptide-binding region (molecular typing). A comparison of two types of data for DQA1 and DRB1 showed that serotyping led to generally lower estimates of S. Article in Journal/Newspaper inuit Oxford University Press Genetics 156 4 2119 2126 |
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Oxford University Press |
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English |
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Abstract A method is proposed for estimating the intensity of overdominant selection scaled by the effective population size, S = 2Ns, from allele frequencies. The method is based on the assumption that, with strong overdominant selection, allele frequencies are nearly at their deterministic equilibrium values and that, to a first approximation, deviations depend only on S. Simulations verify that reasonably accurate estimates of S can be obtained for realistic sample sizes. The method is applied to data from several loci in the major histocompatibility complex (Mhc) in numerous human populations. For alleles distinguished by both serological typing and the sequence of the peptide-binding region, our estimates of S are comparable to those obtained by analysis of DNA sequences in showing that selection is strongest on HLA-B and weaker on HLA-A, HLA-DRB1, and HLA-DQA1. The intensity of selection on HLA-B varied considerably among populations. Two populations, Native American and Inuit, showed an excess rather than a deficiency in homozygosity. Comparable estimates of S were obtained for alleles at Mhc class II loci distinguished by serological reactions (serotyping) and by differences in the amino acid sequences of the peptide-binding region (molecular typing). A comparison of two types of data for DQA1 and DRB1 showed that serotyping led to generally lower estimates of S. |
format |
Article in Journal/Newspaper |
author |
Slatkin, Montgomery Muirhead, Christina A |
spellingShingle |
Slatkin, Montgomery Muirhead, Christina A A Method for Estimating the Intensity of Overdominant Selection From the Distribution of Allele Frequencies |
author_facet |
Slatkin, Montgomery Muirhead, Christina A |
author_sort |
Slatkin, Montgomery |
title |
A Method for Estimating the Intensity of Overdominant Selection From the Distribution of Allele Frequencies |
title_short |
A Method for Estimating the Intensity of Overdominant Selection From the Distribution of Allele Frequencies |
title_full |
A Method for Estimating the Intensity of Overdominant Selection From the Distribution of Allele Frequencies |
title_fullStr |
A Method for Estimating the Intensity of Overdominant Selection From the Distribution of Allele Frequencies |
title_full_unstemmed |
A Method for Estimating the Intensity of Overdominant Selection From the Distribution of Allele Frequencies |
title_sort |
method for estimating the intensity of overdominant selection from the distribution of allele frequencies |
publisher |
Oxford University Press (OUP) |
publishDate |
2000 |
url |
http://dx.doi.org/10.1093/genetics/156.4.2119 https://academic.oup.com/genetics/article-pdf/156/4/2119/42030842/genetics2119.pdf |
genre |
inuit |
genre_facet |
inuit |
op_source |
Genetics volume 156, issue 4, page 2119-2126 ISSN 1943-2631 |
op_rights |
https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model |
op_doi |
https://doi.org/10.1093/genetics/156.4.2119 |
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Genetics |
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156 |
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4 |
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2119 |
op_container_end_page |
2126 |
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1810452819133595648 |