Mutations in New Cell Cycle Genes That Fail to Complement a Multiply Mutant Third Chromosome of Drosophila
Abstract We have simultaneously screened for new alleles and second site mutations that fail to complement five cell cycle mutations of Drosophila carried on a single third chromosome (gnu, polo, mgr, asp, stg). Females that are either transheterozygous for scott of the antartic (scant) and polo, or...
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Oxford University Press (OUP)
1996
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Online Access: | http://dx.doi.org/10.1093/genetics/144.3.1097 http://academic.oup.com/genetics/article-pdf/144/3/1097/39383495/genetics1097.pdf |
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croxfordunivpr:10.1093/genetics/144.3.1097 2024-09-15T17:49:15+00:00 Mutations in New Cell Cycle Genes That Fail to Complement a Multiply Mutant Third Chromosome of Drosophila White-Cooper, Helen Cannena, Mar Gonzalez, Cayetano Glover, David M 1996 http://dx.doi.org/10.1093/genetics/144.3.1097 http://academic.oup.com/genetics/article-pdf/144/3/1097/39383495/genetics1097.pdf en eng Oxford University Press (OUP) https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model Genetics volume 144, issue 3, page 1097-1111 ISSN 1943-2631 journal-article 1996 croxfordunivpr https://doi.org/10.1093/genetics/144.3.1097 2024-06-24T04:26:25Z Abstract We have simultaneously screened for new alleles and second site mutations that fail to complement five cell cycle mutations of Drosophila carried on a single third chromosome (gnu, polo, mgr, asp, stg). Females that are either transheterozygous for scott of the antartic (scant) and polo, or homozygous for scant produce embryos that show mitotic defects. A maternal effect upon embryonic mitoses is also seen in embryos derived from females transheterozygous with helter skelter (hsk) and either mgr or asp. deopatra (cleo), fails to complement asp but is not uncovered by a deficiency for asp. The mitotic phenotype of larvae heterozygous for cleo and the multiple mutant chromosome is similar to weak alleles of asp, but there are no defects in male meiosis. Mutations that failed to complement stgfell into two complementation groups corresponding to stg and a new gene noose. Three of the new stg alleles are early zygotic lethals, whereas the fourth is a pharate adult lethal allele that affects both mitosis and meiosis. Mutations in noose fully complement a small deficiency that removes stg, but when placed in trans to certain stg alleles, result in late lethality and mitotic abnormalities in larval brains. Article in Journal/Newspaper antartic* Oxford University Press Genetics 144 3 1097 1111 |
institution |
Open Polar |
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Oxford University Press |
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croxfordunivpr |
language |
English |
description |
Abstract We have simultaneously screened for new alleles and second site mutations that fail to complement five cell cycle mutations of Drosophila carried on a single third chromosome (gnu, polo, mgr, asp, stg). Females that are either transheterozygous for scott of the antartic (scant) and polo, or homozygous for scant produce embryos that show mitotic defects. A maternal effect upon embryonic mitoses is also seen in embryos derived from females transheterozygous with helter skelter (hsk) and either mgr or asp. deopatra (cleo), fails to complement asp but is not uncovered by a deficiency for asp. The mitotic phenotype of larvae heterozygous for cleo and the multiple mutant chromosome is similar to weak alleles of asp, but there are no defects in male meiosis. Mutations that failed to complement stgfell into two complementation groups corresponding to stg and a new gene noose. Three of the new stg alleles are early zygotic lethals, whereas the fourth is a pharate adult lethal allele that affects both mitosis and meiosis. Mutations in noose fully complement a small deficiency that removes stg, but when placed in trans to certain stg alleles, result in late lethality and mitotic abnormalities in larval brains. |
format |
Article in Journal/Newspaper |
author |
White-Cooper, Helen Cannena, Mar Gonzalez, Cayetano Glover, David M |
spellingShingle |
White-Cooper, Helen Cannena, Mar Gonzalez, Cayetano Glover, David M Mutations in New Cell Cycle Genes That Fail to Complement a Multiply Mutant Third Chromosome of Drosophila |
author_facet |
White-Cooper, Helen Cannena, Mar Gonzalez, Cayetano Glover, David M |
author_sort |
White-Cooper, Helen |
title |
Mutations in New Cell Cycle Genes That Fail to Complement a Multiply Mutant Third Chromosome of Drosophila |
title_short |
Mutations in New Cell Cycle Genes That Fail to Complement a Multiply Mutant Third Chromosome of Drosophila |
title_full |
Mutations in New Cell Cycle Genes That Fail to Complement a Multiply Mutant Third Chromosome of Drosophila |
title_fullStr |
Mutations in New Cell Cycle Genes That Fail to Complement a Multiply Mutant Third Chromosome of Drosophila |
title_full_unstemmed |
Mutations in New Cell Cycle Genes That Fail to Complement a Multiply Mutant Third Chromosome of Drosophila |
title_sort |
mutations in new cell cycle genes that fail to complement a multiply mutant third chromosome of drosophila |
publisher |
Oxford University Press (OUP) |
publishDate |
1996 |
url |
http://dx.doi.org/10.1093/genetics/144.3.1097 http://academic.oup.com/genetics/article-pdf/144/3/1097/39383495/genetics1097.pdf |
genre |
antartic* |
genre_facet |
antartic* |
op_source |
Genetics volume 144, issue 3, page 1097-1111 ISSN 1943-2631 |
op_rights |
https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model |
op_doi |
https://doi.org/10.1093/genetics/144.3.1097 |
container_title |
Genetics |
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144 |
container_issue |
3 |
container_start_page |
1097 |
op_container_end_page |
1111 |
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1810291020905054208 |